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--- home:diseases:diabetes2 [02.19.2019] – [Antimicrobial therapy in insulin resistance/type 2 diabetes] sallieq
+++ home:diseases:diabetes2 [02.19.2019] – [Antimicrobial therapy in insulin resistance/type 2 diabetes] sallieq
@@ Line 97: / Line 97: @@
-[[http://www.eurekalert.org/pub_releases/2010-08/uow-dcc082210.php|Diabetes can cause a sugar coating that smothers body's immune defences]]
+Diabetes can cause a sugar coating that smothers body's immune defences (({{pubmed>long:20674073}}))
 The researchers looked at the similarities in chemical structure between glucose in blood and body fluids, and two other sugar called mannose and fucose. These sugars are found on the surfaces of bacteria and fungi and act as targets for receptors in our body that have evolved to detect and bind to microbial sugars to then combat the infection.
-The research found that high levels of glucose outcompetes the binding of mannose and fucose to the specialized immune receptors, potentially blocking these receptors from detecting infectious bacteria and fungi. Glucose also binds in such a way that it inhibits the chemical processes that would normally then follow to combat infections. If this happens it can inhibit a range of key processes including:
+The research found that high levels of glucose outcompetes the binding of mannose and fucose to the specialized immune receptors, potentially blocking these receptors from detecting infectious bacteria and fungi. Glucose also binds in such a way that it inhibits the chemical processes that would normally then follow to combat infections.
-•	It can inhibit the function of immune system receptors called C-type lectins such as MBL (Mannose-binding lectin) which are known to bind to a sugar known as mannose that is present in the structure of infectious fungal bacterial cell walls. Unlike glucose, mannose does not exist in mammals as a free sugar in the blood.
-•	The loss of MBL function may also predispose the body to chronic inflammatory diseases, since MBL is involved in the processing and clearance of apoptotic cells (dying cells).
+<blockquote>Our findings offer a new perspective on how high glucose can potentially affect immunity and thus exert a negative impact on health. It also helps to emphasize the importance of good diet on preventing or controlling diseases such as diabetes. We will build on these ideas in order to consolidate the disease model and to investigate new routes to treatment and prevention.</blockquote>
-•	A number of C-type lectins tat can be affected by raised glucose levels, including MBL, but also including immune cell surface receptors DC-SIGN and DC-SIGNR, are found in key parts of our circulation and vascular system such as plasma, monocytes, platelets and endothelial cells that line blood vessels. Inhibiting the function of these key molecules in those settings could contribute to diabetic cardiovascular and renal complications.
-Warwick Medical School researcher Dr Daniel Mitchell said:
-"Our findings offer a new perspective on how high glucose can potentially affect immunity and thus exert a negative impact on health. It also helps to emphasize the importance of good diet on preventing or controlling diseases such as diabetes. We will build on these ideas in order to consolidate the disease model and to investigate new routes to treatment and prevention."
+Rubella virus-induced diabetes in the hamster.  (({{pubmed>long:3530856}}))
+<blockquote>The congenital rubella syndrome provides the best documentation in humans that a viral infection is associated with the subsequent development of insulin-dependent diabetes mellitus.</blockquote>
-. Rayfield EJ, Kelly KJ, Yoon JW. Rubella virus-in-
-duced diabetes in the hamster. Diabetes.
-;35:1278-1281.
-. Menser MA, Forrest JM, Bransby RD. Rubella in-
-fection and diabetes mellitus. Lancet. 1978;1:57-60.
-. Ramsingh AI, Chapman N, Tracy S.
-Coxsackieviruses and diabetes. Bioessays.
-;19:793-800.
 [[http://tinyurl.com/yrjqa3|Burden of Infection and Insulin Resistance in Healthy Middle-Aged Men]]

home/diseases/diabetes2.txt · Last modified: 09.14.2022 by 127.0.0.1