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home:diseases:diabetes2 [02.19.2019] – [Patients experiences] sallieq | home:diseases:diabetes2 [09.14.2022] (current) – external edit 127.0.0.1 | ||
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Major long term symptoms and effects of diabetes include retinopathy, | Major long term symptoms and effects of diabetes include retinopathy, | ||
- | ===== Recent | + | ===== Research ===== |
- | Prevention of microalbuminuria in patients with type 2 diabetes and hypertension. | + | Prevention of microalbuminuria in patients with type 2 diabetes and hypertension. |
- | Prevention of electrocardiographic left ventricular remodeling by the angiotensin receptor blocker olmesartan in patients with type 2 diabetes. | + | Prevention of electrocardiographic left ventricular remodeling by the angiotensin receptor blocker olmesartan in patients with type 2 diabetes. |
- | Adenosine is an endogenous metabolite that is released from all tissues and cells including liver, pancreas, muscle and fat, particularly under stress, intense exercise, or during cell damage. | + | Adenosine is an endogenous metabolite that is released from all tissues and cells including liver, pancreas, muscle and fat, particularly under stress, intense exercise, or during cell damage. |
- | The effects of diabetes on Adenosine A2BR receptor transcription and signaling | + | The effects of diabetes on Adenosine A2BR receptor transcription and signaling |
- | Results indicate a relationship between muscular TLR4, p-AMPK and NF-κB content and insulin sensitivity. The study also highlights that in situations of insulin resistance, such as in diabetic subjects, metformin treatment may prevent attenuation of activation of the inflammatory pathway. | + | Results indicate a relationship between muscular TLR4, p-AMPK and NF-κB content and insulin sensitivity. The study also highlights that in situations of insulin resistance, such as in diabetic subjects, metformin treatment may prevent attenuation of activation of the inflammatory pathway. |
- | Here, we investigated the hypothesis that the activation of the low-affinity adenosine receptor, the A2B receptor (A(2B)R), promotes glucose uptake in neurons and astrocytes, thereby linking brain activity with energy metabolism. | + | Here, we investigated the hypothesis that the activation of the low-affinity adenosine receptor, the A2B receptor (A(2B)R), promotes glucose uptake in neurons and astrocytes, thereby linking brain activity with energy metabolism. |
- | Our results illustrate that macrophage A2bAR signaling is needed and sufficient for relaying the protective effect of the A2bAR against HFD-induced tissue inflammation and insulin resistance in mice. (({{pubmed> | + | Our results illustrate that macrophage A2bAR signaling is needed and sufficient for relaying the protective effect of the A2bAR against HFD-induced tissue inflammation and insulin resistance in mice. (({{pmid> |
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+ | This trial aims to determine the effects of resistant starch (RS) subtype 2 (RS2) on glycemic status, metabolic endotoxemia and markers of oxidative stress. | ||
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+ | Among persons at high risk for type 2 diabetes not selected for vitamin D insufficiency, | ||
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- | Diet and exercise are the traditional lifestyle interventions used to prevent and treat type 2 diabetes. Different components of the diet can affect the course of type 2 diabetes, but a low carbohydrate diet appears to be giving the most significant results. (({{pubmed> | + | Diet and exercise are the traditional lifestyle interventions used to prevent and treat type 2 diabetes. Different components of the diet can affect the course of type 2 diabetes, but a low carbohydrate diet appears to be giving the most significant results. (({{pmid> |
- | Both endurance and resistance exercise yield improvements in many aspects of the metabolic derangements in diabetes type II.(({{pubmed> | + | Both endurance and resistance exercise yield improvements in many aspects of the metabolic derangements in diabetes type II.(({{pmid> |
Sulfonylureas, | Sulfonylureas, | ||
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===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
- | Rubella virus-induced diabetes in the hamster. | + | Rubella virus-induced diabetes in the hamster. |
< | < | ||
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The presence of bacterial components in blood predicts the onset of diabetes mellitus in a large general population recounts lead author Jacques Amar from the Centre Hospitalier Universitaire in Toulouse, France. The investigators determined the concentration of 16S rDNA in blood at baseline and assessed its relationship with incident diabetes mellitus and obesity over a follow-up period of 9 years. | The presence of bacterial components in blood predicts the onset of diabetes mellitus in a large general population recounts lead author Jacques Amar from the Centre Hospitalier Universitaire in Toulouse, France. The investigators determined the concentration of 16S rDNA in blood at baseline and assessed its relationship with incident diabetes mellitus and obesity over a follow-up period of 9 years. | ||
- | Linda Koch - comment in [[http:// | + | Linda Koch - comment in [[https:// |
</ | </ | ||
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CONCLUSIONS/ | CONCLUSIONS/ | ||
- | 16S rDNA was shown to be an independent marker of the risk of diabetes. These findings are evidence for the concept that tissue bacteria are involved in the onset of diabetes in humans.(({{pubmed> | + | 16S rDNA was shown to be an independent marker of the risk of diabetes. These findings are evidence for the concept that tissue bacteria are involved in the onset of diabetes in humans.(({{pmid> |
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To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below). | To what extent microbes contribute to the global diabetes burden, and to what extent antimicrobial therapy can prevent or reverse the disease, has to a limited degree been investigated in clinical trials (see below). | ||
- | However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pubmed> | + | However, the finding that obese and diabetic patients have higher levels of lipopolysaccharides (LPS, a bacterial product) in their bodies and that insulin level is correlated with the amount of LPS make a strong argument for infectious cause.(({{pmid> |
- | Inflammation (which is intimately associated with infection) induced by cytokines (({{pubmed> | + | Inflammation (which is intimately associated with infection) induced by cytokines (({{pmid> |
- | Abrogation of inflammation ameliorates insulin resistance. (({{pubmed> | + | Abrogation of inflammation ameliorates insulin resistance. (({{pmid> |
- | Deletion of the insulin receptor in myeloid cell lines inhibits development of insulin resistance.(({{pubmed> | + | Deletion of the insulin receptor in myeloid cell lines inhibits development of insulin resistance.(({{pmid> |
- | Further, beta amyloid, which has been identified as an antimicrobial peptide, | + | Further, beta amyloid, which has been identified as an antimicrobial peptide, |
< | < | ||
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- | Helicobacter pylori eradication led to a reduction in insulin resistance(({{pubmed> | + | Helicobacter pylori eradication led to a reduction in insulin resistance(({{pmid> |
- | The use of oxytetracycline in obese mice reduced insulin resistance(({{pubmed> | + | The use of oxytetracycline in obese mice reduced insulin resistance(({{pmid> |
- | Diabetes can cause a sugar coating that smothers body's immune defences (({{pubmed> | + | Diabetes can cause a sugar coating that smothers body's immune defences (({{pmid> |
The researchers looked at the similarities in chemical structure between glucose in blood and body fluids, and two other sugar called mannose and fucose. These sugars are found on the surfaces of bacteria and fungi and act as targets for receptors in our body that have evolved to detect and bind to microbial sugars to then combat the infection. | The researchers looked at the similarities in chemical structure between glucose in blood and body fluids, and two other sugar called mannose and fucose. These sugars are found on the surfaces of bacteria and fungi and act as targets for receptors in our body that have evolved to detect and bind to microbial sugars to then combat the infection. | ||
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- | [[http:// | + | [[https:// |
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diabetes, sarcoidosis, | diabetes, sarcoidosis, | ||
- | Read the [[http:// | + | Read the [[https:// |
< | < | ||
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+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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s177, s178: | s177, s178: | ||
Read first: | Read first: | ||
- | (({{pubmed> | + | (({{pmid> |
- | http:// | + | https:// |
- | egg consumption and diabetes(({{pubmed> | + | egg consumption and diabetes(({{pmid> |
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- | 10 Kramer, Hilary. “Diabetes is Killing our Economy”. Forbes.com. 13 Jan 2010. <http:// | + | 10 Kramer, Hilary. “Diabetes is Killing our Economy”. Forbes.com. 13 Jan 2010. <https:// |
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It is well documented, over several decades, that the BCG vaccine causes Sarcoidosis, | It is well documented, over several decades, that the BCG vaccine causes Sarcoidosis, | ||
" | " | ||
- | http:// | + | https:// |
" | " | ||
- | http:// | + | https:// |
" | " | ||
- | http:// | + | https:// |
The use of BCG vaccine has been banned in several countries , as being unsafe. Its use in Diabetes is not even a new idea, having been first mooted in 1991 | The use of BCG vaccine has been banned in several countries , as being unsafe. Its use in Diabetes is not even a new idea, having been first mooted in 1991 | ||
- | http:// | + | https:// |
Anybody who is researching the use of live vaccines, and who doesn' | Anybody who is researching the use of live vaccines, and who doesn' | ||
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The renin-angiotensin-aldosterone system and the eye in diabetes. | The renin-angiotensin-aldosterone system and the eye in diabetes. | ||
- | http:// | + | https:// |
Immuno-localization of the calcitriol receptor, calbindin-D28k and the plasma membrane calcium pump in the human eye. | Immuno-localization of the calcitriol receptor, calbindin-D28k and the plasma membrane calcium pump in the human eye. | ||
- | http:// | + | https:// |
Retinopathy | Retinopathy | ||
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Retinopathy, | Retinopathy, | ||
- | A similar process, macular degeneration, | + | A similar process, macular degeneration, |
- | Reduction of retinopathy during the course of the MP (in others) would tend to indicate it is also an inflammatory process. However, several of my Diabetes-research colleagues were convinced it was caused by the body failing to assimilate exogenous insulin correctly. see diagram summarizing some of the key relationships between the body's hormones and 1,25-D. You can access it at http:// | + | Reduction of retinopathy during the course of the MP (in others) would tend to indicate it is also an inflammatory process. However, several of my Diabetes-research colleagues were convinced it was caused by the body failing to assimilate exogenous insulin correctly. see diagram summarizing some of the key relationships between the body's hormones and 1,25-D. You can access it at https:// |
Be careful of the lasers. Th1 tissues don't heal as easily, and certainly not when a lot of incident radiation has been focused on them (excess Vit D production). | Be careful of the lasers. Th1 tissues don't heal as easily, and certainly not when a lot of incident radiation has been focused on them (excess Vit D production). | ||
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Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes | Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes | ||
- | http:// | + | https:// |
2nd lot of notes & COMMENTS | 2nd lot of notes & COMMENTS | ||
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* Legacy content | * Legacy content | ||
- | http:// | + | https:// |
- | < | + | < |
//**Liping Zhao**//</ | //**Liping Zhao**//</ | ||
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< | < | ||
- | Metabolic endotoxemia initiates obesity and insulin resistance.(({{pubmed> | + | Metabolic endotoxemia initiates obesity and insulin resistance.(({{pmid> |
Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. | Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. | ||
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From: Sue Lyons | From: Sue Lyons | ||
Date: 2011-03-24 20:44:55 | Date: 2011-03-24 20:44:55 | ||
- | Reply: | + | Reply: |
Janet, your suggestions to watch my blood sugar closely was timely as the day you wrote to me, I had a very low blood sugar episode while exercising! | Janet, your suggestions to watch my blood sugar closely was timely as the day you wrote to me, I had a very low blood sugar episode while exercising! | ||
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</ | </ | ||
< | < | ||
- | http:// | + | https:// |
Angiotensin II type 1 (AT(1)) receptor antagonists (angiotensin receptor blockers [ARBs]) are widely used for the treatment of not only hypertension but also cardiac dysfunction. B-type natriuretic peptide (BNP) is secreted mainly by the cardiac ventricle and plays an important role in the regulation of blood pressure (BP) and body fluid. It has been established that the plasma level of BNP is increased in patients with chronic heart failure in proportion to the severity of cardiac dysfunction. Because cardiac dysfunction is closely associated with a high risk of mortality in patients with diabetes mellitus, early identification and prevention of cardiac dysfunction are important. The objective of this study was to determine the effects of olmesartan medoxomil, a novel ARB, on the plasma level of BNP in hypertensive patients with type 2 diabetes. Methods: This was a preliminary, | Angiotensin II type 1 (AT(1)) receptor antagonists (angiotensin receptor blockers [ARBs]) are widely used for the treatment of not only hypertension but also cardiac dysfunction. B-type natriuretic peptide (BNP) is secreted mainly by the cardiac ventricle and plays an important role in the regulation of blood pressure (BP) and body fluid. It has been established that the plasma level of BNP is increased in patients with chronic heart failure in proportion to the severity of cardiac dysfunction. Because cardiac dysfunction is closely associated with a high risk of mortality in patients with diabetes mellitus, early identification and prevention of cardiac dysfunction are important. The objective of this study was to determine the effects of olmesartan medoxomil, a novel ARB, on the plasma level of BNP in hypertensive patients with type 2 diabetes. Methods: This was a preliminary, | ||
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1. Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008; | 1. Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008; | ||
- | //**H.H. Weng**// | + | //**H.H. Weng**// |
</ | </ | ||
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find more about Barney' | find more about Barney' | ||
- | - http:// | + | - https:// |
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- | Glucose test is [[http:// | + | Glucose test is [[https:// |
Blood glucose meters | Blood glucose meters | ||
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</ | </ | ||
- | ===== References ===== | + | ===== References =====</ |