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home:diseases:eyes [05.16.2019] – [Recent research] sallieq | home:diseases:eyes [09.14.2022] (current) – external edit 127.0.0.1 | ||
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When researchers at the Keio University School of Medicine used a bacterial endotoxin to create a condition similar to uveitis in mice, they found that the eye inflammation of the animals decreased significantly after they were administered [[home: | When researchers at the Keio University School of Medicine used a bacterial endotoxin to create a condition similar to uveitis in mice, they found that the eye inflammation of the animals decreased significantly after they were administered [[home: | ||
- | (a dangerously different ARB).(({{pubmed> | + | (a dangerously different ARB).(({{pmid> |
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=====Evidence of infectious cause===== | =====Evidence of infectious cause===== | ||
- | Cell wall deficient bacteria have been detected on multiple occasions in the eye. Researchers at Columbia under Emil Wirostko detected non-cultivable cell wall-deficient bacterial pathogens in patients with chronic ocular inflammatory disease. In one experiment, they injected these organisms into mouse eyelids, which subsequently caused the mice to develop inflammatory eye disease. They also found that these cell wall deficient pathogens could disseminate and cause similar inflammation in the heart, gut and lungs.(({{pubmed> | + | Cell wall deficient bacteria have been detected on multiple occasions in the eye. Researchers at Columbia under Emil Wirostko detected non-cultivable cell wall-deficient bacterial pathogens in patients with chronic ocular inflammatory disease. In one experiment, they injected these organisms into mouse eyelids, which subsequently caused the mice to develop inflammatory eye disease. They also found that these cell wall deficient pathogens could disseminate and cause similar inflammation in the heart, gut and lungs.(({{pmid> |
- | Additionally, | + | Additionally, |
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==== Age-related macular degeneration ==== | ==== Age-related macular degeneration ==== | ||
- | Similarly, researchers at the Massachusetts Eye and Ear Infirmary found //Chlamydia pneumoniae// | + | Similarly, researchers at the Massachusetts Eye and Ear Infirmary found //Chlamydia pneumoniae// |
- | AMD can result in loss of central vision, which entails the inability to see fine details, to read, or to recognize faces. According to the American Academy of Ophthalmology, | + | AMD can result in loss of central vision, which entails the inability to see fine details, to read, or to recognize faces. According to the American Academy of Ophthalmology, |
=== Recent research into AMD === | === Recent research into AMD === | ||
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CONCLUSIONS: | CONCLUSIONS: | ||
- | High adherence to a Mediterranean diet and regular physical activity seem to be protective factors for AMD in a Portuguese population. The effect of the diet is likely driven by the increased consumption of vegetables, fruits, and nuts. (({{pubmed> | + | High adherence to a Mediterranean diet and regular physical activity seem to be protective factors for AMD in a Portuguese population. The effect of the diet is likely driven by the increased consumption of vegetables, fruits, and nuts. (({{pmid> |
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We also found probable evidence that higher intakes of meat increased the risk of cataracts and macular degeneration. Dietary calcium and iron appeared protective against glaucoma, but not in supplemental form. | We also found probable evidence that higher intakes of meat increased the risk of cataracts and macular degeneration. Dietary calcium and iron appeared protective against glaucoma, but not in supplemental form. | ||
- | We would caution intake of supplementary antioxidants for those with ocular disease. | + | We would caution intake of supplementary antioxidants for those with ocular disease. |
==== Diabetic macular edema ==== | ==== Diabetic macular edema ==== | ||
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CONCLUSIONS: | CONCLUSIONS: | ||
- | Higher homocysteine levels were associated with an increased CSMT, AMT, and AMV in diabetic patients without DME. This link may indicate that patients with type 2 diabetes with increased levels of plasma tHcy are more prone to develop a clinical manifestation of DME. (({{pubmed> | + | Higher homocysteine levels were associated with an increased CSMT, AMT, and AMV in diabetic patients without DME. This link may indicate that patients with type 2 diabetes with increased levels of plasma tHcy are more prone to develop a clinical manifestation of DME. (({{pmid> |
==== Cataracts ==== | ==== Cataracts ==== | ||
- | Similarly, Wirostko’s group noted that cataracts developed in the eyes of 14 of the 15 mice who had been exposed to the cell wall deficient forms, whereas no cataracts developed in the eyes of 200 control mice that had not come in contact with the pathogens. | + | Similarly, Wirostko’s group noted that cataracts developed in the eyes of 14 of the 15 mice who had been exposed to the cell wall deficient forms, whereas no cataracts developed in the eyes of 200 control mice that had not come in contact with the pathogens. |
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In a prospective, | In a prospective, | ||
- | < | + | < |
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Symptoms of uveitis include redness of the eye, blurred vision, photosensitivity (photophobia), | Symptoms of uveitis include redness of the eye, blurred vision, photosensitivity (photophobia), | ||
- | Some cases are widely accepted to be due to bacteria or viruses. Other cases are associated with " | + | Some cases are widely accepted to be due to bacteria or viruses. Other cases are associated with " |
- | In a 2008 prospective study of 1,321 patients with uveitis, a team of French researchers used polymerase chain reaction (PCR) to search for evidence of microbes. Researchers found a variety of fastidious and difficult-to-grow bacteria including spirochetes, | + | In a 2008 prospective study of 1,321 patients with uveitis, a team of French researchers used polymerase chain reaction (PCR) to search for evidence of microbes. Researchers found a variety of fastidious and difficult-to-grow bacteria including spirochetes, |
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//**Trevor Marshall, PhD**//</ | //**Trevor Marshall, PhD**//</ | ||
- | The Vitamin D Receptor is involved in the transcription of several key proteins that form the structure of the retina. According to researchers at McGill University, | + | The Vitamin D Receptor is involved in the transcription of several key proteins that form the structure of the retina. According to researchers at McGill University, |
* Epidermal retinal dehydrogenase | * Epidermal retinal dehydrogenase | ||
* Retinal outer segment membrane protein | * Retinal outer segment membrane protein | ||
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sarcoidosis (Hedfort Syndrome), uveitis | sarcoidosis (Hedfort Syndrome), uveitis | ||
- | Read the [[http:// | + | Read the [[https:// |
< | < | ||
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5 Cambridge Center 8th Floor | 5 Cambridge Center 8th Floor | ||
Cambridge, MA 02142 | Cambridge, MA 02142 | ||
- | http:// | + | https:// |
Phone 617-621-6377 | Phone 617-621-6377 | ||
Fax 617-494-1430 | Fax 617-494-1430 | ||
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Dr. Foster wrote a book on uveitis; he and his research group have published a huge number of articles on it. Because he is such a well-known specialist, he has seen more cases of uveitis than pretty much anyone else. | Dr. Foster wrote a book on uveitis; he and his research group have published a huge number of articles on it. Because he is such a well-known specialist, he has seen more cases of uveitis than pretty much anyone else. | ||
- | Here is a [[http:// | + | Here is a [[https:// |
- | You can also contact the [[http:// | + | You can also contact the [[https:// |
If you are faced with eye surgery or complicated-to-manage inflammatory eye conditions , it would be a good idea to get Dr. Foster' | If you are faced with eye surgery or complicated-to-manage inflammatory eye conditions , it would be a good idea to get Dr. Foster' | ||
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+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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Study Shows Bacterium Present in Eyes with " | Study Shows Bacterium Present in Eyes with " | ||
- | http:// | + | https:// |
ARB reduces Uveitis due to bacterial toxin | ARB reduces Uveitis due to bacterial toxin | ||
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There is an article in PubMed Central in which Wirostko explains how mollicutes, transfected from humans, infected first the eyes of mice, then their whole bodies. Somehow it has slipped my attention since I first saw it. You might be interested to take a look. The images are not as compelling as the the original publications from the 1980' | There is an article in PubMed Central in which Wirostko explains how mollicutes, transfected from humans, infected first the eyes of mice, then their whole bodies. Somehow it has slipped my attention since I first saw it. You might be interested to take a look. The images are not as compelling as the the original publications from the 1980' | ||
- | http:// | + | https:// |
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</ | </ | ||
- | ===== References ===== | + | ===== References =====</ |