This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revision Previous revision
home:diseases:eyes [05.16.2019]
sallieq [Types]
home:diseases:eyes [05.16.2019] (current)
sallieq [Recent research]
Line 21: Line 21:
 https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC5331551/​ https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC5331551/​
 +Getting the most out of spinach: Maximizing the antioxidant lutein
 +Eat your spinach in the form of a smoothie or juice -- this is the best way to obtain the antioxidant lutein, according to new research. High levels of lutein are found in dark green vegetables, and researchers at the university have compared different ways of preparing fresh spinach in order to maximize the levels of lutein in finished food.
 +Lutein and Brain Function
 +Lutein is one of the most prevalent carotenoids in nature and in the human diet. Together with zeaxanthin, it is highly concentrated as macular pigment in the foveal retina of primates, attenuating blue light exposure, providing protection from photo-oxidation and enhancing visual performance. Recently, interest in lutein has expanded beyond the retina to its possible contributions to brain development and function. Only primates accumulate lutein within the brain, but little is known about its distribution or physiological role. Our team has begun to utilize the rhesus macaque (Macaca mulatta) model to study the uptake and bio-localization of lutein in the brain. Our overall goal has been to assess the association of lutein localization with brain function. In this review, we will first cover the evolution of the non-human primate model for lutein and brain studies, discuss prior association studies of lutein with retina and brain function, and review approaches that can be used to localize brain lutein. We also describe our approach to the biosynthesis of 13C-lutein, which will allow investigation of lutein flux, localization,​ metabolism and pharmacokinetics. Lastly, we describe potential future research opportunities.
 +Inhibitory Effects of Lutein on Endotoxin-Induced Uveitis in Lewis Rats
 +Lutein deposits in the macula and lens of human eyes with high concentration and is well known as an eye-protective nutrient for its beneficial effects on eye disease such as age-related macular degeneration and cataract. The purpose of the present study was to investigate the effects of lutein on endotoxin-induced uveitis (EIU) in rats.
 +Lutein suppressed the development of EIU in a dose-dependent fashion. The anti-inflammatory effect of 100 mg/kg lutein was as strong as that of 1 mg/kg dexamethasone. Treatment with lutein reduced the concentrations of NO, TNF-α, IL-6, PGE2, MCP-1, and MIP-2 in aqueous humor. Lutein also suppressed the activation of NF-κB in the ICB as well as iNOS and COX-2 expression and IκB degradation in RAW cells.
 +Foods highest in Lutein+Zeaxanthin:​ (based on levels per 200-Calorie serving)
 +Individual lutein and zeaxanthin values of common foods:
 ===== Marshall Protocol for chronic eye diseases ===== ===== Marshall Protocol for chronic eye diseases =====
home/diseases/eyes.txt · Last modified: 05.16.2019 by sallieq
© 2015, Autoimmunity Research Foundation. All Rights Reserved.