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home:diseases:hiv_and_aids [02.19.2019] – [More research into CD38 and immune function] sallieq | home:diseases:hiv_and_aids [02.19.2019] – [Research on children] sallieq | ||
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===== Research on children ===== | ===== Research on children ===== | ||
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+ | An observational study of children vertically infected with human immunodeficiency virus type 1 (HIV-1) was performed to determine the role of CD38 expression in CD8+ T cells as prognostic marker of virological failure in children receiving HAART. | ||
- | CD38 Expression in CD8+ T Cells Predicts Virological Failure in HIV Type 1–Infected Children Receiving Antiretroviral Therapy | + | We studied 42 children who were receiving |
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- | Infection with HIV-1 induces lymphoid activation, resulting in an increase in T cell activation–associated antigens, such as CD38 [1–3]. Also, CD38 could represent HIV-1–specific or cytokine-activated cells [4–6]. | + | |
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- | It has also been shown that the initiation of antiretroviral therapy | + | |
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- | Children with AIDS had higher CD8+CD38+ MFI values than did children without AIDS (mean ± SEM, 15.83 ± 1.15 vs. 11.54 ± 0.92; P = .008). Also, the CD8+CD38+ percentage was higher in children with AIDS (mean ± SEM, 70.53% ± 2.88%) than in children without AIDS (mean ± SEM, 61.67% ± 3.47%; P = .054). | + | |
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- | In the present study, we confirmed that CD8+CD38+ T cell count is a marker of immune activation and that this expression | + | |
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- | The increase in the CD8+CD38+ T cell count has been associated with elevated VLs in HIV-1–infected children [2] and adults [28]. Tilling et al. [13] monitored | + | |
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- | However, increased CD38 expression in CD8+ T cells obtained from patients with Epstein-Barr virus infection and other infections has been reported [33, 34]. The CD8+CD38+ T cell count may represent a sensitive marker for the early prediction of occurrence of infectious diseases in HIV-1–infected | + | |
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- | In conclusion, in this study, we demonstrate—to our knowledge, for the first time—that CD8+CD38+ T cell count is a good long-term prognostic marker of therapeutic failure in HIV-1–infected | + | |
+ | Children with CD38 values in CD8+ T cells that were higher than the median had a higher incidence and relative risk of virological failure than did those with values lower than the median. In conclusion, we demonstrate for the first time that CD8+CD38+ T cell count is a good prognostic marker of therapeutic failure in HIV-1–infected children. | ||
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