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home:diseases:hiv_and_aids [04.26.2020] – [HIV and AIDS] sallieqhome:diseases:hiv_and_aids [09.14.2022] (current) – external edit 127.0.0.1
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 ====== HIV and AIDS ====== ====== HIV and AIDS ======
  
-[[https:home:pathogenesis:microbiota:interaction#viruses|Effects of bacteria and viruses on their human host]] </article>+<relatedarticle> [[https:home:pathogenesis:microbiota:interaction#viruses|Effects of bacteria and viruses on their human host]] </article>
  
  
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 <mainarticle> [[home:pathogenesis:vitamind:metabolism|Metabolism of vitamin D and the Vitamin D Receptor]] </article> <mainarticle> [[home:pathogenesis:vitamind:metabolism|Metabolism of vitamin D and the Vitamin D Receptor]] </article>
  
-HIV uses the VDR to recognize its own LTR promoter region in order to transcribe its own genome, thus taking over the VDR.(({{pubmed>long:17556530}}))+HIV uses the VDR to recognize its own LTR promoter region in order to transcribe its own genome, thus taking over the VDR.(({{pmid>long:17556530}}))
  
 {{section>:home:pathogenesis:vitamind:metabolism#hivaids&noheader&firstseconly}} {{section>:home:pathogenesis:vitamind:metabolism#hivaids&noheader&firstseconly}}
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 There is no evidence that supplemental vitamin D helps HIV or AIDS patients. There is no evidence that supplemental vitamin D helps HIV or AIDS patients.
  
-<blockquote>Vitamin D supplementation is associated with reduced immune activation levels in HIV-1-infected patients on suppressive antiretroviral therapy. (({{pubmed>long:25493593}})) +<blockquote>Vitamin D supplementation is associated with reduced immune activation levels in HIV-1-infected patients on suppressive antiretroviral therapy. (({{pmid>long:25493593}})) 
  
 Of note, we observed that patients with low vitamin D levels displayed a reduced CD4/CD8 ratio (P ¼ 0.03, Table 1), which is usually a sign of increased immune activation in HIV-infected patients receiving effective ART [16]. We also analyzed CD38 expression on the surface of memory CD8+ T cells as a robust marker of immune activation. Although there was substantial interindividual variability, patients with severe vitamin D deficiency displayed modest but statistically significant higher levels of CD38 expression, compared with individuals with normal vitamin D (P ¼ 0.04, Table 1). Of note, we observed that patients with low vitamin D levels displayed a reduced CD4/CD8 ratio (P ¼ 0.03, Table 1), which is usually a sign of increased immune activation in HIV-infected patients receiving effective ART [16]. We also analyzed CD38 expression on the surface of memory CD8+ T cells as a robust marker of immune activation. Although there was substantial interindividual variability, patients with severe vitamin D deficiency displayed modest but statistically significant higher levels of CD38 expression, compared with individuals with normal vitamin D (P ¼ 0.04, Table 1).
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 Pathogens are able spread effectively in an immunocompromised environment. This means it's possible that AIDS patients pick up substantial pathogen loads. It is further possible that it is these Th1 pathogens, which kill patients. Viral co-infections (including Epstein-Barr virus, Human Herpes Virus 6, etc.) are found in all the diseases the Marshall Protocol treats, but the viruses are not believed to bethe proximate cause of disease.  Pathogens are able spread effectively in an immunocompromised environment. This means it's possible that AIDS patients pick up substantial pathogen loads. It is further possible that it is these Th1 pathogens, which kill patients. Viral co-infections (including Epstein-Barr virus, Human Herpes Virus 6, etc.) are found in all the diseases the Marshall Protocol treats, but the viruses are not believed to bethe proximate cause of disease. 
  
-Mycobacterium avium-intracellulare infection and immunoblastic sarcoma in a fatal case of AIDS.  (({{pubmed>long:    3732865}}))+Mycobacterium avium-intracellulare infection and immunoblastic sarcoma in a fatal case of AIDS.  (({{pmid>long:    3732865}}))
  
-[[http://www.joimr.org/JOIMR-2007-5-1-Cantwell.pdf|Do TB-type bacteria cause AIDS?]]+[[https://www.joimr.org/JOIMR-2007-5-1-Cantwell.pdf|Do TB-type bacteria cause AIDS?]]
  
 ===== CD38 ===== ===== CD38 =====
  
  
-CD38 plays a role in effective containment of mycobacteria within granulomata and polarization of Th1 immune responses against Mycobacterium avium. (({{pubmed>long:17533152}})) +CD38 plays a role in effective containment of mycobacteria within granulomata and polarization of Th1 immune responses against Mycobacterium avium. (({{pmid>long:17533152}})) 
  
 ... ...
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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 his HIV-positive patients, even if they are not deficient. his HIV-positive patients, even if they are not deficient.
  
-http://www.medpagetoday.com/tbprint.cfm?tbid=22132+https://www.medpagetoday.com/tbprint.cfm?tbid=22132
  
 Indeed, a third study here confirmed the risk of bone loss among those with HIV. Indeed, a third study here confirmed the risk of bone loss among those with HIV.
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   * Legacy content   * Legacy content
-    * http://www.marshallprotocol.com/forum37/9768.html#p39531 s329 +    * https://www.marshallprotocol.com/forum37/9768.html#p39531 s329 
-    * http://www.marshallprotocol.com/view_topic.php?id=4404&forum_id=28&jump_to=40327#p40327 s330 +    * https://www.marshallprotocol.com/view_topic.php?id=4404&forum_id=28&jump_to=40327#p40327 s330 
-    * http://www.marshallprotocol.com/view_topic.php?id=4404&forum_id=28&jump_to=40685#p40685 s331 +    * https://www.marshallprotocol.com/view_topic.php?id=4404&forum_id=28&jump_to=40685#p40685 s331 
-    * http://www.marshallprotocol.com/view_topic.php?id=4404&forum_id=28&jump_to=40688#p40688 s332 +    * https://www.marshallprotocol.com/view_topic.php?id=4404&forum_id=28&jump_to=40688#p40688 s332 
-    * http://www.marshallprotocol.com/forum37/9768.html#p72952 s333 +    * https://www.marshallprotocol.com/forum37/9768.html#p72952 s333 
-    * http://www.marshallprotocol.com/forum37/9768.html#p112657 s334+    * https://www.marshallprotocol.com/forum37/9768.html#p112657 s334
  
-http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=92475&Ausgabe=231692&ProduktNr=223834+https://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=92475&Ausgabe=231692&ProduktNr=223834 
 + 
 +===== References =====</nodisp>
  
-===== References ===== 
home/diseases/hiv_and_aids.txt · Last modified: 09.14.2022 by 127.0.0.1
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