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Hemophagocytic lymphohistiocytosis (HLH) or hemophagocytic syndrome has increased destruction of red and white blood cells as its major hallmark. Fever, splenomegaly, jaundice, lymphocytosis and histiocytosis are the most usual symptoms and findings in this syndrome.
HLH can be either primary or secondary. Secondary refers to the acquired form and is the form that will be described here.
Several findings link the syndrome to infections: