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--- home:diseases:hypercalcemia [02.18.2019] – [Hypercalcemia (hypercalcaemia)] sallieq
+++ home:diseases:hypercalcemia [02.18.2019] – [Hypercalcemia (hypercalcaemia)] sallieq
@@ Line 8: / Line 8: @@
 [[http://www.mayoclinic.org/diseases-conditions/hypercalcemia/basics/definition/con-20031513|Mayo Clinic overview]]
+===== Introduction =====
 Hypercalcaemia - presentation and management  (({{pubmed>long:28572230}}))
-<blockquote>Hypercalcaemia is a common disorder normally caused by primary hyperparathyroidism (PHPT) or malignancy. A proportion of cases present as an emergency, which carries a significant mortality. Emergency management of hypercalcaemia is based on intravenous rehydration with normal saline but when this is inadequate, bisphosphonate therapy is used; more recently the novel anti-resorbtive agent denosumab has been shown to have a useful role in treatment. It is estimated that up to 10% of all cases of PHPT presenting under the age of 45 years have an underlying genetic predisposition; nine potentially causative genes are now recognised and may be screened in routine clinical practice. Although parathyroidectomy is the only curative treatment for PHPT, this is indicated in a minority of cases.
+<blockquote>Hypercalcaemia is a common disorder normally caused by primary hyperparathyroidism (PHPT) or malignancy. A proportion of cases present as an emergency, which carries a significant mortality. Emergency management of hypercalcaemia is based on intravenous rehydration with normal saline but when this is inadequate, bisphosphonate therapy is used; more recently the novel anti-resorbtive agent denosumab has been shown to have a useful role in treatment.
+Although parathyroidectomy is the only curative treatment for PHPT, this is indicated in a minority of cases.
 </blockquote>

home/diseases/hypercalcemia.txt · Last modified: 09.14.2022 by 127.0.0.1