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home:diseases:hypercalcemia [05.24.2019]
sallieq [Introduction]
home:diseases:hypercalcemia [07.27.2019]
sallieq [Infants]
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 Cancer-Related Hypercalcemia. ​ (({{pubmed>​long:​27170690}})) Cancer-Related Hypercalcemia. ​ (({{pubmed>​long:​27170690}}))
 <​blockquote>​The most common causes include humoral hypercalcemia of malignancy mediated by parathyroid hormone-related peptide, osteolytic cytokine production, and excess 1,​25-dihydroxy vitamin D production.</​blockquote>​ <​blockquote>​The most common causes include humoral hypercalcemia of malignancy mediated by parathyroid hormone-related peptide, osteolytic cytokine production, and excess 1,​25-dihydroxy vitamin D production.</​blockquote>​
 +
 +The active form of vitamin D3 , calcitriol, is a potent antiproliferative compound. However, when effective antitumor doses of calcitriol are used, hypercalcemic effects are observed, thus blocking its therapeutic application. (({{pubmed>​long: ​   31025400}}))
  
 ==== Infants ==== ==== Infants ====
  
-Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. ​ (({{pubmed>​long:​000}}))+Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. ​ (({{pubmed>​long:​26681795}}))
  
 <​blockquote>​ CYP2R1 has been identified as the most important 25-hydroxylase,​ and a critical role for CYP24A1 in humans was noted in studies showing that inactivating mutations in CYP24A1 are a probable cause of idiopathic infantile hypercalcemia. <​blockquote>​ CYP2R1 has been identified as the most important 25-hydroxylase,​ and a critical role for CYP24A1 in humans was noted in studies showing that inactivating mutations in CYP24A1 are a probable cause of idiopathic infantile hypercalcemia.
home/diseases/hypercalcemia.txt · Last modified: 07.27.2019 by sallieq
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