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home:diseases:hypertension [01.04.2019] – [Inflammation and Hypertension] sallieqhome:diseases:hypertension [01.04.2019] – [Notes and comments] sallieq
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-In this review we summarize the recent evidence that highlights the involvement of low-grade inflammation in the development and pathophysiology of hypertension. +<blockquote>In this review we summarize the recent evidence that highlights the involvement of low-grade inflammation in the development and pathophysiology of hypertension. 
  
 RECENT FINDINGS: Essential hypertension is characterized by increased peripheral vascular resistance to blood flow, due in large part to vascular remodeling. Vascular changes in hypertension are associated with mechanical and humoral factors that modulate signaling events, resulting in abnormal function, media growth, extracellular matrix deposition and inflammation. Recent evidence suggests that inflammation is present in the vasculature in animal models of hypertension. Inflammatory markers, such as C-reactive protein, are associated with vascular lesions in humans, and are predictive of cardiovascular outcome. In animal and human studies, pro-inflammatory components of the renin-angiotensin-aldosterone system have been demonstrated in large conduit and small arteries in the kidney and heart. Peroxisome proliferator-activated receptor activators are drugs with metabolic properties that have been demonstrated to exert anti-inflammatory effects on the vasculature, and there is now evidence that these actions may be protective for blood vessels.  RECENT FINDINGS: Essential hypertension is characterized by increased peripheral vascular resistance to blood flow, due in large part to vascular remodeling. Vascular changes in hypertension are associated with mechanical and humoral factors that modulate signaling events, resulting in abnormal function, media growth, extracellular matrix deposition and inflammation. Recent evidence suggests that inflammation is present in the vasculature in animal models of hypertension. Inflammatory markers, such as C-reactive protein, are associated with vascular lesions in humans, and are predictive of cardiovascular outcome. In animal and human studies, pro-inflammatory components of the renin-angiotensin-aldosterone system have been demonstrated in large conduit and small arteries in the kidney and heart. Peroxisome proliferator-activated receptor activators are drugs with metabolic properties that have been demonstrated to exert anti-inflammatory effects on the vasculature, and there is now evidence that these actions may be protective for blood vessels. 
  
-SUMMARY: Inflammatory processes are important participants in the pathophysiology of hypertension and cardiovascular disease. The identification of the mechanisms leading to the activation of inflammation should contribute to the development of specific therapeutic approaches to apply in hypertension and its complications.     (({{pubmed>long:16481882}}))+SUMMARY: Inflammatory processes are important participants in the pathophysiology of hypertension and cardiovascular disease. The identification of the mechanisms leading to the activation of inflammation should contribute to the development of specific therapeutic approaches to apply in hypertension and its complications.     (({{pubmed>long:16481882}}))</blockquote>
  
 //see also// //see also//
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 Wilke, R. A., R. U. Simpson, et al. (2009). "Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension." Pharmacogenomics 10(11): 1789-1797.   (({{pubmed>long:19891555}})) Wilke, R. A., R. U. Simpson, et al. (2009). "Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension." Pharmacogenomics 10(11): 1789-1797.   (({{pubmed>long:19891555}}))
 +<blockquote>
  
 AIMS: We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension. MATERIALS & METHODS: Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Using the Marshfield Clinic Personalized Medicine Research Project, we genotyped 205 subjects with hypertension and congestive heart failure, 206 subjects with hypertension alone and 206 controls (frequency matched by age and gender).  AIMS: We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension. MATERIALS & METHODS: Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Using the Marshfield Clinic Personalized Medicine Research Project, we genotyped 205 subjects with hypertension and congestive heart failure, 206 subjects with hypertension alone and 206 controls (frequency matched by age and gender). 
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-For some, the absence of well-defined causal connections between diseases and surrogate outcomes is a tribute to how truly complicated chronic inflammatory diseases are. Ralph B D'Agostino characterizes hypertension in this way: “There is no reason to believe that hypertension is simply elevated blood pressure. Hypertension is much more complex.” (({{pubmed>long:11714414}}))+For some, the absence of well-defined causal connections between diseases and surrogate outcomes is a tribute to how truly complicated chronic inflammatory diseases are. Ralph B D'Agostino characterizes hypertension in this way: “There is no reason to believe that hypertension is simply elevated blood pressure. Hypertension is much more complex.” (({{pubmed>long:11714414}}))</blockquote>
  
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-[[http://hyper.ahajournals.org/content/hypertensionaha/early/2014/07/07/HYPERTENSIONAHA.114.03282.full.pdf|Dose-Dependent  Arterial  Destiffening  and  Inward   
-Remodeling  After  Olmesartan  in  Hypertensives  With   
-Metabolic  Syndrome]] 
  
 ===== Members' experiences ===== ===== Members' experiences =====
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 //BROKEN LINK// [[http://hyper.ahajournals.org/cgi/content/full/44/3/253|Is Vascular Endothelial Growth Factor a Missing Link Between Hypertension and Inflammation?]] //BROKEN LINK// [[http://hyper.ahajournals.org/cgi/content/full/44/3/253|Is Vascular Endothelial Growth Factor a Missing Link Between Hypertension and Inflammation?]]
  
-link to current research by 2 authoers [[http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Savoia%20C%22[Author]|Savoia C]], [[http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Schiffrin%20EL%22[Author]|Schiffrin EL.]]+ANOR //DEAD LINK//  
 +[[http://hyper.ahajournals.org/content/hypertensionaha/early/2014/07/07/HYPERTENSIONAHA.114.03282.full.pdf|Dose-Dependent  Arterial  Destiffening  and  Inward   
 +Remodeling  After  Olmesartan  in  Hypertensives  With   
 +Metabolic  Syndrome]] 
 + 
 +link to current research by 2 authers [[http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Savoia%20C%22[Author]|Savoia C]], [[http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Schiffrin%20EL%22[Author]|Schiffrin EL.]]
  
 Vitamins  Vitamins 
home/diseases/hypertension.txt · Last modified: 09.14.2022 by 127.0.0.1
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