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home:diseases:kidney_stones [05.02.2011] – external edit 127.0.0.1home:diseases:kidney_stones [07.08.2011] – [Role of elevated 1,25-D] paulalbert
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 Patients on the Marshall Protocol (MP) are somewhat less likely to get kidney stones, especially in later stages of the treatment, due to the restoration of proper vitamin D metabolism. Those patients who do develop kidney stones since starting the MP, should know they are a result of months or years of development and not due to the effects of the MP. The MP should prevent recurrence. Patients on the Marshall Protocol (MP) are somewhat less likely to get kidney stones, especially in later stages of the treatment, due to the restoration of proper vitamin D metabolism. Those patients who do develop kidney stones since starting the MP, should know they are a result of months or years of development and not due to the effects of the MP. The MP should prevent recurrence.
  
-===== Role of elevated 1,25-D =====+ 
 +===== Vitamin D ===== 
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 + 
 +==== Epidemiological studies ==== 
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 +According to a 2011 systematic review performed by the Cochrane Collaboration, "Vitamin D3 combined with calcium significantly increased nephrolithiasis [kidney stones]."(({{pubmed>long:21735411}}))  
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 +A 1980 epidemiological study of lifeguards in Israel (who presumably were exposed to a great deal of sunshine) found that 11 of 45 (24%) had proven kidney stones, a rate twenty times the incidence in the general population.(({{pubmed>long:7424691}})) 
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 + 
 +==== Role of elevated 1,25-D ====
  
 [{{ :home:diseases:549px-nefrolit.jpg?260|**Kidney stones may be caused by bacteria.**}}] [{{ :home:diseases:549px-nefrolit.jpg?260|**Kidney stones may be caused by bacteria.**}}]
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 Kidney stones are a common co-morbidity in patients who suffer from diseases noted for hypercalcemia including Crohn's disease and sarcoidosis. However, many normocalcemic patients with Th1 diseases have suffered from kidney stones and calcium deposition into the soft tissue as a result of excess levels of 1,25-D. At levels above about 42 pg/ml, the 1,25-D (generated by Th1 inflammation) begins to stimulate bone osteoclasts, causing bone to be resorbed, or dissolved, back into the bloodstream, which can lead to kidney stones. Kidney stones are a common co-morbidity in patients who suffer from diseases noted for hypercalcemia including Crohn's disease and sarcoidosis. However, many normocalcemic patients with Th1 diseases have suffered from kidney stones and calcium deposition into the soft tissue as a result of excess levels of 1,25-D. At levels above about 42 pg/ml, the 1,25-D (generated by Th1 inflammation) begins to stimulate bone osteoclasts, causing bone to be resorbed, or dissolved, back into the bloodstream, which can lead to kidney stones.
  
-A 1980 epidemiological study of lifeguards in Israel (who presumably were exposed to a great deal of sunshine) found that 11 of 45 (24%) had proven kidney stones, a rate  twenty times the incidence in the general population.(({{pubmed>long:7424691}}))+
  
 ===== Evidence of infectious cause ===== ===== Evidence of infectious cause =====
home/diseases/kidney_stones.txt · Last modified: 09.14.2022 by 127.0.0.1
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