This shows you the differences between two versions of the page.
Both sides previous revisionPrevious revisionNext revision | Previous revision | ||
home:diseases:lupus [01.18.2019] – [Patient interview] sallieq | home:diseases:lupus [09.14.2022] (current) – external edit 127.0.0.1 | ||
---|---|---|---|
Line 6: | Line 6: | ||
- | [[http:// | + | [[https:// |
===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
__ | __ | ||
- | Amyloid-DNA Composites of Bacterial Biofilms Stimulate Autoimmunity.__ | + | Amyloid-DNA Composites of Bacterial Biofilms Stimulate Autoimmunity.__ |
We found that a component of bacterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during biofilm formation. This interaction accelerated amyloid polymerization and created potent immunogenic complexes that activated immune cells, including dendritic cells, to produce cytokines such as type I interferons, | We found that a component of bacterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during biofilm formation. This interaction accelerated amyloid polymerization and created potent immunogenic complexes that activated immune cells, including dendritic cells, to produce cytokines such as type I interferons, | ||
- | __Familial aggregation of lupus and autoimmunity in an unusual multiplex pedigree.__ (({{pubmed> | + | __Familial aggregation of lupus and autoimmunity in an unusual multiplex pedigree.__ (({{pmid> |
OBJECTIVE: To evaluate an unusual pedigree with 8 members diagnosed with systemic lupus erythematosus (SLE) | OBJECTIVE: To evaluate an unusual pedigree with 8 members diagnosed with systemic lupus erythematosus (SLE) | ||
Line 26: | Line 26: | ||
- | < | + | < |
===== Diagnosis and Management ===== | ===== Diagnosis and Management ===== | ||
- | | + | |
- | Do classic blood biomarkers of JSLE identify active lupus nephritis? ...Binary logistic regression modeling demonstrated a combination of ESR, C3, white cell count, neutrophils, | + | Do classic blood biomarkers of JSLE identify active lupus nephritis? ...Binary logistic regression modeling demonstrated a combination of ESR, C3, white cell count, neutrophils, |
- | Potential Immune Biomarkers in Diagnosis and Clinical Management for Systemic Lupus Erythematosus.(({{pubmed> | + | Potential Immune Biomarkers in Diagnosis and Clinical Management for Systemic Lupus Erythematosus.(({{pmid> |
| | ||
- | Monitoring disease activity in systemic lupus erythematosus with single-molecule array digital ELISA quantification of serum interferon-α.(({{pubmed> | + | Monitoring disease activity in systemic lupus erythematosus with single-molecule array digital ELISA quantification of serum interferon-α.(({{pmid> |
- | Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, | + | Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, |
Line 45: | Line 45: | ||
Does minocycline have side effects or cause lupus? | Does minocycline have side effects or cause lupus? | ||
- | http:// | + | https:// |
The reports that Minocycline can induce lupus are laughable. Exactly how does a complex immune disease arise from the actions of a bacteriostatic antibiotic? Such a suggestion is ridiculous. The same goes for the suggestion that minocycline induces autoimmune hepatitis. Show us the beef, please - the molecular mechanisms. | The reports that Minocycline can induce lupus are laughable. Exactly how does a complex immune disease arise from the actions of a bacteriostatic antibiotic? Such a suggestion is ridiculous. The same goes for the suggestion that minocycline induces autoimmune hepatitis. Show us the beef, please - the molecular mechanisms. | ||
Line 64: | Line 64: | ||
==== See also ==== | ==== See also ==== | ||
- | [[https:// | + | [[https:// |
Line 70: | Line 70: | ||
< | < | ||
- | (({{pubmed> | + | (({{pmid> |
</ | </ | ||
Line 85: | Line 85: | ||
RESULTS: Hypertension, | RESULTS: Hypertension, | ||
- | CONCLUSIONS: | + | CONCLUSIONS: |
</ | </ | ||
Line 107: | Line 107: | ||
- | Staph is commonly found on the skin or in the nose and can cause infections ranging from pneumonia to food poisoning. But skin infections are the most common, experts say, and are more likely to occur if you have a cut or scratch, or have contact with a person or surface that has staph bacteria. //Dr Chowdhary' | + | Staph is commonly found on the skin or in the nose and can cause infections ranging from pneumonia to food poisoning. But skin infections are the most common, experts say, and are more likely to occur if you have a cut or scratch, or have contact with a person or surface that has staph bacteria. //Dr Chowdhary' |
</ | </ | ||
- | This Perspectives article discusses important questions about the use of ANA testing in both the clinical and research settings. | + | This Perspectives article discusses important questions about the use of ANA testing in both the clinical and research settings. |
- | This may indicate the importance of application of the test in a targeted way. (({{pubmed> | + | This may indicate the importance of application of the test in a targeted way. (({{pmid> |
- | ===== Recent | + | ===== Research ===== |
< | < | ||
- | UV exposure induces DNA damage, which can result in the formation of dimeric photoproducts involving neighboring pyrimidine bases (11–13). UV irradiation can also cause an accumulation of reactive oxygen species (ROS) in keratinocytes that results in oxidative damage to DNA, lipids, and proteins and can ultimately induce apoptosis (11, 13–15). Of importance, the oxidative damage to DNA bases can lead to formation of 8-hydroxyguanosine (8-OHG) which has been shown to be immunogenic in patients with lupus erythematosus (LE) and abundantly present in UV-induced LE lesions (16–18). | + | UV exposure induces DNA damage, which can result in the formation of dimeric photoproducts involving neighboring pyrimidine bases (11–13). UV irradiation can also cause an accumulation of reactive oxygen species (ROS) in keratinocytes that results in oxidative damage to DNA, lipids, and proteins and can ultimately induce apoptosis (11, 13–15). Of importance, the oxidative damage to DNA bases can lead to formation of 8-hydroxyguanosine (8-OHG) which has been shown to be immunogenic in patients with lupus erythematosus (LE) and abundantly present in UV-induced LE lesions (16–18). |
- | When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus. | + | When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus. |
- | Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, | + | Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, |
Furthermore, | Furthermore, | ||
+ | |||
+ | Calcium and vitamin D supplement intake may increase arterial stiffness in systemic lupus erythematosus patients. (({{pmid> | ||
+ | |||
+ | | ||
+ | |||
Line 163: | Line 168: | ||
lupus, Sjogren’s Syndrome | lupus, Sjogren’s Syndrome | ||
- | Read the [[http:// | + | Read the [[https:// |
< | < | ||
Line 181: | Line 186: | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
Line 216: | Line 222: | ||
* legacy content | * legacy content | ||
- | * http:// | + | * https:// |
broken link | broken link | ||
- | see also [[http:// | + | see also [[https:// |
- | ===== References ===== | + | ===== References =====</ |