You are here: Welcome to the MPKB » Welcome to the MPKB » Diseases » Systemic lupus erythematosus (SLE)
Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
home:diseases:lupus [02.09.2019] – [Recent Research] sallieqhome:diseases:lupus [09.14.2022] (current) – external edit 127.0.0.1
Line 6: Line 6:
  
  
-[[http://www.mayoclinic.org/diseases-conditions/lupus/basics/definition/con-20019676|Mayo Clinic overview]]+[[https://www.mayoclinic.org/diseases-conditions/lupus/basics/definition/con-20019676|Mayo Clinic overview]]
  
 ===== Evidence of infectious cause ===== ===== Evidence of infectious cause =====
 __ __
-Amyloid-DNA Composites of Bacterial Biofilms Stimulate Autoimmunity.__  (({{pubmed>long:26084027}}))  +Amyloid-DNA Composites of Bacterial Biofilms Stimulate Autoimmunity.__  (({{pmid>long:26084027}}))  
  
 We found that a component of bacterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during biofilm formation. This interaction accelerated amyloid polymerization and created potent immunogenic complexes that activated immune cells, including dendritic cells, to produce cytokines such as type I interferons, which are pathogenic in systemic lupus erythematosus (SLE).  We found that a component of bacterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during biofilm formation. This interaction accelerated amyloid polymerization and created potent immunogenic complexes that activated immune cells, including dendritic cells, to produce cytokines such as type I interferons, which are pathogenic in systemic lupus erythematosus (SLE). 
  
-__Familial aggregation of lupus and autoimmunity in an unusual multiplex pedigree.__ (({{pubmed>long:10405936}}))+__Familial aggregation of lupus and autoimmunity in an unusual multiplex pedigree.__ (({{pmid>long:10405936}}))
  
 OBJECTIVE: To evaluate an unusual pedigree with 8 members diagnosed with systemic lupus erythematosus (SLE)  OBJECTIVE: To evaluate an unusual pedigree with 8 members diagnosed with systemic lupus erythematosus (SLE) 
Line 26: Line 26:
  
  
-<blockquote>Now, researchers at Temple University School of Medicine (TUSM) have shown that bacterial communities that form biofilms play a role in the development of the autoimmune disease systemic lupus erythematosus -- a discovery that may provide important clues about several autoimmune ailments. (({{pubmed>long:26084027}}))  </blockquote>  +<blockquote>Now, researchers at Temple University School of Medicine (TUSM) have shown that bacterial communities that form biofilms play a role in the development of the autoimmune disease systemic lupus erythematosus -- a discovery that may provide important clues about several autoimmune ailments. (({{pmid>long:26084027}}))  </blockquote>  
  
 ===== Diagnosis and Management ===== ===== Diagnosis and Management =====
  
- Predictors of flare include rising anti-dsDNA antibody titres, proteinuria and CRP and B lymphocyte stimulator levels(({{pubmed>long:28013206}})) + Predictors of flare include rising anti-dsDNA antibody titres, proteinuria and CRP and B lymphocyte stimulator levels(({{pmid>long:28013206}})) 
  
-Do classic blood biomarkers of JSLE identify active lupus nephritis? ...Binary logistic regression modeling demonstrated a combination of ESR, C3, white cell count, neutrophils, lymphocytes and IgG to be best for the identification of active LN(({{pubmed>long:28385126}}))  +Do classic blood biomarkers of JSLE identify active lupus nephritis? ...Binary logistic regression modeling demonstrated a combination of ESR, C3, white cell count, neutrophils, lymphocytes and IgG to be best for the identification of active LN(({{pmid>long:28385126}}))  
  
-Potential Immune Biomarkers in Diagnosis and Clinical Management for Systemic Lupus Erythematosus.(({{pubmed>long:30581353}})) +Potential Immune Biomarkers in Diagnosis and Clinical Management for Systemic Lupus Erythematosus.(({{pmid>long:30581353}})) 
      
-Monitoring disease activity in systemic lupus erythematosus with single-molecule array digital ELISA quantification of serum interferon-α.(({{pubmed>long:30507062}}))  +Monitoring disease activity in systemic lupus erythematosus with single-molecule array digital ELISA quantification of serum interferon-α.(({{pmid>long:30507062}}))  
  
-Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial.  (({{pubmed>long:30477218}}))  +Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial.  (({{pmid>long:30477218}}))  
  
  
Line 45: Line 45:
 Does minocycline have side effects or cause lupus? Does minocycline have side effects or cause lupus?
  
-http://pediatrics.aappublications.org/cgi/content/extract/101/5/926+https://pediatrics.aappublications.org/cgi/content/extract/101/5/926
  
 The reports that Minocycline can induce lupus are laughable. Exactly how does a complex immune disease arise from the actions of a bacteriostatic antibiotic? Such a suggestion is ridiculous. The same goes for the suggestion that minocycline induces autoimmune hepatitis. Show us the beef, please - the molecular mechanisms. The reports that Minocycline can induce lupus are laughable. Exactly how does a complex immune disease arise from the actions of a bacteriostatic antibiotic? Such a suggestion is ridiculous. The same goes for the suggestion that minocycline induces autoimmune hepatitis. Show us the beef, please - the molecular mechanisms.
Line 64: Line 64:
 ==== See also ==== ==== See also ====
  
-[[https://rarediseases.org/rare-diseases/mixed-connective-tissue-disease-mctd/|Mixed Connective Tissue Disease]]  MCTD patients have rheumatic overlap syndrome plus anti-RNP antibodies.   (({{pubmed>long:25736140}}))    (({{pubmed>long:27353506}}))  +[[https://rarediseases.org/rare-diseases/mixed-connective-tissue-disease-mctd/|Mixed Connective Tissue Disease]]  MCTD patients have rheumatic overlap syndrome plus anti-RNP antibodies.   (({{pmid>long:25736140}}))    (({{pmid>long:27353506}}))  
  
  
Line 70: Line 70:
  
 <blockquote> BACKGROUND: Excessive activity of dendritic cells (DCs) is postulated as a central disease mechanism in Systemic Lupus Erythematosus (SLE). Vitamin D is known to reduce responsiveness of healthy donor DCs to the stimulatory effects of Type I IFN. As vitamin D deficiency is reportedly common in SLE, we hypothesized that vitamin D might play a regulatory role in the IFNalpha amplification loop in SLE. Our goals were to investigate the relationship between vitamin D levels and disease activity in SLE patients and to investigate the effects of vitamin D on DC activation and expression of IFNalpha-regulated genes in vitro.  <blockquote> BACKGROUND: Excessive activity of dendritic cells (DCs) is postulated as a central disease mechanism in Systemic Lupus Erythematosus (SLE). Vitamin D is known to reduce responsiveness of healthy donor DCs to the stimulatory effects of Type I IFN. As vitamin D deficiency is reportedly common in SLE, we hypothesized that vitamin D might play a regulatory role in the IFNalpha amplification loop in SLE. Our goals were to investigate the relationship between vitamin D levels and disease activity in SLE patients and to investigate the effects of vitamin D on DC activation and expression of IFNalpha-regulated genes in vitro. 
- (({{pubmed>long:20169063}}))+ (({{pmid>long:20169063}}))
 </blockquote> </blockquote>
  
Line 85: Line 85:
  
 RESULTS: Hypertension, triglycerides and insulin resistance (determined by homeostasis model assessment of insulin resistance) and C-reactive protein (CRP) were increased in SLE (P < 0.01) while smoking, LDL, high density lipoprotein (HDL) did not differ between groups. Low levels of anti-PC IgM (lowest tertile) were more common in SLE patients than in controls (P = 0.0022). IMT and cIMa did not differ significantly between groups. However, plaques were more often found in SLE patients (P = 0.029). Age, LDL and IgM anti-PC (lowest tertile) were independently associated with plaque occurrence in SLE. Further, in the left carotid arteries echoluscent plaques (grade 1) were more prevalent in SLE as compared to controls (P < 0.016). RESULTS: Hypertension, triglycerides and insulin resistance (determined by homeostasis model assessment of insulin resistance) and C-reactive protein (CRP) were increased in SLE (P < 0.01) while smoking, LDL, high density lipoprotein (HDL) did not differ between groups. Low levels of anti-PC IgM (lowest tertile) were more common in SLE patients than in controls (P = 0.0022). IMT and cIMa did not differ significantly between groups. However, plaques were more often found in SLE patients (P = 0.029). Age, LDL and IgM anti-PC (lowest tertile) were independently associated with plaque occurrence in SLE. Further, in the left carotid arteries echoluscent plaques (grade 1) were more prevalent in SLE as compared to controls (P < 0.016).
-CONCLUSIONS: Plaque occurrence in the carotid arteries is increased in SLE and is independently associated with age, LDL and low anti-PC levels. Vulnerable plaques were more common in SLE. Anti-PC could be a novel risk marker also with a therapeutic potential in SLE. (({{pubmed>long:21092251}}))+CONCLUSIONS: Plaque occurrence in the carotid arteries is increased in SLE and is independently associated with age, LDL and low anti-PC levels. Vulnerable plaques were more common in SLE. Anti-PC could be a novel risk marker also with a therapeutic potential in SLE. (({{pmid>long:21092251}}))
 </blockquote> </blockquote>
  
Line 107: Line 107:
  
  
-Staph is commonly found on the skin or in the nose and can cause infections ranging from pneumonia to food poisoning. But skin infections are the most common, experts say, and are more likely to occur if you have a cut or scratch, or have contact with a person or surface that has staph bacteria. //Dr Chowdhary's studies//  (({{pubmed>long:18793002}}))  (({{pubmed>long:22798666}}))  (({{pubmed>long:22859356}}))  (({{pubmed>long:25369985}}))  (({{pubmed>long:27520797}}))  (({{pubmed>long:27365370}}))+Staph is commonly found on the skin or in the nose and can cause infections ranging from pneumonia to food poisoning. But skin infections are the most common, experts say, and are more likely to occur if you have a cut or scratch, or have contact with a person or surface that has staph bacteria. //Dr Chowdhary's studies//  (({{pmid>long:18793002}}))  (({{pmid>long:22798666}}))  (({{pmid>long:22859356}}))  (({{pmid>long:25369985}}))  (({{pmid>long:27520797}}))  (({{pmid>long:27365370}}))
 </blockquote> </blockquote>
  
- This Perspectives article discusses important questions about the use of ANA testing in both the clinical and research settings.   (({{pubmed>long:28541299}}))  + This Perspectives article discusses important questions about the use of ANA testing in both the clinical and research settings.   (({{pmid>long:28541299}}))  
  
  
-This may indicate the importance of application of the test in a targeted way. (({{pubmed>long:27221374}}))  +This may indicate the importance of application of the test in a targeted way. (({{pmid>long:27221374}}))  
  
-===== Recent Research =====+===== Research =====
  
 <blockquote>Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus (SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known. This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, and systemic flare induction. In addition, the role of the circadian clock is discussed. Evidence is compared in healthy individuals and SLE patients as well as in wild-type and lupus-prone mice. Further research is needed into the effects of UV light on cutaneous and systemic immune responses to understand how to prevent UV-light mediated lupus flares. <blockquote>Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus (SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known. This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment, and systemic flare induction. In addition, the role of the circadian clock is discussed. Evidence is compared in healthy individuals and SLE patients as well as in wild-type and lupus-prone mice. Further research is needed into the effects of UV light on cutaneous and systemic immune responses to understand how to prevent UV-light mediated lupus flares.
  
-UV exposure induces DNA damage, which can result in the formation of dimeric photoproducts involving neighboring pyrimidine bases (11–13). UV irradiation can also cause an accumulation of reactive oxygen species (ROS) in keratinocytes that results in oxidative damage to DNA, lipids, and proteins and can ultimately induce apoptosis (11, 13–15). Of importance, the oxidative damage to DNA bases can lead to formation of 8-hydroxyguanosine (8-OHG) which has been shown to be immunogenic in patients with lupus erythematosus (LE) and abundantly present in UV-induced LE lesions (16–18).  (({{pubmed>long:30405625}})) </blockquote> +UV exposure induces DNA damage, which can result in the formation of dimeric photoproducts involving neighboring pyrimidine bases (11–13). UV irradiation can also cause an accumulation of reactive oxygen species (ROS) in keratinocytes that results in oxidative damage to DNA, lipids, and proteins and can ultimately induce apoptosis (11, 13–15). Of importance, the oxidative damage to DNA bases can lead to formation of 8-hydroxyguanosine (8-OHG) which has been shown to be immunogenic in patients with lupus erythematosus (LE) and abundantly present in UV-induced LE lesions (16–18).  (({{pmid>long:30405625}})) </blockquote> 
  
-When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus.  (({{pubmed>long:30613100}}))  +When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus.  (({{pmid>long:30613100}}))  
  
-Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications.  (({{pubmed>long:30305312}}))  +Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications.  (({{pmid>long:30305312}}))  
  
 Furthermore, curli (and extracellular DNA) of enteric biofilms potentiate the autoimmune disease systemic lupus erythematosus (SLE) and promote the fibrillization of the pathogenic amyloid α-synuclein, which is implicated in Parkinson's disease. Homologues of curli-encoding genes are found in four additional bacterial phyla, suggesting that the biomedical implications involved with enteric biofilms are applicable to numerous bacterial species. Furthermore, curli (and extracellular DNA) of enteric biofilms potentiate the autoimmune disease systemic lupus erythematosus (SLE) and promote the fibrillization of the pathogenic amyloid α-synuclein, which is implicated in Parkinson's disease. Homologues of curli-encoding genes are found in four additional bacterial phyla, suggesting that the biomedical implications involved with enteric biofilms are applicable to numerous bacterial species.
  
-Calcium and vitamin D supplement intake may increase arterial stiffness in systemic lupus erythematosus patients. (({{pubmed>long:30628012}})) +Calcium and vitamin D supplement intake may increase arterial stiffness in systemic lupus erythematosus patients. (({{pmid>long:30628012}}))  
 + 
 + Patients receiving the highest dose of olmesartan (40 and 80 mg) had an inward carotid remodeling and were shifted toward a lower elastic modulus at a given circumferential wall stress, indicating an improvement in the intrinsic elastic properties of the carotid artery wall material. These data suggest that 40 and 80 mg olmesartan were able to significantly remodel and destiffen the arterial wall material during long-term treatment, partly independently of blood pressure, compared with 20 mg. (({{pmid>long:25001274}}))
  
  
Line 166: Line 168:
 lupus, Sjogren’s Syndrome lupus, Sjogren’s Syndrome
  
-Read the [[http://bacteriality.com/2008/07/02/interview23/|interview]]+Read the [[https://bacteriality.com/2008/07/02/interview23/|interview]]
  
 <html></div></div> <html></div></div>
Line 184: Line 186:
  
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
Line 219: Line 222:
  
   * legacy content   * legacy content
-  * http://www.marshallprotocol.com/view_topic.php?id=10933&forum_id=32&jump_to=132470#p132470 f118+  * https://www.marshallprotocol.com/view_topic.php?id=10933&forum_id=32&jump_to=132470#p132470 f118
  
  
 broken link  broken link 
-see also [[http://www.neuroscientistnews.com/research-news/research-team-finds-bacterial-biofilms-may-play-role-lupus-ms-other-auto-immune|neuroscientistnews]] +see also [[https://www.neuroscientistnews.com/research-news/research-team-finds-bacterial-biofilms-may-play-role-lupus-ms-other-auto-immune|neuroscientistnews]] 
-===== References =====+===== References =====</nodisp> 
home/diseases/lupus.txt · Last modified: 09.14.2022 by 127.0.0.1
© 2015, Autoimmunity Research Foundation. All Rights Reserved.