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home:diseases:lupus [02.09.2019]
sallieq [Recent Research]
home:diseases:lupus [02.10.2019] (current)
sallieq [Recent Research]
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 This may indicate the importance of application of the test in a targeted way. (({{pubmed>​long:​27221374}}))  ​ This may indicate the importance of application of the test in a targeted way. (({{pubmed>​long:​27221374}}))  ​
  
-===== Recent ​Research =====+===== Research =====
  
 <​blockquote>​Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus (SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known. This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment,​ and systemic flare induction. In addition, the role of the circadian clock is discussed. Evidence is compared in healthy individuals and SLE patients as well as in wild-type and lupus-prone mice. Further research is needed into the effects of UV light on cutaneous and systemic immune responses to understand how to prevent UV-light mediated lupus flares. <​blockquote>​Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus (SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known. This review covers evidence in both human and murine systems for the impacts of UV light on DNA damage, apoptosis, autoantigen exposure, cytokine production, inflammatory cell recruitment,​ and systemic flare induction. In addition, the role of the circadian clock is discussed. Evidence is compared in healthy individuals and SLE patients as well as in wild-type and lupus-prone mice. Further research is needed into the effects of UV light on cutaneous and systemic immune responses to understand how to prevent UV-light mediated lupus flares.
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 Calcium and vitamin D supplement intake may increase arterial stiffness in systemic lupus erythematosus patients. (({{pubmed>​long:​30628012}})) ​ Calcium and vitamin D supplement intake may increase arterial stiffness in systemic lupus erythematosus patients. (({{pubmed>​long:​30628012}})) ​
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 + ​Patients receiving the highest dose of olmesartan (40 and 80 mg) had an inward carotid remodeling and were shifted toward a lower elastic modulus at a given circumferential wall stress, indicating an improvement in the intrinsic elastic properties of the carotid artery wall material. These data suggest that 40 and 80 mg olmesartan were able to significantly remodel and destiffen the arterial wall material during long-term treatment, partly independently of blood pressure, compared with 20 mg. (({{pubmed>​long:​25001274}}))
  
  
home/diseases/lupus.txt · Last modified: 02.10.2019 by sallieq
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