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====== Chronic Lyme disease ====== | ====== Chronic Lyme disease ====== | ||
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The Marshall Protocol is an attempt to do the opposite. Rather than use immunosuppression, | The Marshall Protocol is an attempt to do the opposite. Rather than use immunosuppression, | ||
- | Autoimmunity Research Foundation has been granted by the FDA [[http:// | + | Autoimmunity Research Foundation has been granted by the FDA [[https:// |
- | + | ===== Managing symptoms while on the Marshall Protocol ===== | |
- | + | ||
- | =====Managing symptoms while on the Marshall Protocol ===== | + | |
* **[[home: | * **[[home: | ||
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What we who are a part of this forum, who stuck with the protocol long enough, who endured the IP and were able to keep a doctor, report is that this has a better than 50% success rate. | What we who are a part of this forum, who stuck with the protocol long enough, who endured the IP and were able to keep a doctor, report is that this has a better than 50% success rate. | ||
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- | =====Antibiotic treatments===== | ||
- | < | ||
- | One of the reasons why chronic Lyme disease is so contentious is that advocates for it strongly believe in the value of high-dose antibiotic therapies, any treatment which uses antibiotics at a large enough dose that the immune response is suppressed more than it is not. High-dose antibiotics are ineffective, | ||
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- | ==== Doxycycline ==== | ||
- | < | ||
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- | Although the MP antibiotic minocycline is also a tetracycline, | ||
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- | ==== Cephlasporins including Rocephin ==== | ||
- | < | ||
- | {{section>: | ||
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- | ===== Other treatments ===== | ||
- | * **[[home: | ||
- | * **hydrogen peroxide** – Delivered intravenously. The theory is that hydrogen peroxide releases extra oxygen inside the body, killing microbes. This [[http:// | ||
- | * **[[home: | ||
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===== Role of infection ===== | ===== Role of infection ===== | ||
- | ====Caused by multiple microbes ==== | + | ==== Caused by multiple microbes ==== |
< | < | ||
- | |||
< | < | ||
//**D.C. Owen**// (({{pubmed> | //**D.C. Owen**// (({{pubmed> | ||
+ | //**D.C. Owen**// (({{pbmid> | ||
</ | </ | ||
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W. Ian Lipkin' | W. Ian Lipkin' | ||
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+ | We collected data from an online survey of 200 of our patients, which evaluated the efficacy of dapsone (diaminodiphenyl sulfone, ie, DDS) combined with other antibiotics and agents that disrupt biofilms for the treatment of chronic Lyme disease/ | ||
=== Australian ticks === | === Australian ticks === | ||
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Human Tick-Borne Diseases in Australia. | Human Tick-Borne Diseases in Australia. | ||
+ | ==== Borrelia and the VDR ==== | ||
- | ==== Borrelia and the VDR ==== | ||
< | < | ||
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Olmesartan is the main medication used by the Marshall Protocol and is believed to act as a VDR agonist, counteracting // | Olmesartan is the main medication used by the Marshall Protocol and is believed to act as a VDR agonist, counteracting // | ||
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[{{ : | [{{ : | ||
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==== Different proteins in cerebrospinal fluid ==== | ==== Different proteins in cerebrospinal fluid ==== | ||
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Greco //et al.// claimed to find a variety of autoantibodies including antiphospholipid antibodies in patients with chronic Lyme disease.(({{pubmed> | Greco //et al.// claimed to find a variety of autoantibodies including antiphospholipid antibodies in patients with chronic Lyme disease.(({{pubmed> | ||
- | ===== Psychosomatic explanations for disease ===== | ||
- | < | ||
- | {{section>: | ||
+ | ===== Ticks, what to do when bitten ===== | ||
+ | < | ||
+ | Marshall Protocol patients who develop a bulls-eye rash after a tick bite or who think a tick bite has put them at risk for Lyme disease should ask their physician about taking 100mg of minocycline twice daily for 30 days. | ||
===== Herxheimer reaction ===== | ===== Herxheimer reaction ===== | ||
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One of the significant distinctions between a herx reaction in patients taking high-dose antibiotics and those on the MP is the length of that reaction. While it is common to hear Lyme patients experience a herx response for several weeks, patients on the MP may experience sustained immunopathology over the course of years. While this makes the MP harder to complete, the length of the treatment before a decrease in symptoms may be a tribute to how sick some patients with chronic Lyme or any other chronic disease truly are. | One of the significant distinctions between a herx reaction in patients taking high-dose antibiotics and those on the MP is the length of that reaction. While it is common to hear Lyme patients experience a herx response for several weeks, patients on the MP may experience sustained immunopathology over the course of years. While this makes the MP harder to complete, the length of the treatment before a decrease in symptoms may be a tribute to how sick some patients with chronic Lyme or any other chronic disease truly are. | ||
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- | =====Ticks, what to do when bitten ===== | ||
- | < | ||
- | Marshall Protocol patients who develop a bulls-eye rash after a tick bite or who think a tick bite has put them at risk for Lyme disease should ask their physician about taking 100mg of minocycline twice daily for 30 days. | ||
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- | =====Chronic controversy over chronic Lyme disease ===== | ||
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- | < | ||
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- | //**David Whelan** wrote // Ticks aren't the only parasites living off patients in borreliosis-prone areas | ||
- | </ | ||
- | |||
- | While there is general agreement on the optimal treatment for early Lyme disease, there is considerable controversy over the existence, prevalence, diagnostic criteria, and treatment of chronic Lyme disease. | ||
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- | Over the past decade, two opposing camps have emerged in the battle over Lyme. One camp is represented by the International Lyme and Associated Diseases Society (ILADS), which argues that Lyme disease is not rare because its spread is facilitated by rodents, deer and birds, and can be found in an unpredictable distribution around the world accompanied by other tick-borne coinfections that may complicate the clinical presentation. According to the ILADS, tick bites often go unnoticed and commercial laboratory testing for Lyme disease is inaccurate. Consequently, | ||
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- | The opposing camp is represented by the Infectious Diseases Society of America (IDSA), which maintains that Lyme disease is a rare illness localized to well-defined areas of the world. According to the IDSA, the disease is "hard to catch and easy to cure" because the infection is rarely encountered, | ||
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- | This mainstream view is exemplified by a 2007 review in the //New England Journal of Medicine//, which noted the diagnosis of chronic Lyme disease is used by a few physicians despite a lack of " | ||
- | |||
- | < | ||
- | |||
- | //**L.H. Sigal**// (({{pubmed> | ||
- | |||
- | Groups of patients, patient advocates, and the small number of physicians who support the concept of chronic Lyme disease have organized to lobby for recognition of this diagnosis, as well as to argue for insurance coverage of long-term antibiotic therapy, which most insurers deny, as it is at odds with the guidelines of the major medical organizations. | ||
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- | The term " | ||
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- | The net result of this controversy is that many doctors [[http:// | ||
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===== Patient interviews | ===== Patient interviews | ||
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< | < | ||
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Lyme, //Babesia// | Lyme, //Babesia// | ||
- | Read the [[http:// | + | Read the [[https:// |
< | < | ||
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Lyme disease, irritable bowel syndrome/ | Lyme disease, irritable bowel syndrome/ | ||
- | Read the [[http:// | + | Read the [[https:// |
< | < | ||
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Post Treatment Lyme Disease Syndrome (PTLDS) | Post Treatment Lyme Disease Syndrome (PTLDS) | ||
- | Read the [[http:// | + | Read the [[https:// |
< | < | ||
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Lyme, myoclonus | Lyme, myoclonus | ||
- | Read the [[http:// | + | Read the [[https:// |
< | < | ||
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chronic borreliosis (" | chronic borreliosis (" | ||
- | Read the [[http:// | + | Read the [[https:// |
< | < | ||
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</ | </ | ||
+ | ===== Psychosomatic explanations for disease ===== | ||
+ | < | ||
+ | {{section>: | ||
+ | |||
+ | ===== Research ===== | ||
+ | |||
+ | Many antimicrobial agents (antibiotics, | ||
===== Read more ===== | ===== Read more ===== | ||
- | * According to a [[http:// | + | * According to a [[https:// |
- | * [[http:// | + | * [[https:// |
- | * [[http:// | + | * [[https:// |
* SPECT scans are abnormal in chronic Lyme patients – According to a 2012 study, 75% of brain SPECT scans are abnormal in patients with chronic Lyme disease.(({{pubmed> | * SPECT scans are abnormal in chronic Lyme patients – According to a 2012 study, 75% of brain SPECT scans are abnormal in patients with chronic Lyme disease.(({{pubmed> | ||
+ | ===== Controversy over chronic Lyme disease ===== | ||
+ | < | ||
+ | |||
+ | //**David Whelan** wrote // Ticks aren't the only parasites living off patients in borreliosis-prone areas | ||
+ | </ | ||
+ | |||
+ | While there is general agreement on the optimal treatment for early Lyme disease, there is considerable controversy over the existence, prevalence, diagnostic criteria, and treatment of chronic Lyme disease. | ||
+ | |||
+ | Over the past decade, two opposing camps have emerged in the battle over Lyme. One camp is represented by the International Lyme and Associated Diseases Society (ILADS), which argues that Lyme disease is not rare because its spread is facilitated by rodents, deer and birds, and can be found in an unpredictable distribution around the world accompanied by other tick-borne coinfections that may complicate the clinical presentation. According to the ILADS, tick bites often go unnoticed and commercial laboratory testing for Lyme disease is inaccurate. Consequently, | ||
+ | |||
+ | The opposing camp is represented by the Infectious Diseases Society of America (IDSA), which maintains that Lyme disease is a rare illness localized to well-defined areas of the world. According to the IDSA, the disease is "hard to catch and easy to cure" because the infection is rarely encountered, | ||
+ | |||
+ | This mainstream view is exemplified by a 2007 review in the //New England Journal of Medicine//, which noted the diagnosis of chronic Lyme disease is used by a few physicians despite a lack of " | ||
+ | |||
+ | < | ||
+ | |||
+ | //**L.H. Sigal**// (({{pubmed> | ||
+ | |||
+ | Groups of patients, patient advocates, and the small number of physicians who support the concept of chronic Lyme disease have organized to lobby for recognition of this diagnosis, as well as to argue for insurance coverage of long-term antibiotic therapy, which most insurers deny, as it is at odds with the guidelines of the major medical organizations. | ||
+ | |||
+ | The term " | ||
+ | |||
+ | The net result of this controversy is that many doctors [[https:// | ||
+ | |||
+ | |||
+ | ==== Treatments sometimes used by those not on MP ==== | ||
+ | |||
+ | * **[[home: | ||
+ | * **hydrogen peroxide** – Delivered intravenously. The theory is that hydrogen peroxide releases extra oxygen inside the body, killing microbes. This [[https:// | ||
+ | * **[[home: | ||
+ | |||
+ | Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Some highly active essential oils were found to have excellent anti-biofilm ability | ||
+ | |||
+ | === Disulfiram === | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | Screening to identify potent candidate drugs that can target the Borrelia persisters.(({{pubmed> | ||
+ | |||
+ | Not suitable for children (({{pubmed> | ||
+ | |||
+ | may be possible for some adolescents (({{pubmed> | ||
+ | |||
+ | === === | ||
+ | |||
+ | < | ||
+ | I have not filled the script yet but will update my progress thread if/ when I embark on this method.</ | ||
+ | |||
+ | === Antibiotic treatments === | ||
+ | < | ||
+ | One of the reasons why chronic Lyme disease is so contentious is that advocates for it strongly believe in the value of high-dose antibiotic therapies, any treatment which uses antibiotics at a large enough dose that the immune response is suppressed more than it is not. High-dose antibiotics are ineffective, | ||
+ | |||
+ | |||
+ | == Doxycycline == | ||
+ | < | ||
+ | |||
+ | Although the MP antibiotic minocycline is also a tetracycline, | ||
+ | |||
+ | |||
+ | == Cephlasporins including Rocephin == | ||
+ | < | ||
+ | {{section>: | ||
+ | |||
+ | == Multiple ABx == | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of **3** antibiotic drugs in combination, | ||
+ | |||
+ | the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pubmed> | ||
+ | |||
+ | Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline. | ||
+ | |||
+ | Sulpha drugs and their combinations(({{pubmed> | ||
{{tag> | {{tag> | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
+ | |||
+ | https:// | ||
+ | |||
//broken link removed// | //broken link removed// | ||
- | Lyme patients [[http:// | + | Lyme patients [[https:// |
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< | < | ||
- | Antibodies linked to long-term Lyme symptoms: Some patients with Lyme disease still show symptoms long after the... | + | Antibodies linked to long-term Lyme symptoms: Some patients with Lyme disease still show symptoms long after the... |
From: Frenchie | From: Frenchie | ||
Date: 2011-08-09 07:08:55 | Date: 2011-08-09 07:08:55 | ||
- | Reply: | + | Reply: |
Now Armin Alaedini at Weill Cornell Medical College in New York and his colleagues have found that patients diagnosed with post-Lyme disease | Now Armin Alaedini at Weill Cornell Medical College in New York and his colleagues have found that patients diagnosed with post-Lyme disease | ||
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This finding suggests that patients with chronic symptoms have experienced a prolonged infection, caused by microbes that have evaded | This finding suggests that patients with chronic symptoms have experienced a prolonged infection, caused by microbes that have evaded | ||
- | http:// | + | https:// |
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From: Dr Trevor Marshall | From: Dr Trevor Marshall | ||
Date: 2011-08-09 07:16:27 | Date: 2011-08-09 07:16:27 | ||
- | Reply: | + | Reply: |
The group at Weill Cornell did not consider the possibility that their testing procedures might be confused by the thousands of other species present along with the Borrelia. I read this report, and although not junk science, it is of little practical use until their procedures become more precise, IMO. They really don't have much of a clue. | The group at Weill Cornell did not consider the possibility that their testing procedures might be confused by the thousands of other species present along with the Borrelia. I read this report, and although not junk science, it is of little practical use until their procedures become more precise, IMO. They really don't have much of a clue. | ||
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|**Timing** | |**Timing** | ||
|**Conventional explanation for cause** | |**Conventional explanation for cause** | ||
- | |**Laboratory tests** | + | |**Laboratory tests** |
|**Diagnosis** | |**Diagnosis** | ||
|**Controversy over legitimacy of diagnosis** | |**Controversy over legitimacy of diagnosis** | ||
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< | < | ||
- | If you look at the master genome list at [[http:// | + | If you look at the master genome list at [[https:// |
Unfortunately the Borrelia genome has proven too complex for many of our institutions to fully assimilate, and this is an excellent example. Both groups are correct, but they are looking at the species in different ways. | Unfortunately the Borrelia genome has proven too complex for many of our institutions to fully assimilate, and this is an excellent example. Both groups are correct, but they are looking at the species in different ways. | ||
A similar situation exists within the Mycoplasma species. Look for example, at this species comparison: | A similar situation exists within the Mycoplasma species. Look for example, at this species comparison: | ||
- | [[http:// | + | [[https:// |
The rapid pace of advance in science' | The rapid pace of advance in science' | ||
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Trevor | Trevor | ||
</ | </ | ||
+ | |||
+ | ==== Treatments sometimes used by those not on MP ==== | ||
+ | |||
+ | * **[[home: | ||
+ | * **hydrogen peroxide** – Delivered intravenously. The theory is that hydrogen peroxide releases extra oxygen inside the body, killing microbes. This [[https:// | ||
+ | * **[[home: | ||
+ | |||
+ | Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Some highly active essential oils were found to have excellent anti-biofilm ability | ||
+ | |||
+ | === Disulfiram === | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | Screening to identify potent candidate drugs that can target the Borrelia persisters.(({{pubmed> | ||
+ | |||
+ | Not suitable for children (({{pubmed> | ||
+ | |||
+ | May be for adolescents (({{pubmed> | ||
+ | |||
+ | === === | ||
+ | |||
+ | < | ||
+ | I have not filled the script yet but will update my progress thread if/ when I embark on this method.</ | ||
+ | |||
+ | === Antibiotic treatments === | ||
+ | < | ||
+ | One of the reasons why chronic Lyme disease is so contentious is that advocates for it strongly believe in the value of high-dose antibiotic therapies, any treatment which uses antibiotics at a large enough dose that the immune response is suppressed more than it is not. High-dose antibiotics are ineffective, | ||
+ | |||
+ | |||
+ | == Doxycycline == | ||
+ | < | ||
+ | |||
+ | Although the MP antibiotic minocycline is also a tetracycline, | ||
+ | |||
+ | |||
+ | == Cephlasporins including Rocephin == | ||
+ | < | ||
+ | {{section>: | ||
+ | |||
+ | == Multiple Antibiotics == | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of **3** antibiotic drugs in combination | ||
+ | |||
+ | the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pubmed> | ||
+ | |||
+ | Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline. | ||
+ | |||
+ | Sulpha drugs and their combinations(({{pubmed> | ||
===== References ===== | ===== References ===== | ||
+ |