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home:diseases:lyme [08.12.2019] – sallieqhome:diseases:lyme [08.12.2019] – [Chronic controversy over chronic Lyme disease] sallieq
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-=====Chronic controversy over chronic Lyme disease =====+===== Controversy over chronic Lyme disease =====
  
 <blockquote>Lyme disease, with 20,000 cases reported annually, ranks low on the list of the most prevalent infectious diseases. But it ranks first in rancor generated in the medical community. <blockquote>Lyme disease, with 20,000 cases reported annually, ranks low on the list of the most prevalent infectious diseases. But it ranks first in rancor generated in the medical community.
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 The net result of this controversy is that many doctors [[http://www.ama-assn.org/amednews/2008/06/09/hlsa0609.htm|try to avoid]] having Lyme patients in their practice. The net result of this controversy is that many doctors [[http://www.ama-assn.org/amednews/2008/06/09/hlsa0609.htm|try to avoid]] having Lyme patients in their practice.
 +
 +
 +==== Treatments sometimes used by those not on MP ====
 +
 +  * **[[home:othertreatments:colloidal_silver|colloidal silver]]** – While colloidal silver is marketed for internal and external use as an alternative medical remedy, there is no scientific evidence of its effectiveness in vivo for any medical condition. Also, it can [[http://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html|permanently turn]] your skin silver.
 +  * **hydrogen peroxide** – Delivered intravenously. The theory is that hydrogen peroxide releases extra oxygen inside the body, killing microbes. This [[http://www.cbsnews.com/stories/2005/01/12/60II/main666489.shtml|dangerous therapy]] is based on an overly simplistic view of the body's metabolism. There are no large-scale studies proving hydrogen peroxide is effective.
 +  * **[[home:othertreatments:rife|Rife]]** – There is no scientific evidence that the use of a Rife device has the intended effect on infectious bacteria. Instead, most patients using Rife are likely administering themselves nothing more than an expensive placebo.
 +
 +Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Some highly active essential oils were found to have excellent anti-biofilm ability  (({{pubmed>long:    29075628}}))
 +
 +=== Disulfiram ===
 +
 +[[https://www.lymedisease.org/disulfiram-kinderlehrer/?fbclid=IwAR2CQcqG97LK_qsGh1QZD37VrD2oQecR70cZKyXlidgdMIyGOWcPgKdLAWA|Activity of disulfiram]]
 +
 +[[https://www.mdpi.com/2079-6382/8/2/72/htm?fbclid=IwAR3l19rcHXqfvUcYXUqlk9F18kZqwGX_QsiJPdgfPrIUYe15SUAAGKltfTo|Three cases]]
 +
 +[[https://clinicaltrials.gov/ct2/show/NCT03891667|Study to examine the safety of disulfiram among patients with post-treatment Lyme disease Sx]]
 +
 +Screening to identify potent candidate drugs that can target the Borrelia persisters.(({{pubmed>long:27103785}}))
 +
 +Not suitable for children (({{pubmed>long:6470872}})), (({{pubmed>long:9093309}}))
 +
 +May be for adolescents (({{pubmed>long:27613346}}))
 +
 +===   ===
 +
 +<blockquote>My doc just prescribed this for me but with a big warning to ramp VERY slowly due to immunopathology, IP/ Herx can be powerful.
 +I have not filled the script yet but will update my progress thread if/ when I embark on this method.</blockquote>
 +
 +=== Antibiotic treatments ===
 +<mainarticle>  [[home:othertreatments:antibacterials:highdose|High-dose antibiotic therapies]]</article>
 +One of the reasons why chronic Lyme disease is so contentious is that advocates for it strongly believe in the value of high-dose antibiotic therapies, any treatment which uses antibiotics at a large enough dose that the immune response is suppressed more than it is not. High-dose antibiotics are ineffective, and this is well-reflected in the published literature. The short-term improvement and long-term crash some patients feel on high-dose antibiotics is due to the fact these drugs interfere with immune activity in dose dependent fashion. With a weakened inflammatory response, a patient's symptoms may temporarily improve, but not because the pathogenic bacteria which drive disease have been eradicated. As a result, these protocols do not generate sustained immunopathology.
 +
 +
 +== Doxycycline ==
 +<mainarticle> [[home:othertreatments:antibacterials:doxycycline|Doxycycline]]</article>
 +
 +Although the MP antibiotic minocycline is also a tetracycline, doxycycline and minocycline are significantly different from each other – both in terms of structure and function. Doxycycline's effectiveness over short periods of time is due in part to the relatively high doses at which it is typically administered: 200 mg per day. Doxycycline does not kill as wide a range of bacteria as minocycline. For example, doxycycline doesn't kill //Staphylococcus//, a genus found in at least three recent studies in which the human microbiome was sequenced.
 +
 +
 +== Cephlasporins including Rocephin ==
 +<mainarticle> [[home:othertreatments:antibacterials:betalactams|Beta-lactam antibiotics]]</article>
 +{{section>:home:othertreatments:antibacterials:betalactams#cephalosporins&noheader&firstseconly}}
 +
 +== Multiple Antibiotics ==
 +
 +[[http://www.discoverymedicine.com/Jie-Feng/2019/03/persister-biofilm-microcolony-borrelia-burgdorferi-causes-severe-lyme-arthritis-in-mouse-model/|persistent disease: compared efficacy of 2-drug and 3-drug combination]]
 +
 +Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of **3** antibiotic drugs in combination
 +
 + the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pubmed>long:    12073540}}))
 +
 +Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline.  (({{pubmed>long:    25806811}}))
 +
 +Sulpha drugs and their combinations(({{pubmed>long:28327498}}))
  
 {{tag>diseases}} {{tag>diseases}}
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 </blockquote> </blockquote>
  
-===== Treatments sometimes used by those not on MP =====+==== Treatments sometimes used by those not on MP ====
  
   * **[[home:othertreatments:colloidal_silver|colloidal silver]]** – While colloidal silver is marketed for internal and external use as an alternative medical remedy, there is no scientific evidence of its effectiveness in vivo for any medical condition. Also, it can [[http://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html|permanently turn]] your skin silver.   * **[[home:othertreatments:colloidal_silver|colloidal silver]]** – While colloidal silver is marketed for internal and external use as an alternative medical remedy, there is no scientific evidence of its effectiveness in vivo for any medical condition. Also, it can [[http://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html|permanently turn]] your skin silver.
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 Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Some highly active essential oils were found to have excellent anti-biofilm ability  (({{pubmed>long:    29075628}})) Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Some highly active essential oils were found to have excellent anti-biofilm ability  (({{pubmed>long:    29075628}}))
  
-==== Disulfiram ====+=== Disulfiram ===
  
 [[https://www.lymedisease.org/disulfiram-kinderlehrer/?fbclid=IwAR2CQcqG97LK_qsGh1QZD37VrD2oQecR70cZKyXlidgdMIyGOWcPgKdLAWA|Activity of disulfiram]] [[https://www.lymedisease.org/disulfiram-kinderlehrer/?fbclid=IwAR2CQcqG97LK_qsGh1QZD37VrD2oQecR70cZKyXlidgdMIyGOWcPgKdLAWA|Activity of disulfiram]]
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 I have not filled the script yet but will update my progress thread if/ when I embark on this method.</blockquote> I have not filled the script yet but will update my progress thread if/ when I embark on this method.</blockquote>
  
-=====Antibiotic treatments=====+=== Antibiotic treatments ===
 <mainarticle>  [[home:othertreatments:antibacterials:highdose|High-dose antibiotic therapies]]</article> <mainarticle>  [[home:othertreatments:antibacterials:highdose|High-dose antibiotic therapies]]</article>
 One of the reasons why chronic Lyme disease is so contentious is that advocates for it strongly believe in the value of high-dose antibiotic therapies, any treatment which uses antibiotics at a large enough dose that the immune response is suppressed more than it is not. High-dose antibiotics are ineffective, and this is well-reflected in the published literature. The short-term improvement and long-term crash some patients feel on high-dose antibiotics is due to the fact these drugs interfere with immune activity in dose dependent fashion. With a weakened inflammatory response, a patient's symptoms may temporarily improve, but not because the pathogenic bacteria which drive disease have been eradicated. As a result, these protocols do not generate sustained immunopathology. One of the reasons why chronic Lyme disease is so contentious is that advocates for it strongly believe in the value of high-dose antibiotic therapies, any treatment which uses antibiotics at a large enough dose that the immune response is suppressed more than it is not. High-dose antibiotics are ineffective, and this is well-reflected in the published literature. The short-term improvement and long-term crash some patients feel on high-dose antibiotics is due to the fact these drugs interfere with immune activity in dose dependent fashion. With a weakened inflammatory response, a patient's symptoms may temporarily improve, but not because the pathogenic bacteria which drive disease have been eradicated. As a result, these protocols do not generate sustained immunopathology.
  
  
-=== Doxycycline ===+== Doxycycline ==
 <mainarticle> [[home:othertreatments:antibacterials:doxycycline|Doxycycline]]</article> <mainarticle> [[home:othertreatments:antibacterials:doxycycline|Doxycycline]]</article>
  
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-=== Cephlasporins including Rocephin ===+== Cephlasporins including Rocephin ==
 <mainarticle> [[home:othertreatments:antibacterials:betalactams|Beta-lactam antibiotics]]</article> <mainarticle> [[home:othertreatments:antibacterials:betalactams|Beta-lactam antibiotics]]</article>
 {{section>:home:othertreatments:antibacterials:betalactams#cephalosporins&noheader&firstseconly}} {{section>:home:othertreatments:antibacterials:betalactams#cephalosporins&noheader&firstseconly}}
  
-==== Multiple Antibiotics ====+== Multiple Antibiotics ==
  
 [[http://www.discoverymedicine.com/Jie-Feng/2019/03/persister-biofilm-microcolony-borrelia-burgdorferi-causes-severe-lyme-arthritis-in-mouse-model/|persistent disease: compared efficacy of 2-drug and 3-drug combination]] [[http://www.discoverymedicine.com/Jie-Feng/2019/03/persister-biofilm-microcolony-borrelia-burgdorferi-causes-severe-lyme-arthritis-in-mouse-model/|persistent disease: compared efficacy of 2-drug and 3-drug combination]]
  
-Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, may benefit from inquiring into the use of **3** antibiotic drugs in combination+Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of **3** antibiotic drugs in combination
  
  the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pubmed>long:    12073540}}))  the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pubmed>long:    12073540}}))
home/diseases/lyme.txt · Last modified: 09.14.2022 by 127.0.0.1
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