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home:diseases:lyme [08.12.2019] – [Antibiotic treatments] sallieqhome:diseases:lyme [09.13.2022] – external edit 127.0.0.1
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 The Marshall Protocol is an attempt to do the opposite. Rather than use immunosuppression, the MP uses antibiotics but at pulsed low doses in a way that minimizes immunosuppression. Further, antibiotics are optional. The main medication used by the MP is olmesartan, which has antimicrobial properties. The Marshall Protocol is an attempt to do the opposite. Rather than use immunosuppression, the MP uses antibiotics but at pulsed low doses in a way that minimizes immunosuppression. Further, antibiotics are optional. The main medication used by the MP is olmesartan, which has antimicrobial properties.
  
-Autoimmunity Research Foundation has been granted by the FDA [[http://autoimmunityresearch.org/orphan-clindamycin-25jul06.pdf|orphan drug status]] for clindamycin in the treatment of post-treatment Lyme disease syndrome.+Autoimmunity Research Foundation has been granted by the FDA [[https://autoimmunityresearch.org/orphan-clindamycin-25jul06.pdf|orphan drug status]] for clindamycin in the treatment of post-treatment Lyme disease syndrome.
  
 ===== Managing symptoms while on the Marshall Protocol ===== ===== Managing symptoms while on the Marshall Protocol =====
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 Lyme, //Babesia// Lyme, //Babesia//
  
-Read the [[http://bacteriality.com/2007/09/22/interview3/|interview]]+Read the [[https://bacteriality.com/2007/09/22/interview3/|interview]]
  
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 Lyme disease, irritable bowel syndrome/ulcerative colitis, radiculitis Lyme disease, irritable bowel syndrome/ulcerative colitis, radiculitis
  
-Read the [[http://bacteriality.com/2008/02/17/interview16/|interview]]+Read the [[https://bacteriality.com/2008/02/17/interview16/|interview]]
  
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 Post Treatment Lyme Disease Syndrome (PTLDS) Post Treatment Lyme Disease Syndrome (PTLDS)
  
-Read the [[http://bacteriality.com/2008/03/31/interview19/|interview]]+Read the [[https://bacteriality.com/2008/03/31/interview19/|interview]]
  
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 Lyme, myoclonus Lyme, myoclonus
  
-Read the [[http://bacteriality.com/2007/10/28/interview6/|interview]]+Read the [[https://bacteriality.com/2007/10/28/interview6/|interview]]
  
 <html></div></div></html> <html></div></div></html>
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 chronic borreliosis ("Lyme"), multiple chemical sensitivities, chronic spinal inflammation, peripheral neuropathy chronic borreliosis ("Lyme"), multiple chemical sensitivities, chronic spinal inflammation, peripheral neuropathy
  
-Read the [[http://bacteriality.com/2007/12/28/interview14/|interview]]+Read the [[https://bacteriality.com/2007/12/28/interview14/|interview]]
  
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 ===== Read more ===== ===== Read more =====
-  * According to a [[http://ngm.nationalgeographic.com/2011/11/iceman-autopsy/hall-text|2011 study]], a Neolithic mummy had //Borrelia//, suggesting that Lyme disease has been around for quite some time.  +  * According to a [[https://ngm.nationalgeographic.com/2011/11/iceman-autopsy/hall-text|2011 study]], a Neolithic mummy had //Borrelia//, suggesting that Lyme disease has been around for quite some time.  
-  * [[http://www.chicagotribune.com/health/ct-met-chronic-lyme-disease-20101207,0,5671843.story|Chronic Lyme disease: A dubious diagnosis]] – A 2010 //Chicago Tribune// article portraying Lyme advocates as unscientific. This article well represents the view of many doctors concerning Lyme advocates. +  * [[https://www.chicagotribune.com/health/ct-met-chronic-lyme-disease-20101207,0,5671843.story|Chronic Lyme disease: A dubious diagnosis]] – A 2010 //Chicago Tribune// article portraying Lyme advocates as unscientific. This article well represents the view of many doctors concerning Lyme advocates. 
-  * [[http://www.medscape.com/viewarticle/586226|Chronic Lyme Disease and the "Axis of Evil"]] – A 2009 //Future Microbiology// paper written from the perspective of ILADS and LLMDs.+  * [[https://www.medscape.com/viewarticle/586226|Chronic Lyme Disease and the "Axis of Evil"]] – A 2009 //Future Microbiology// paper written from the perspective of ILADS and LLMDs.
  
   * SPECT scans are abnormal in chronic Lyme patients – According to a 2012 study, 75% of brain SPECT scans are abnormal in patients with chronic Lyme disease.(({{pubmed>long:22889796}}))   * SPECT scans are abnormal in chronic Lyme patients – According to a 2012 study, 75% of brain SPECT scans are abnormal in patients with chronic Lyme disease.(({{pubmed>long:22889796}}))
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 The term "Lyme-literate medical doctor" or LLMD has been coined to describe physicians who acknowledge the existence of chronic Lyme disease an infectious condition and are willing to treat it with antimicrobial therapies. LLMDs generally operate outside the mainstream of medicine. A number have been brought up before medical board reviews and been the subject of patient lawsuits. The term "Lyme-literate medical doctor" or LLMD has been coined to describe physicians who acknowledge the existence of chronic Lyme disease an infectious condition and are willing to treat it with antimicrobial therapies. LLMDs generally operate outside the mainstream of medicine. A number have been brought up before medical board reviews and been the subject of patient lawsuits.
  
-The net result of this controversy is that many doctors [[http://www.ama-assn.org/amednews/2008/06/09/hlsa0609.htm|try to avoid]] having Lyme patients in their practice.+The net result of this controversy is that many doctors [[https://www.ama-assn.org/amednews/2008/06/09/hlsa0609.htm|try to avoid]] having Lyme patients in their practice.
  
  
 ==== Treatments sometimes used by those not on MP ==== ==== Treatments sometimes used by those not on MP ====
  
-  * **[[home:othertreatments:colloidal_silver|colloidal silver]]** – While colloidal silver is marketed for internal and external use as an alternative medical remedy, there is no scientific evidence of its effectiveness in vivo for any medical condition. Also, it can [[http://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html|permanently turn]] your skin silver. +  * **[[home:othertreatments:colloidal_silver|colloidal silver]]** – While colloidal silver is marketed for internal and external use as an alternative medical remedy, there is no scientific evidence of its effectiveness in vivo for any medical condition. Also, it can [[https://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html|permanently turn]] your skin silver. 
-  * **hydrogen peroxide** – Delivered intravenously. The theory is that hydrogen peroxide releases extra oxygen inside the body, killing microbes. This [[http://www.cbsnews.com/stories/2005/01/12/60II/main666489.shtml|dangerous therapy]] is based on an overly simplistic view of the body's metabolism. There are no large-scale studies proving hydrogen peroxide is effective.+  * **hydrogen peroxide** – Delivered intravenously. The theory is that hydrogen peroxide releases extra oxygen inside the body, killing microbes. This [[https://www.cbsnews.com/stories/2005/01/12/60II/main666489.shtml|dangerous therapy]] is based on an overly simplistic view of the body's metabolism. There are no large-scale studies proving hydrogen peroxide is effective.
   * **[[home:othertreatments:rife|Rife]]** – There is no scientific evidence that the use of a Rife device has the intended effect on infectious bacteria. Instead, most patients using Rife are likely administering themselves nothing more than an expensive placebo.   * **[[home:othertreatments:rife|Rife]]** – There is no scientific evidence that the use of a Rife device has the intended effect on infectious bacteria. Instead, most patients using Rife are likely administering themselves nothing more than an expensive placebo.
  
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 Not suitable for children (({{pubmed>long:6470872}})), (({{pubmed>long:9093309}})) Not suitable for children (({{pubmed>long:6470872}})), (({{pubmed>long:9093309}}))
  
-May be for adolescents (({{pubmed>long:27613346}}))+may be possible for some adolescents (({{pubmed>long:27613346}}))
  
 ===   === ===   ===
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 == Multiple ABx == == Multiple ABx ==
  
-[[http://www.discoverymedicine.com/Jie-Feng/2019/03/persister-biofilm-microcolony-borrelia-burgdorferi-causes-severe-lyme-arthritis-in-mouse-model/|persistent disease: compared efficacy of 2-drug and 3-drug combination]]+[[https://www.discoverymedicine.com/Jie-Feng/2019/03/persister-biofilm-microcolony-borrelia-burgdorferi-causes-severe-lyme-arthritis-in-mouse-model/|persistent disease: compared efficacy of 2-drug and 3-drug combination]]
  
-Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of **3** antibiotic drugs in combination, as single drugs and 2-drug combinations appear to be ineffeccive with some PTLDS Borrelia biofilm.+Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of **3** antibiotic drugs in combination, as single drugs and 2-drug combinations appear to be ineffective with some PTLDS Borrelia biofilm.
  
  the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pubmed>long:    12073540}}))  the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pubmed>long:    12073540}}))
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 //broken link removed// //broken link removed//
-Lyme patients [[http://www.topix.net/forum/health/lyme-disease/TLR5VKTCM71F9PEAP|commiserate]] with one another over feeling worse after taking vitamin D. +Lyme patients [[https://www.topix.net/forum/health/lyme-disease/TLR5VKTCM71F9PEAP|commiserate]] with one another over feeling worse after taking vitamin D. 
    
  
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 <blockquote> <blockquote>
-Antibodies linked to long-term Lyme symptoms: Some patients with Lyme disease still show symptoms long after the... http://bit.ly/qbAFjv+Antibodies linked to long-term Lyme symptoms: Some patients with Lyme disease still show symptoms long after the... https://bit.ly/qbAFjv
  
 From: Frenchie From: Frenchie
 Date: 2011-08-09 07:08:55 Date: 2011-08-09 07:08:55
-Reply: http://www.marshallprotocol.com/reply.php?topic_id=13346+Reply: https://www.marshallprotocol.com/reply.php?topic_id=13346
  
 Now Armin Alaedini at Weill Cornell Medical College in New York and  his colleagues have found that patients diagnosed with post-Lyme disease  syndrome have antibodies that suggest they carried the infection for an  unusually long time. The finding, published in  Clinical Immunology1, might help the syndrome to be better understood, diagnosed and treated. Now Armin Alaedini at Weill Cornell Medical College in New York and  his colleagues have found that patients diagnosed with post-Lyme disease  syndrome have antibodies that suggest they carried the infection for an  unusually long time. The finding, published in  Clinical Immunology1, might help the syndrome to be better understood, diagnosed and treated.
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 This finding suggests that patients with chronic symptoms have  experienced a prolonged infection, caused by microbes that have evaded  the immune system by varying the epitopes they carry. As a result of  these variations, the body makes new antibodies targeting the modified  protein. The longer the microbe manages to keep changing, the more  diverse its host's antibodies become. This finding suggests that patients with chronic symptoms have  experienced a prolonged infection, caused by microbes that have evaded  the immune system by varying the epitopes they carry. As a result of  these variations, the body makes new antibodies targeting the modified  protein. The longer the microbe manages to keep changing, the more  diverse its host's antibodies become.
  
-http://www.nature.com/news/2011/110805/full/news.2011.463.html#B1+https://www.nature.com/news/2011/110805/full/news.2011.463.html#B1
  
  
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 From: Dr Trevor Marshall From: Dr Trevor Marshall
 Date: 2011-08-09 07:16:27 Date: 2011-08-09 07:16:27
-Reply: http://www.marshallprotocol.com/reply.php?topic_id=13346+Reply: https://www.marshallprotocol.com/reply.php?topic_id=13346
  
 The group at Weill Cornell did not consider the possibility that their testing procedures might be confused by the thousands of other species present along with the Borrelia. I read this report, and although not junk science, it is of little practical use until their procedures become more precise, IMO. They really don't have much of a clue. The group at Weill Cornell did not consider the possibility that their testing procedures might be confused by the thousands of other species present along with the Borrelia. I read this report, and although not junk science, it is of little practical use until their procedures become more precise, IMO. They really don't have much of a clue.
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 |**Timing**  |Occurs days to weeks after the bite of an infected tick.   |By some, thought to occur months to years after initial infection.  | |**Timing**  |Occurs days to weeks after the bite of an infected tick.   |By some, thought to occur months to years after initial infection.  |
 |**Conventional explanation for cause**  |A tick-borne disease, caused by at least three species of bacteria belonging to the genus //Borrelia//    |Variable and highly controversial. Some argue chronic Lyme is [[#psychosomatic_explanations_for_disease|psychosomatic]].         | |**Conventional explanation for cause**  |A tick-borne disease, caused by at least three species of bacteria belonging to the genus //Borrelia//    |Variable and highly controversial. Some argue chronic Lyme is [[#psychosomatic_explanations_for_disease|psychosomatic]].         |
-|**Laboratory tests**   |A two-tiered protocol is recommended by the CDC for evaluation of the presence of //Borrelia//: the sensitive ELISA test is performed first, and if it is positive or equivocal, then the more specific Western blot is run.   |Variety of (expensive) tests, none of which are widely accepted by the vast majority of mainstream researchers or physicians. The CDC and FDA [[http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5405a6.htm|issued a warning]] about “commercial laboratories that conduct testing for Lyme disease by using assays whose accuracy and clinical usefulness have not been adequately established.       |+|**Laboratory tests**   |A two-tiered protocol is recommended by the CDC for evaluation of the presence of //Borrelia//: the sensitive ELISA test is performed first, and if it is positive or equivocal, then the more specific Western blot is run.   |Variety of (expensive) tests, none of which are widely accepted by the vast majority of mainstream researchers or physicians. The CDC and FDA [[https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5405a6.htm|issued a warning]] about “commercial laboratories that conduct testing for Lyme disease by using assays whose accuracy and clinical usefulness have not been adequately established.       |
 |**Diagnosis**   |Diagnosed clinically based on symptoms, objective physical findings – such as erythema migrans (bulls eye rash), facial palsy or arthritis – or a history of possible exposure to infected ticks, as well as blood tests. Living in a tick-endemic area increases the likelihood of a Lyme diagnosis.    |For those with a negative test for //Borrelia//, getting a diagnosis of chronic Lyme depends largely on whether the doctor is "Lyme literate", that is if he/she even acknowledges the existence of chronic Lyme.  | |**Diagnosis**   |Diagnosed clinically based on symptoms, objective physical findings – such as erythema migrans (bulls eye rash), facial palsy or arthritis – or a history of possible exposure to infected ticks, as well as blood tests. Living in a tick-endemic area increases the likelihood of a Lyme diagnosis.    |For those with a negative test for //Borrelia//, getting a diagnosis of chronic Lyme depends largely on whether the doctor is "Lyme literate", that is if he/she even acknowledges the existence of chronic Lyme.  |
 |**Controversy over legitimacy of diagnosis**    |Some disagreement over validity of tests, but controversy is relatively minimal.       |Diagnosis is most controversially applied to patients with nonspecific symptoms (e.g., fatigue), who show no objective evidence they have been infected with Lyme disease in the past, since the standard diagnostic tests for infection are negative. Most physicians [[#chronic_controversy_over_chronic_lyme_disease|do not accept]] chronic Lyme as a legitimate diagnosis.       | |**Controversy over legitimacy of diagnosis**    |Some disagreement over validity of tests, but controversy is relatively minimal.       |Diagnosis is most controversially applied to patients with nonspecific symptoms (e.g., fatigue), who show no objective evidence they have been infected with Lyme disease in the past, since the standard diagnostic tests for infection are negative. Most physicians [[#chronic_controversy_over_chronic_lyme_disease|do not accept]] chronic Lyme as a legitimate diagnosis.       |
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 <blockquote>Oct. 7, 2005: The problem is actually a lot more complex than it seems. The genome of Borrelia has about 40% of its genes on mobile plasmids, and not on the primary chromosome. So (arguably) there could be hundreds of different versions of B.burgdorferi out there. <blockquote>Oct. 7, 2005: The problem is actually a lot more complex than it seems. The genome of Borrelia has about 40% of its genes on mobile plasmids, and not on the primary chromosome. So (arguably) there could be hundreds of different versions of B.burgdorferi out there.
  
-If you look at the master genome list at [[http://www.ncbi.nlm.nih.gov/genomes/lproks.cgi|820 Complete Microbial Genomes]] you will find only two Borrelia species fully sequenced. One was sequenced by TIGR and one from Germany. Look at the sizes - 1.52 vs 0.99. This is because the Germans are only reporting the Chromosome and 2 plasmids, while TIGR is reporting chromosome and 21 plasmids.+If you look at the master genome list at [[https://www.ncbi.nlm.nih.gov/genomes/lproks.cgi|820 Complete Microbial Genomes]] you will find only two Borrelia species fully sequenced. One was sequenced by TIGR and one from Germany. Look at the sizes - 1.52 vs 0.99. This is because the Germans are only reporting the Chromosome and 2 plasmids, while TIGR is reporting chromosome and 21 plasmids.
  
 Unfortunately the Borrelia genome has proven too complex for many of our institutions to fully assimilate, and this is an excellent example. Both groups are correct, but they are looking at the species in different ways. Unfortunately the Borrelia genome has proven too complex for many of our institutions to fully assimilate, and this is an excellent example. Both groups are correct, but they are looking at the species in different ways.
  
 A similar situation exists within the Mycoplasma species. Look for example, at this species comparison: A similar situation exists within the Mycoplasma species. Look for example, at this species comparison:
-[[http://www.zmbh.uni-heidelberg.de/M_pneumoniae/genome/MP_MG_Comp.GIF|Gene map of the Mycoplasma pneumoniae genome]]+[[https://www.zmbh.uni-heidelberg.de/M_pneumoniae/genome/MP_MG_Comp.GIF|Gene map of the Mycoplasma pneumoniae genome]]
  
 The rapid pace of advance in science's knowledge of the genome has left 99.9% of our infectious diseases specialists behind. It will take a new generation to come along who can understand the new genomic tools. The rapid pace of advance in science's knowledge of the genome has left 99.9% of our infectious diseases specialists behind. It will take a new generation to come along who can understand the new genomic tools.
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 ==== Treatments sometimes used by those not on MP ==== ==== Treatments sometimes used by those not on MP ====
  
-  * **[[home:othertreatments:colloidal_silver|colloidal silver]]** – While colloidal silver is marketed for internal and external use as an alternative medical remedy, there is no scientific evidence of its effectiveness in vivo for any medical condition. Also, it can [[http://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html|permanently turn]] your skin silver. +  * **[[home:othertreatments:colloidal_silver|colloidal silver]]** – While colloidal silver is marketed for internal and external use as an alternative medical remedy, there is no scientific evidence of its effectiveness in vivo for any medical condition. Also, it can [[https://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html|permanently turn]] your skin silver. 
-  * **hydrogen peroxide** – Delivered intravenously. The theory is that hydrogen peroxide releases extra oxygen inside the body, killing microbes. This [[http://www.cbsnews.com/stories/2005/01/12/60II/main666489.shtml|dangerous therapy]] is based on an overly simplistic view of the body's metabolism. There are no large-scale studies proving hydrogen peroxide is effective.+  * **hydrogen peroxide** – Delivered intravenously. The theory is that hydrogen peroxide releases extra oxygen inside the body, killing microbes. This [[https://www.cbsnews.com/stories/2005/01/12/60II/main666489.shtml|dangerous therapy]] is based on an overly simplistic view of the body's metabolism. There are no large-scale studies proving hydrogen peroxide is effective.
   * **[[home:othertreatments:rife|Rife]]** – There is no scientific evidence that the use of a Rife device has the intended effect on infectious bacteria. Instead, most patients using Rife are likely administering themselves nothing more than an expensive placebo.   * **[[home:othertreatments:rife|Rife]]** – There is no scientific evidence that the use of a Rife device has the intended effect on infectious bacteria. Instead, most patients using Rife are likely administering themselves nothing more than an expensive placebo.
  
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 == Multiple Antibiotics == == Multiple Antibiotics ==
  
-[[http://www.discoverymedicine.com/Jie-Feng/2019/03/persister-biofilm-microcolony-borrelia-burgdorferi-causes-severe-lyme-arthritis-in-mouse-model/|persistent disease: compared efficacy of 2-drug and 3-drug combination]]+[[https://www.discoverymedicine.com/Jie-Feng/2019/03/persister-biofilm-microcolony-borrelia-burgdorferi-causes-severe-lyme-arthritis-in-mouse-model/|persistent disease: compared efficacy of 2-drug and 3-drug combination]]
  
 Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of **3** antibiotic drugs in combination Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of **3** antibiotic drugs in combination
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 ===== References ===== ===== References =====
 +
home/diseases/lyme.txt · Last modified: 09.14.2022 by 127.0.0.1
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