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home:diseases:ocd [02.26.2017] – [OCD in experimental animals] rarranged and added headings sallieqhome:diseases:ocd [02.17.2019] – [Obsessive Compulsive Disorder and experience of MP patients] sallieq
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-===== Obsessive Compulsive Disorder and experience of MP patients =====+===== Experience of Patients =====
  
  
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 Janet (kilt) Janet (kilt)
  
-MPers report OCD symptom resolution+===== MPers report OCD symptom resolution ===== 
  
 My 15 yr.old daughter who also like myself, has neuro-lyme disease, was significantly affected with OCD, incapacitated as a matter of fact. Treatment with minocycline has been a godsend for her, she is doing 80% better, and we expect the improvement to continue as she introduces more/differing abx to kill the occult bacteria. It was suspected that she contracted PANDAS (pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection) the year after becoming ill with Borreliosis, and this is what led to the increasing significant neuro-psychological difficulties she began having, in addition to her Borrelia symptoms. My 15 yr.old daughter who also like myself, has neuro-lyme disease, was significantly affected with OCD, incapacitated as a matter of fact. Treatment with minocycline has been a godsend for her, she is doing 80% better, and we expect the improvement to continue as she introduces more/differing abx to kill the occult bacteria. It was suspected that she contracted PANDAS (pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection) the year after becoming ill with Borreliosis, and this is what led to the increasing significant neuro-psychological difficulties she began having, in addition to her Borrelia symptoms.
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 ====== OCD in experimental animals ====== ====== OCD in experimental animals ======
  
-http://www.sciencedaily.com/releases/2009/08/090811143538.htm +Streptococcal infections can induce obsessive-compulsive and tic disorders. In children, this syndrome, frequently associated with disturbances in attention, learning and mood, has been designated pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Autoantibodies recognizing central nervous system (CNS) epitopes are found in sera of most PANDAS subjects, but may not be unique to this neuropsychiatric subset.  
-Yaddanapudi, K., M. Hornig, et al. (2009). "Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection." Mol Psychiatry. (({{pubmed>long:19668249}}))+ 
 +In support of a humoral immune mechanism, clinical improvement often follows plasmapheresis or intravenous immunoglobulin. We recently described a PANDAS mouse model wherein repetitive behaviors correlate with peripheral anti-CNS antibodies and immune deposits in brain following streptococcal immunization. These antibodies are directed against group A beta-hemolytic streptococcus matrix (M) protein and cross-react with molecular targets complement C4 protein and alpha-2-macroglobulin in brain. Here we show additional deficits in motor coordination, learning/memory and social interaction in PANDAS mice, replicating more complex aspects of human disease. 
  
-Streptococcal infections can induce obsessive-compulsive and tic disorders. In children, this syndrome, frequently associated with disturbances in attention, learning and mood, has been designated pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Autoantibodies recognizing central nervous system (CNS) epitopes are found in sera of most PANDAS subjects, but may not be unique to this neuropsychiatric subset. In support of a humoral immune mechanism, clinical improvement often follows plasmapheresis or intravenous immunoglobulin. We recently described a PANDAS mouse model wherein repetitive behaviors correlate with peripheral anti-CNS antibodies and immune deposits in brain following streptococcal immunization. These antibodies are directed against group A beta-hemolytic streptococcus matrix (M) protein and cross-react with molecular targets complement C4 protein and alpha-2-macroglobulin in brain. Here we show additional deficits in motor coordination, learning/memory and social interaction in PANDAS mice, replicating more complex aspects of human disease. Furthermore, we demonstrate for the first time that humoral immunity is necessary and sufficient to induce the syndrome through experiments wherein naive mice are transfused with immunoglobulin G (IgG) from PANDAS mice. Depletion of IgG from donor sera abrogates behavior changes. These functional disturbances link to the autoimmunity-related IgG1 subclass but are not attributable to differences in cytokine profiles. The mode of disrupting blood-brain barrier integrity differentially affects the ultimate CNS distribution of these antibodies and is shown to be an additional important determinant of neuropsychiatric outcomes. This work provides insights into PANDAS pathogenesis and may lead to new strategies for identification and treatment of children at risk for autoimmune brain disorders.Molecular Psychiatry advance online publication, 11 August 2009; doi:10.1038/mp.2009.77.+Furthermore, we demonstrate for the first time that humoral immunity is necessary and sufficient to induce the syndrome through experiments wherein naive mice are transfused with immunoglobulin G (IgG) from PANDAS mice. Depletion of IgG from donor sera abrogates behavior changes. These functional disturbances link to the autoimmunity-related IgG1 subclass but are not attributable to differences in cytokine profiles. The mode of disrupting blood-brain barrier integrity differentially affects the ultimate CNS distribution of these antibodies and is shown to be an additional important determinant of neuropsychiatric outcomes. This work provides insights into PANDAS pathogenesis and may lead to new strategies for identification and treatment of children at risk for autoimmune brain disorders. (({{pubmed>long:19668249}}))
  
 See also Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System.   (({{pubmed>long:20072118}}))    See also Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System.   (({{pubmed>long:20072118}}))   
-contains link to free article  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055356/ 
  
  
-{{tag>diseases neurological}}+{{tag>disease neurological arrange}}
  
  
-<note>Dear MPKB Reader: You have arrived at one of the articles that has not yet completed the development and review process in the knowledge base. Some of the content here may be helpful, but please know that this page is not complete. There are about 400 articles in the KB, and this is one we are still working on. Thanks for your patience.</note> 
  
 ===== Notes and comments ===== ===== Notes and comments =====
home/diseases/ocd.txt · Last modified: 09.14.2022 by 127.0.0.1
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