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home:diseases:ocd [02.17.2019] – [OCD in experimental animals] sallieq | home:diseases:ocd [02.17.2019] – [Experience of Patients] sallieq | ||
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====== Obsessive compulsive disorder (OCD) ====== | ====== Obsessive compulsive disorder (OCD) ====== | ||
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===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
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- | J Pediatr. 2012 Feb; | + | __Clinical factors__: |
- | Clinical factors associated with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. | + | |
- | Murphy TK, Storch EA, Lewin AB, Edge PJ, Goodman WK. | + | |
- | Source | + | |
- | Department of Pediatrics, University of South Florida, St. Petersburg, FL 33701, USA. tmurphy@health.usf.edu | + | |
- | Abstract | + | |
- | OBJECTIVE: | + | |
- | To explore associated clinical factors in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). | + | |
- | STUDY DESIGN: | + | |
Children with tics, obsessive-compulsive disorder, or both (n=109) were examined with personal and family history, diagnostic interview, physical examination, | Children with tics, obsessive-compulsive disorder, or both (n=109) were examined with personal and family history, diagnostic interview, physical examination, | ||
- | RESULTS: | + | |
Significant group differences were found on several variables, such that children in whom PANDAS (versus without PANDAS) were more likely to have had dramatic onset, definite remissions, remission of neuropsychiatric symptoms during antibiotic therapy, a history of tonsillectomies/ | Significant group differences were found on several variables, such that children in whom PANDAS (versus without PANDAS) were more likely to have had dramatic onset, definite remissions, remission of neuropsychiatric symptoms during antibiotic therapy, a history of tonsillectomies/ | ||
- | CONCLUSION: | + | |
- | The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/ | + | |
- | Copyright © 2012 Mosby, Inc. All rights reserved. | + | The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/ |
- | J Child Adolesc Psychopharmacol. 2011 Apr; | + | __Identical siblings__ |
- | Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus in identical siblings. | + | Termed pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), these cases of childhood-onset obsessive compulsive disorder and tic disorders resemble the presentation of Sydenham chorea, in that they have an acute onset following a group A beta-hemolytic streptococcal infection (group A Streptococcus), |
- | Lewin AB, Storch EA, Murphy TK. | + | |
- | Source | + | This report provides phenotypic descriptions of three youth with PANDAS as well as their genetically identical siblings (in two cases of twins and one case of triplets). These cases highlight the potential for environmental influences for discordant presentations in genetically identical siblings. |
- | Rothman Center for Neuropsychiatry, | + | |
- | Abstract | + | Despite identical genetics, presentations showed marked variation across siblings (from a full PANDAS presentation to asymptomatic). Further research into environmentally driven influences such as postinfectious molecular mimicry and epigenetic factors that may influence the manifestation of these pediatric neuropsychiatric disorders will promote our understanding of their prevention and treatment. |
- | Termed pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), these cases of childhood-onset obsessive compulsive disorder and tic disorders resemble the presentation of Sydenham chorea, in that they have an acute onset following a group A beta-hemolytic streptococcal infection (group A Streptococcus), | + | |
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- | ===== Obsessive Compulsive Disorder and experience | + | |
+ | ===== Experience | ||
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Interview with Julia Grier - sarcoidosis, | Interview with Julia Grier - sarcoidosis, | ||
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- | Phobias | + | |
+ | __Phobias | ||
I think you've spoken to my twin sister Jean (also on the MP). I have been on the MP now for about 4 months. | I think you've spoken to my twin sister Jean (also on the MP). I have been on the MP now for about 4 months. | ||
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Janet (kilt) | Janet (kilt) | ||
- | MPers report OCD symptom resolution | + | ===== MPers report OCD symptom resolution |
My 15 yr.old daughter who also like myself, has neuro-lyme disease, was significantly affected with OCD, incapacitated as a matter of fact. Treatment with minocycline has been a godsend for her, she is doing 80% better, and we expect the improvement to continue as she introduces more/ | My 15 yr.old daughter who also like myself, has neuro-lyme disease, was significantly affected with OCD, incapacitated as a matter of fact. Treatment with minocycline has been a godsend for her, she is doing 80% better, and we expect the improvement to continue as she introduces more/ | ||
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====== OCD in experimental animals ====== | ====== OCD in experimental animals ====== | ||
- | http://www.sciencedaily.com/ | + | Streptococcal infections can induce obsessive-compulsive and tic disorders. In children, this syndrome, frequently associated with disturbances in attention, learning and mood, has been designated |
- | Yaddanapudi, K., M. Hornig, et al. (2009). " | + | |
+ | In support of a humoral immune mechanism, clinical improvement often follows plasmapheresis or intravenous immunoglobulin. We recently described a PANDAS mouse model wherein repetitive behaviors correlate with peripheral anti-CNS antibodies and immune deposits in brain following streptococcal immunization. These antibodies are directed against group A beta-hemolytic streptococcus matrix | ||
- | Streptococcal infections can induce obsessive-compulsive and tic disorders. In children, this syndrome, frequently associated with disturbances in attention, learning and mood, has been designated pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Autoantibodies recognizing central nervous system (CNS) epitopes are found in sera of most PANDAS subjects, but may not be unique to this neuropsychiatric subset. In support of a humoral immune mechanism, clinical improvement often follows plasmapheresis or intravenous immunoglobulin. We recently described a PANDAS mouse model wherein repetitive behaviors correlate with peripheral anti-CNS antibodies and immune deposits in brain following streptococcal immunization. These antibodies are directed against group A beta-hemolytic streptococcus matrix (M) protein and cross-react with molecular targets complement C4 protein and alpha-2-macroglobulin in brain. Here we show additional deficits in motor coordination, | + | Furthermore, |
See also Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System. | See also Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System. | ||
- | contains link to free article | ||
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===== Notes and comments ===== | ===== Notes and comments ===== |