Differences

This shows you the differences between two versions of the page.

--- home:diseases:ocd [02.17.2019] – [Obsessive Compulsive Disorder and experience of MP patients] sallieq
+++ home:diseases:ocd [02.17.2019] – sallieq
@@ Line 1: / Line 1: @@
-<IncompleteNotice>
 ====== Obsessive compulsive disorder (OCD) ======
 ===== Evidence of infectious cause =====
-<blockquote>
-J Pediatr. 2012 Feb;160(2):314-9. Epub 2011 Aug 25.
+__Clinical factors__:
-Clinical factors associated with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.
-Murphy TK, Storch EA, Lewin AB, Edge PJ, Goodman WK.
-Source
-Department of Pediatrics, University of South Florida, St. Petersburg, FL 33701, USA. tmurphy@health.usf.edu
-Abstract
-OBJECTIVE:
-To explore associated clinical factors in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).
-STUDY DESIGN:
 Children with tics, obsessive-compulsive disorder, or both (n=109) were examined with personal and family history, diagnostic interview, physical examination, medical record review, and measurement of baseline levels of streptococcal antibodies.
-RESULTS:
 Significant group differences were found on several variables, such that children in whom PANDAS (versus without PANDAS) were more likely to have had dramatic onset, definite remissions, remission of neuropsychiatric symptoms during antibiotic therapy, a history of tonsillectomies/adenoidectomies, evidence of group A streptococcal infection, and clumsiness.
-CONCLUSION:
-The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/tics.
-Copyright © 2012 Mosby, Inc. All rights reserved.  (({{pubmed>long:21868033}}))
+The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/tics  (({{pubmed>long:21868033}}))
-J Child Adolesc Psychopharmacol. 2011 Apr;21(2):177-82. Epub 2011 Apr 12.
+__Identical siblings__
-Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus in identical siblings.
+Termed pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), these cases of childhood-onset obsessive compulsive disorder and tic disorders resemble the presentation of Sydenham chorea, in that they have an acute onset following a group A beta-hemolytic streptococcal infection (group A Streptococcus), with accompanying neurological signs, and an episodic or sawtooth course. Familial associations of this subgroup of patients remain understudied.
-Lewin AB, Storch EA, Murphy TK.
-Source
+This report provides phenotypic descriptions of three youth with PANDAS as well as their genetically identical siblings (in two cases of twins and one case of triplets). These cases highlight the potential for environmental influences for discordant presentations in genetically identical siblings.
-Rothman Center for Neuropsychiatry, Department of Pediatrics, University of South Florida College of Medicine, St. Petersburg, Florida 33701, USA. alewin@health.usf.edu
-Abstract
+Despite identical genetics, presentations showed marked variation across siblings (from a full PANDAS presentation to asymptomatic). Further research into environmentally driven influences such as postinfectious molecular mimicry and epigenetic factors that may influence the manifestation of these pediatric neuropsychiatric disorders will promote our understanding of their prevention and treatment.   (({{pubmed>long:21486169}}))
-Termed pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), these cases of childhood-onset obsessive compulsive disorder and tic disorders resemble the presentation of Sydenham chorea, in that they have an acute onset following a group A beta-hemolytic streptococcal infection (group A Streptococcus), with accompanying neurological signs, and an episodic or sawtooth course. Familial associations of this subgroup of patients remain understudied. This report provides phenotypic descriptions of three youth with PANDAS as well as their genetically identical siblings (in two cases of twins and one case of triplets). These cases highlight the potential for environmental influences for discordant presentations in genetically identical siblings. Despite identical genetics, presentations showed marked variation across siblings (from a full PANDAS presentation to asymptomatic). Further research into environmentally driven influences such as postinfectious molecular mimicry and epigenetic factors that may influence the manifestation of these pediatric neuropsychiatric disorders will promote our understanding of their prevention and treatment.   (({{pubmed>long:21486169}}))
-</blockquote>

home/diseases/ocd.txt · Last modified: 09.14.2022 by 127.0.0.1