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home:diseases:ocd [02.17.2019] – [Obsessive Compulsive Disorder and experience of MP patients] sallieq | home:diseases:ocd [09.14.2022] (current) – external edit 127.0.0.1 | ||
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====== Obsessive compulsive disorder (OCD) ====== | ====== Obsessive compulsive disorder (OCD) ====== | ||
+ | ===== Evidence of infectious cause ===== | ||
+ | __Clinical factors__: | ||
+ | Children with tics, obsessive-compulsive disorder, or both (n=109) were examined with personal and family history, diagnostic interview, physical examination, | ||
- | ===== Evidence of infectious cause ===== | ||
- | < | + | Significant group differences were found on several variables, such that children in whom PANDAS (versus without PANDAS) were more likely to have had dramatic onset, definite remissions, remission of neuropsychiatric symptoms during antibiotic therapy, a history of tonsillectomies/ |
- | J Pediatr. 2012 Feb; | + | |
- | Clinical factors associated with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. | + | The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/ |
- | Murphy TK, Storch EA, Lewin AB, Edge PJ, Goodman WK. | + | |
- | Source | + | |
- | Department of Pediatrics, University of South Florida, St. Petersburg, FL 33701, USA. tmurphy@health.usf.edu | + | |
- | Abstract | + | |
- | OBJECTIVE: | + | |
- | To explore associated clinical factors in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). | + | |
- | STUDY DESIGN: | + | |
- | Children with tics, obsessive-compulsive disorder, or both (n=109) were examined with personal and family history, diagnostic interview, physical examination, | + | |
- | RESULTS: | + | |
- | Significant group differences were found on several variables, such that children in whom PANDAS (versus without PANDAS) were more likely to have had dramatic onset, definite remissions, remission of neuropsychiatric symptoms during antibiotic therapy, a history of tonsillectomies/ | + | |
- | CONCLUSION: | + | |
- | The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/ | + | |
- | Copyright © 2012 Mosby, Inc. All rights reserved. | + | |
- | J Child Adolesc Psychopharmacol. 2011 Apr; | + | __Identical siblings__ |
- | Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus in identical siblings. | + | Termed pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), these cases of childhood-onset obsessive compulsive disorder and tic disorders resemble the presentation of Sydenham chorea, in that they have an acute onset following a group A beta-hemolytic streptococcal infection (group A Streptococcus), |
- | Lewin AB, Storch EA, Murphy TK. | + | |
- | Source | + | This report provides phenotypic descriptions of three youth with PANDAS as well as their genetically identical siblings (in two cases of twins and one case of triplets). These cases highlight the potential for environmental influences for discordant presentations in genetically identical siblings. |
- | Rothman Center for Neuropsychiatry, | + | |
- | Abstract | + | Despite identical genetics, presentations showed marked variation across siblings (from a full PANDAS presentation to asymptomatic). Further research into environmentally driven influences such as postinfectious molecular mimicry and epigenetic factors that may influence the manifestation of these pediatric neuropsychiatric disorders will promote our understanding of their prevention and treatment. |
- | Termed pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), these cases of childhood-onset obsessive compulsive disorder and tic disorders resemble the presentation of Sydenham chorea, in that they have an acute onset following a group A beta-hemolytic streptococcal infection (group A Streptococcus), | + | |
- | </ | + | |
===== Experience of Patients ===== | ===== Experience of Patients ===== | ||
+ | |||
+ | < | ||
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Interview with Julia Grier - sarcoidosis, | Interview with Julia Grier - sarcoidosis, | ||
- | ================================ | ||
- | Phobias | + | |
+ | __Phobias | ||
I think you've spoken to my twin sister Jean (also on the MP). I have been on the MP now for about 4 months. | I think you've spoken to my twin sister Jean (also on the MP). I have been on the MP now for about 4 months. | ||
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In support of a humoral immune mechanism, clinical improvement often follows plasmapheresis or intravenous immunoglobulin. We recently described a PANDAS mouse model wherein repetitive behaviors correlate with peripheral anti-CNS antibodies and immune deposits in brain following streptococcal immunization. These antibodies are directed against group A beta-hemolytic streptococcus matrix (M) protein and cross-react with molecular targets complement C4 protein and alpha-2-macroglobulin in brain. Here we show additional deficits in motor coordination, | In support of a humoral immune mechanism, clinical improvement often follows plasmapheresis or intravenous immunoglobulin. We recently described a PANDAS mouse model wherein repetitive behaviors correlate with peripheral anti-CNS antibodies and immune deposits in brain following streptococcal immunization. These antibodies are directed against group A beta-hemolytic streptococcus matrix (M) protein and cross-react with molecular targets complement C4 protein and alpha-2-macroglobulin in brain. Here we show additional deficits in motor coordination, | ||
- | Furthermore, | + | Furthermore, |
- | See also Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System. | + | See also Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System. |
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+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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- | * **Obsessive compulsive disorder and childhood infections like strep** – A 2010 team of researchers developed a new animal model to show how exposure to strep affects the brain and leads to a number of physical and mental ailments. According to one of the collaborators, | + | * **Obsessive compulsive disorder and childhood infections like strep** – A 2010 team of researchers developed a new animal model to show how exposure to strep affects the brain and leads to a number of physical and mental ailments. According to one of the collaborators, |
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* legacy content | * legacy content | ||
- | * http:// | + | * https:// |
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School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel. | School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel. | ||
Abstract | Abstract | ||
- | Group A streptococcal (GAS) infections and autoimmunity are associated with the onset of a spectrum of neuropsychiatric disorders in children, with the prototypical disorder being Sydenham chorea (SC). Our aim was to develop an animal model that resembled the behavioral, pharmacological, | + | Group A streptococcal (GAS) infections and autoimmunity are associated with the onset of a spectrum of neuropsychiatric disorders in children, with the prototypical disorder being Sydenham chorea (SC). Our aim was to develop an animal model that resembled the behavioral, pharmacological, |
</ | </ | ||
- | ===== References ===== | + | ===== References =====</ |