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home:diseases:osteoporosis_osteopenia [12.19.2018] – [Vitamin D supplementation] sallieqhome:diseases:osteoporosis_osteopenia [02.18.2019] – [Other treatments] sallieq
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 ===== Other treatments ===== ===== Other treatments =====
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 +Calcitonin    (({{pubmed>long:    30725954}}))
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 +<blockquote>Salmon calcitonin (after this referred to as “calcitonin”) is an analog of human calcitonin used in the treatment of postmenopausal osteoporosis, Paget disease of bone, and hypercalcemia. Its clinical importance derives from its ability to inhibit osteoclasts and increase renal excretion of calcium. 
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 +Through these processes, bone matrix resorption and serum calcium are both decreased.
 +</blockquote>
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 ==== Calcium supplementation ==== ==== Calcium supplementation ====
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 <blockquote>Calcium supplements have been widely used by older men and women. However, in little more than a decade, authoritative recommendations have changed from encouraging the widespread use of calcium supplements to stating that they should not be used for primary prevention of fractures. This substantial shift in recommendations has occurred as a result of accumulated evidence of marginal antifracture efficacy, and important adverse effects from large randomized controlled trials of calcium or coadministered calcium and vitamin D supplements. In this review, we discuss this evidence, with a particular focus on increased cardiovascular risk with calcium supplements, which we first described 5 years ago. Calcium supplements with or without vitamin D marginally reduce total fractures but do not prevent hip fractures in community-dwelling individuals. They also cause kidney stones, acute gastrointestinal events, and increase the risk of myocardial infarction and stroke. //Bolland MJ, Grey A, and Reid IR// 2013  (({{pubmed>long:25114781}}))</blockquote> <blockquote>Calcium supplements have been widely used by older men and women. However, in little more than a decade, authoritative recommendations have changed from encouraging the widespread use of calcium supplements to stating that they should not be used for primary prevention of fractures. This substantial shift in recommendations has occurred as a result of accumulated evidence of marginal antifracture efficacy, and important adverse effects from large randomized controlled trials of calcium or coadministered calcium and vitamin D supplements. In this review, we discuss this evidence, with a particular focus on increased cardiovascular risk with calcium supplements, which we first described 5 years ago. Calcium supplements with or without vitamin D marginally reduce total fractures but do not prevent hip fractures in community-dwelling individuals. They also cause kidney stones, acute gastrointestinal events, and increase the risk of myocardial infarction and stroke. //Bolland MJ, Grey A, and Reid IR// 2013  (({{pubmed>long:25114781}}))</blockquote>
  
-<blockquote>Web of industry, advocacy, and academia in the management of osteoporosis   http://www.bmj.com/content/351/bmj.h3170+<blockquote>Web of industry, advocacy, and academia in the management of osteoporosis   [[http://www.bmj.com/content/351/bmj.h3170| BMJ 2015;351:h3170 ]]
  
 "Calcium and vitamin D supplementation continue to be recommended to prevent and treat osteoporosis despite evidence of lack of benefit, say Andrew Grey and Mark Bolland. They examine why change is difficult and call for advocacy organisations, academics, and specialist societies to abandon industry ties" </blockquote> "Calcium and vitamin D supplementation continue to be recommended to prevent and treat osteoporosis despite evidence of lack of benefit, say Andrew Grey and Mark Bolland. They examine why change is difficult and call for advocacy organisations, academics, and specialist societies to abandon industry ties" </blockquote>
home/diseases/osteoporosis_osteopenia.txt · Last modified: 09.14.2022 by 127.0.0.1
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