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home:diseases:parkinsons [04.09.2017] – [Neuropatholgy] sallieq | home:diseases:parkinsons [01.10.2019] – [Neuropathology] sallieq | ||
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Clustering of Parkinson disease: shared cause or coincidence? | Clustering of Parkinson disease: shared cause or coincidence? | ||
- | Kumar A, Calne SM, Schulzer M, Mak E, Wszolek Z, Van Netten C, Tsui JK, Stoessl AJ, Calne DB. | + | BACKGROUND: The spatial and temporal pattern of excessive disease occurrence, termed clustering, may provide clues about the underlying etiology. |
- | Pacific Parkinson' | + | |
- | BACKGROUND: The spatial and temporal pattern of excessive disease occurrence, termed clustering, may provide clues about the underlying etiology. OBJECTIVE: To report the occurrence of 3 clusters of Parkinson disease (PD) in Canada. DESIGN AND PATIENTS: We determined the population groups containing the clusters, geographical limits, and duration of exposure to the specific environments. We tested whether there was an excessive presence of Parkinson disease by calculating the probability of the observed cases occurring under the null hypothesis that the disease developed independently and at random in cluster subjects. Results of genetic testing for mutations in the alpha-synuclein, | + | OBJECTIVE: To report the occurrence of 3 clusters of Parkinson disease (PD) in Canada. |
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+ | DESIGN AND PATIENTS: We determined the population groups containing the clusters, geographical limits, and duration of exposure to the specific environments. We tested whether there was an excessive presence of Parkinson disease by calculating the probability of the observed cases occurring under the null hypothesis that the disease developed independently and at random in cluster subjects. Results of genetic testing for mutations in the alpha-synuclein, | ||
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+ | RESULTS: The probabilities of random occurrence (P values) in the 3 clusters were P = 7.9 x 10 (-7)for cluster 1, P = 2.6 x 10 (-7)for cluster 2, and P = 1.5 x 10 (-7)for cluster 3. | ||
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+ | CONCLUSIONS: | ||
===== Gastrointestinal inflammation ===== | ===== Gastrointestinal inflammation ===== | ||
< | < | ||
- | [[http:// | ||
- | Colonoscopy or flexible | + | Colonoscopy or flexible |
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We propose an alternative third hypothesis, in which both cigarette and coffee consumption change the composition of the microbiota in the gut in a way that mitigates intestinal inflammation. | We propose an alternative third hypothesis, in which both cigarette and coffee consumption change the composition of the microbiota in the gut in a way that mitigates intestinal inflammation. | ||
- | ===== Neuropatholgy | + | ===== Neuropathology |
Nature Reviews Neuroscience 10, 393 (June 2009) | doi: | Nature Reviews Neuroscience 10, 393 (June 2009) | doi: | ||
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Helicobacter. 2005 Oct; | Helicobacter. 2005 Oct; | ||
Abstract | Abstract | ||
- | BACKGROUND: Links between etiology/ | + | |
+ | BACKGROUND: Links between etiology/ | ||
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+ | METHODS: Randomized, double-blind, | ||
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+ | RESULTS: Improvement in stride-length, | ||
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+ | CONCLUSIONS: | ||
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// | // | ||
+ | ===== Recent research and further reading ===== | ||
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+ | < | ||
+ | [[http:// | ||
- | + | {{tag>disease | |
- | {{tag>diseases | + | |
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | --- //Sallie Q 04.09.2017// | + | |
< | < |