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home:diseases:parkinsons [04.10.2017] – [Patients experiences]+headings, pubmed links, re-arranged part of article, removed incomplete tag sallieq | home:diseases:parkinsons [09.14.2022] (current) – external edit 127.0.0.1 | ||
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====== Parkinson' | ====== Parkinson' | ||
- | [[http:// | + | [[https:// |
Clustering of Parkinson disease: shared cause or coincidence? | Clustering of Parkinson disease: shared cause or coincidence? | ||
- | Kumar A, Calne SM, Schulzer M, Mak E, Wszolek Z, Van Netten C, Tsui JK, Stoessl AJ, Calne DB. | + | BACKGROUND: The spatial and temporal pattern of excessive disease occurrence, termed clustering, may provide clues about the underlying etiology. |
- | Pacific Parkinson' | + | |
- | BACKGROUND: The spatial and temporal pattern of excessive disease occurrence, termed clustering, may provide clues about the underlying etiology. OBJECTIVE: To report the occurrence of 3 clusters of Parkinson disease (PD) in Canada. DESIGN AND PATIENTS: We determined the population groups containing the clusters, geographical limits, and duration of exposure to the specific environments. We tested whether there was an excessive presence of Parkinson disease by calculating the probability of the observed cases occurring under the null hypothesis that the disease developed independently and at random in cluster subjects. Results of genetic testing for mutations in the alpha-synuclein, | + | OBJECTIVE: To report the occurrence of 3 clusters of Parkinson disease (PD) in Canada. |
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+ | DESIGN AND PATIENTS: We determined the population groups containing the clusters, geographical limits, and duration of exposure to the specific environments. We tested whether there was an excessive presence of Parkinson disease by calculating the probability of the observed cases occurring under the null hypothesis that the disease developed independently and at random in cluster subjects. Results of genetic testing for mutations in the alpha-synuclein, | ||
+ | |||
+ | RESULTS: The probabilities of random occurrence (P values) in the 3 clusters were P = 7.9 x 10 (-7)for cluster 1, P = 2.6 x 10 (-7)for cluster 2, and P = 1.5 x 10 (-7)for cluster 3. | ||
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+ | CONCLUSIONS: | ||
===== Gastrointestinal inflammation ===== | ===== Gastrointestinal inflammation ===== | ||
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- | [[http:// | ||
- | Colonoscopy or flexible | + | Colonoscopy or flexible |
</ | </ | ||
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- | CONCLUSIONS: | + | CONCLUSIONS: |
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- | We propose an alternative third hypothesis, in which both cigarette and coffee consumption change the composition of the microbiota in the gut in a way that mitigates intestinal inflammation. | + | We propose an alternative third hypothesis, in which both cigarette and coffee consumption change the composition of the microbiota in the gut in a way that mitigates intestinal inflammation. |
===== Neuropathology ===== | ===== Neuropathology ===== | ||
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< | < | ||
Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 2: response of facets of clinical idiopathic parkinsonism to Helicobacter pylori eradication. A randomized, double-blind, | Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 2: response of facets of clinical idiopathic parkinsonism to Helicobacter pylori eradication. A randomized, double-blind, | ||
- | Bjarnason IT, Charlett A, Dobbs RJ, Dobbs SM, Ibrahim MA, Kerwin RW, Mahler RF, Oxlade NL, Peterson DW, Plant JM, Price AB, Weller C. (({{pubmed> | + | Bjarnason IT, Charlett A, Dobbs RJ, Dobbs SM, Ibrahim MA, Kerwin RW, Mahler RF, Oxlade NL, Peterson DW, Plant JM, Price AB, Weller C. (({{pmid> |
Section of Neuropharmacology, | Section of Neuropharmacology, | ||
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Helicobacter. 2005 Oct; | Helicobacter. 2005 Oct; | ||
Abstract | Abstract | ||
- | BACKGROUND: Links between etiology/ | + | |
+ | BACKGROUND: Links between etiology/ | ||
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+ | METHODS: Randomized, double-blind, | ||
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+ | RESULTS: Improvement in stride-length, | ||
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+ | CONCLUSIONS: | ||
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< | < | ||
- | http:// | + | https:// |
NEW ORLEANS, LA – May 22, 2011 -- The stomach bacteria responsible for ulcers could also play a role in the development of Parkinson' | NEW ORLEANS, LA – May 22, 2011 -- The stomach bacteria responsible for ulcers could also play a role in the development of Parkinson' | ||
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Studies in the Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. | Studies in the Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. | ||
- | AIM: To consider the candidature of Helicobacter in parkinsonism with cachexia. (({{pubmed> | + | AIM: To consider the candidature of Helicobacter in parkinsonism with cachexia. (({{pmid> |
- | AIM: Proof-of-principle that infection contributes to idiopathic parkinsonism. (({{pubmed> | + | AIM: Proof-of-principle that infection contributes to idiopathic parkinsonism. (({{pmid> |
- | AIM: To explore the cross-sectional fit of parkinsonism as an extra-alimentary consequence of Helicobacter pylori, using the serum antibody profile. (({{pubmed> | + | AIM: To explore the cross-sectional fit of parkinsonism as an extra-alimentary consequence of Helicobacter pylori, using the serum antibody profile. (({{pmid> |
- | Abstract: We challenge the concept of idiopathic parkinsonism (IP) as inevitably progressive neurodegeneration (({{pubmed> | + | Abstract: We challenge the concept of idiopathic parkinsonism (IP) as inevitably progressive neurodegeneration (({{pmid> |
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Abstract | Abstract | ||
- | Antibiotic therapy to eradicate Helicobacter pylori, the causative agent of gastric and duodenal ulcers, has been suggested to improve L-DOPA bioavailability in Parkinson' | + | Antibiotic therapy to eradicate Helicobacter pylori, the causative agent of gastric and duodenal ulcers, has been suggested to improve L-DOPA bioavailability in Parkinson' |
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- | I know one other person on the MP who thinks he has Parkinson' | + | I know one other person on the MP who thinks he has Parkinson' |
// | // | ||
- | ===== Further | + | ===== Research and further |
- | [[http://books.google.com/books? | + | < |
- | {{tag>diseases | + | < |
+ | The implication of tyrosine hydroxylase (TH), the enzyme that catalyzes the formation of L-3, | ||
+ | [[https:// | ||
+ | |||
+ | {{tag> | ||
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+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | --- //Sallie Q 04.09.2017// | + | |
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- | ===== References ===== | + | ===== References =====</ |