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home:diseases:parkinsons [01.10.2019]
sallieq [Gastrointestinal inflammation]
home:diseases:parkinsons [02.17.2019]
sallieq [Recent research and further reading]
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 Helicobacter. 2005 Oct;​10(5):​557. Bjarnason, Inguar T [corrected to Bjarnason, Ingvar T]. Helicobacter. 2005 Oct;​10(5):​557. Bjarnason, Inguar T [corrected to Bjarnason, Ingvar T].
 Abstract Abstract
-BACKGROUND: Links between etiology/​pathogenesis of neuropsychiatric disease and infection are increasingly recognized. AIM: Proof-of-principle that infection contributes to idiopathic parkinsonism. METHODS: Randomized, double-blind,​ placebo-controlled efficacy study of proven Helicobacter pylori eradication on the time course of facets of parkinsonism. Intervention was 1 week's triple eradication therapy/​placebos. Routine deblinding at 1 year (those still infected received open-active),​ with follow-up to 5 years post-eradication. Primary outcome was mean stride length at free-walking speed, sample size 56 for a difference, active vs. placebo, of 3/4 (between-subject standard deviation). Recruitment of subjects with idiopathic parkinsonism and H. pylori infection was stopped at 31, because of marked deterioration with eradication failure. Interim analysis was made in the 20 who had reached deblinding, seven of whom were receiving antiparkinsonian medication (long-t(1/​2),​ evenly spaced) which remained unchanged. RESULTS: Improvement in stride-length,​ on active (n = 9) vs. placebo (11), exceeded size of effect on which the sample size was calculated when analyzed on intention-to-treat basis (p = .02), and on protocol analysis of six weekly assessments,​ including (p = .02) and excluding (p = .05) those on antiparkinsonian medication. Active eradication (blind or open) failed in 4/20, in whom B-lymphocyte count was lower. Their mean time course was: for stride-length,​ -243 (95% CI -427, -60) vs. 45 (-10, 100) mm/year in the remainder (p = .001); for the ratio, torque to extend to flex relaxed arm, 349 (146, 718) vs. 58 (27, 96)%/ year (p < .001); and for independently rated, visual-analog scale of stance-walk videos (worst-best per individual identical with 0-100 mm), -64 vs. -3 mm from anterior and -50 vs. 11 lateral (p = .004 and .02). CONCLUSIONS:​ Interim analysis points to a direct or surrogate (not necessarily unique) role of a particular infection in the pathogenesis of parkinsonism. With eradication failure, bolus release of antigen from killed bacteria could aggravate an effect of ongoing infection.+ 
 +BACKGROUND: Links between etiology/​pathogenesis of neuropsychiatric disease and infection are increasingly recognized. AIM: Proof-of-principle that infection contributes to idiopathic parkinsonism. ​ 
 + 
 +METHODS: Randomized, double-blind,​ placebo-controlled efficacy study of proven Helicobacter pylori eradication on the time course of facets of parkinsonism. Intervention was 1 week's triple eradication therapy/​placebos. Routine deblinding at 1 year (those still infected received open-active),​ with follow-up to 5 years post-eradication. Primary outcome was mean stride length at free-walking speed, sample size 56 for a difference, active vs. placebo, of 3/4 (between-subject standard deviation). Recruitment of subjects with idiopathic parkinsonism and H. pylori infection was stopped at 31, because of marked deterioration with eradication failure. Interim analysis was made in the 20 who had reached deblinding, seven of whom were receiving antiparkinsonian medication (long-t(1/​2),​ evenly spaced) which remained unchanged. ​ 
 + 
 +RESULTS: Improvement in stride-length,​ on active (n = 9) vs. placebo (11), exceeded size of effect on which the sample size was calculated when analyzed on intention-to-treat basis (p = .02), and on protocol analysis of six weekly assessments,​ including (p = .02) and excluding (p = .05) those on antiparkinsonian medication. Active eradication (blind or open) failed in 4/20, in whom B-lymphocyte count was lower. Their mean time course was: for stride-length,​ -243 (95% CI -427, -60) vs. 45 (-10, 100) mm/year in the remainder (p = .001); for the ratio, torque to extend to flex relaxed arm, 349 (146, 718) vs. 58 (27, 96)%/ year (p < .001); and for independently rated, visual-analog scale of stance-walk videos (worst-best per individual identical with 0-100 mm), -64 vs. -3 mm from anterior and -50 vs. 11 lateral (p = .004 and .02).  
 + 
 +CONCLUSIONS:​ Interim analysis points to a direct or surrogate (not necessarily unique) role of a particular infection in the pathogenesis of parkinsonism. With eradication failure, bolus release of antigen from killed bacteria could aggravate an effect of ongoing infection.
  
  
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 <​blockquote>​Towards this end, we used a published dataset to analyse bacteriophage composition and determine the phage/​bacteria ratio in faecal samples from drug-naive PD patients and healthy participants. Our analyses revealed significant alterations in the representation of certain bacteriophages in the phagobiota of PD patients. (({{pubmed>​long:​30018338}})) </​blockquote>​ <​blockquote>​Towards this end, we used a published dataset to analyse bacteriophage composition and determine the phage/​bacteria ratio in faecal samples from drug-naive PD patients and healthy participants. Our analyses revealed significant alterations in the representation of certain bacteriophages in the phagobiota of PD patients. (({{pubmed>​long:​30018338}})) </​blockquote>​
 +
 +<​blockquote>​In 1919, it was first recognized that loss of pigmentation in the substantia nigra of the midbrain is a feature ​  ​(({{pubmed>​long:​29261972}})) ​  </​blockquote>​
  
 [[http://​books.google.com/​books?​id=REICWr22YR8C&​dq=Parkinson'​s:​+another+look.+Is+Parkinson'​s+disease+caused+by+a+bacteria%3F&​printsec=frontcover&​source=bn&​hl=en&​ei=Khj-SZmdFaCltgegm62SDA&​sa=X&​oi=book_result&​ct=result&​resnum=4|Parkinson'​s Another Look]] [[http://​books.google.com/​books?​id=REICWr22YR8C&​dq=Parkinson'​s:​+another+look.+Is+Parkinson'​s+disease+caused+by+a+bacteria%3F&​printsec=frontcover&​source=bn&​hl=en&​ei=Khj-SZmdFaCltgegm62SDA&​sa=X&​oi=book_result&​ct=result&​resnum=4|Parkinson'​s Another Look]]
home/diseases/parkinsons.txt · Last modified: 07.04.2019 by sallieq
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