You are here: Welcome to the MPKB » Welcome to the MPKB » Diseases » Periodontal disease and gingivitis
Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
Next revisionBoth sides next revision
home:diseases:periodontal [08.29.2012] – [Other diseases] paulalberthome:diseases:periodontal [01.25.2019] – ["Healthy" bacteria play surprising role in gum disease] sallieq
Line 73: Line 73:
   * **Pancreatic cancer** – Particular types of mouth bacteria, some of which are found in gum disease, are associated with the development of pancreatic cancer, indicates a small study published online in the journal //Gut//.(({{pubmed>long:21994333}})) The authors base their findings on an initial comparison of the bacteria found in the spit of 10 patients with pancreatic cancer, which had not yet spread, and 10 healthy people, matched for age and sex. They found significant differences between the bacterial colonies in the two groups, with 31 additional species and 25 fewer species in the spit of the cancer patients. They then checked spit samples from a further 28 pancreatic cancer patients and 28 healthy people to verify their findings. And they checked tissue samples from 28 patients with chronic inflammation of the pancreas (chronic pancreatitis), which is associated with an increased risk of developing pancreatic cancer. Among six suspicious species, two -- //Neisseria elongata// and //Streptococcus mitis// -- showed up significantly less often in the mouths of the cancer patients than in those of their healthy peers, while levels of another species -- //Granulicatella adjacens// -- were significantly higher. The combination of //N. elongata// and //S. mitis// accurately differentiated between healthy patients and those with cancer in more than 80% cases. Furthermore, they found similar differences in the prevalence of //S. mitis// and //G. adjacens// between the chronic pancreatitis samples and the spit of healthy people.   * **Pancreatic cancer** – Particular types of mouth bacteria, some of which are found in gum disease, are associated with the development of pancreatic cancer, indicates a small study published online in the journal //Gut//.(({{pubmed>long:21994333}})) The authors base their findings on an initial comparison of the bacteria found in the spit of 10 patients with pancreatic cancer, which had not yet spread, and 10 healthy people, matched for age and sex. They found significant differences between the bacterial colonies in the two groups, with 31 additional species and 25 fewer species in the spit of the cancer patients. They then checked spit samples from a further 28 pancreatic cancer patients and 28 healthy people to verify their findings. And they checked tissue samples from 28 patients with chronic inflammation of the pancreas (chronic pancreatitis), which is associated with an increased risk of developing pancreatic cancer. Among six suspicious species, two -- //Neisseria elongata// and //Streptococcus mitis// -- showed up significantly less often in the mouths of the cancer patients than in those of their healthy peers, while levels of another species -- //Granulicatella adjacens// -- were significantly higher. The combination of //N. elongata// and //S. mitis// accurately differentiated between healthy patients and those with cancer in more than 80% cases. Furthermore, they found similar differences in the prevalence of //S. mitis// and //G. adjacens// between the chronic pancreatitis samples and the spit of healthy people.
   * **obesity** – A 2011 cross-sectional study of obese adolescents versus normal weight subjects collected saliva performed a metagenomic analysis on that saliva. The study found that obese subjects had //Campylobacter rectus// and //Neisseria mucosa// in sixfold higher amounts than controls.[cite needed]((Microbiota in the Oral Subgingival Biofilm))   * **obesity** – A 2011 cross-sectional study of obese adolescents versus normal weight subjects collected saliva performed a metagenomic analysis on that saliva. The study found that obese subjects had //Campylobacter rectus// and //Neisseria mucosa// in sixfold higher amounts than controls.[cite needed]((Microbiota in the Oral Subgingival Biofilm))
-  * **joint failure** – DNA testing of bacteria in synovial fluid, which lubricates hip and knee joints, had bacteria with the same DNA as the plaque from patients with gum disease and in need of a joint replacement.(({{pubmed>long:22426587}}))  +  * **joint failure** – In a study of 36 patients with hip or knee joint failure, bacterial DNA from the synovial fluid was found to match microbial DNA from periodontal tissue in five patients.(({{pubmed>long:22426587}}))  
  
  
Line 137: Line 137:
  
 {{section>:home:othertreatments:probiotics#healthy_bacteria_play_surprising_role_in_gum_disease&noheader&firstseconly}} {{section>:home:othertreatments:probiotics#healthy_bacteria_play_surprising_role_in_gum_disease&noheader&firstseconly}}
 +
 +===== Recent research =====
 +
 +In general, the mouth harbors at least six billion bacteria which are represented by more than 700 species (Theilade, 1990; Aas et al., 2005), as well as other types of microorganisms, including fungi, mycoplasma, protozoa, and possibly even viruses (Pennisi, 2005).
 +
 +Despite the diverse community of oral microbiota, the oral cavity is, nonetheless, characterized by a stable community known as the climax community. Therefore, if imbalance in the oral resident microbiota occurs, oral diseases such as caries and periodontal diseases seem to appear, leading to multiplication of potentially pathogenic microorganisms. 
 +
 +While human subgingival plaque harbors more than 500 bacterial species, considerable research has shown that Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is the major etiologic agent which contributes to chronic periodontitis. This black-pigmented bacterium produces a myriad of virulence factors that cause destruction to periodontal tissues either directly or indirectly by modulating the host inflammatory response. 
 +
 +Various studies have shown that periodontitis occurs more often among patients with systemic diseases such as diabetes mellitus, AIDS, leukemia, and Down’s syndrome. (({{pubmed>long:26903954}})) 
 +
 +  (({{pubmed>long:000}})) 
 +
 +  (({{pubmed>long:000}})) 
 ===== Patients experiences ===== ===== Patients experiences =====
  
Line 145: Line 159:
 //**Sue Lyons,** MarshallProtocol.com//</blockquote>  //**Sue Lyons,** MarshallProtocol.com//</blockquote> 
  
 +
 +
 +<blockquote>
 +
 +The recessed area of my gums have in fact filled in now.  Nice!
 +
 +//**Cynthia Schnitz**, MarshallProtocol.com//</blockquote>
  
  
Line 256: Line 277:
  
  
-{{tag>diseases}} +{{tag>disease}}
 ===== Notes and comments ===== ===== Notes and comments =====
  
Line 301: Line 321:
  
 PMID: 20656903</blockquote> PMID: 20656903</blockquote>
 +
  
 ===== References ===== ===== References =====
home/diseases/periodontal.txt · Last modified: 09.14.2022 by 127.0.0.1
© 2015, Autoimmunity Research Foundation. All Rights Reserved.