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home:diseases:periodontal [01.25.2019] – [Notes and comments] sallieq | home:diseases:periodontal [09.14.2022] (current) – external edit 127.0.0.1 | ||
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- | The tooth provides a surface for the colonization of a diverse array of bacterial species. Bacteria may attach to the tooth itself, to the epithelial surfaces (surface-lining tissue) of the gingiva or periodontal pocket, to underlying connective tissues, if exposed, and to other bacteria attached to these surfaces. In contrast to the outer surface of most parts of the body, the outer layers of the tooth do not shed, and thus microbial colonization (accumulation) is facilitated.(({{pubmed> | + | The tooth provides a surface for the colonization of a diverse array of bacterial species. Bacteria may attach to the tooth itself, to the epithelial surfaces (surface-lining tissue) of the gingiva or periodontal pocket, to underlying connective tissues, if exposed, and to other bacteria attached to these surfaces. In contrast to the outer surface of most parts of the body, the outer layers of the tooth do not shed, and thus microbial colonization (accumulation) is facilitated.(({{pmid> |
- | Periodontal disease is broadly classified as either gingivitis (inflammation of the gums) or periodontitis (inflammation of the ligaments and bones). Periodontitis is an ancient disease — fossil evidence demonstrates that our early ancestors experienced the localized alveolar bone loss around tooth root surfaces that is a hallmark of the disease. The loss of this bone, which supports the root structure of the tooth, leads to the eventual loss of the tooth.(({{pubmed> | + | Periodontal disease is broadly classified as either gingivitis (inflammation of the gums) or periodontitis (inflammation of the ligaments and bones). Periodontitis is an ancient disease — fossil evidence demonstrates that our early ancestors experienced the localized alveolar bone loss around tooth root surfaces that is a hallmark of the disease. The loss of this bone, which supports the root structure of the tooth, leads to the eventual loss of the tooth.(({{pmid> |
While gingivitis is a reversible condition, affecting only the gingival tissue, it is a precursor to periodontitis. The transition from gingivitis to periodontitis may vary from weeks to years. Periodontitis is associated with attachment loss (teeth falling out) or alveolar bone loss. | While gingivitis is a reversible condition, affecting only the gingival tissue, it is a precursor to periodontitis. The transition from gingivitis to periodontitis may vary from weeks to years. Periodontitis is associated with attachment loss (teeth falling out) or alveolar bone loss. | ||
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* **periodontal disease** – disease that affect one or more of the periodontal tissues; broadly classified as either gingivitis or periodontitis | * **periodontal disease** – disease that affect one or more of the periodontal tissues; broadly classified as either gingivitis or periodontitis | ||
* **periodontitis** – inflammation and infection of the ligaments and bones that support the teeth (alveolar bone) | * **periodontitis** – inflammation and infection of the ligaments and bones that support the teeth (alveolar bone) | ||
- | * **gingivitis** – inflammation of the gums (gingiva); gingivitis always precedes periodontitis; | + | * **gingivitis** – inflammation of the gums (gingiva); gingivitis always precedes periodontitis; |
- | Periodontitis is a major cause of tooth loss in adults. Almost 15 percent of the population in the United States (50 million) suffer from significant periodontal disease.(({{pubmed> | + | Periodontitis is a major cause of tooth loss in adults. Almost 15 percent of the population in the United States (50 million) suffer from significant periodontal disease.(({{pmid> |
- | [{{ : | + | [{{ : |
===== Detecting bacteria ===== | ===== Detecting bacteria ===== | ||
< | < | ||
- | Given its accessibility, | + | Given its accessibility, |
==== Culture-based studies ==== | ==== Culture-based studies ==== | ||
- | Culture-based studies have long identified substantial and diverse groups of bacteria living in the oral cavity. For example, in a 1971 analysis of the gingival crevice of healthy adults, the total microscopic counts averaged 2.7 x 10< | + | Culture-based studies have long identified substantial and diverse groups of bacteria living in the oral cavity. For example, in a 1971 analysis of the gingival crevice of healthy adults, the total microscopic counts averaged 2.7 x 10< |
==== Molecular analyses ==== | ==== Molecular analyses ==== | ||
- | However, results of surveys with molecular tools indicate a level of diversity in the human subgingival microflora that cannot be recognized by conventional culture techniques.(({{pubmed> | + | However, results of surveys with molecular tools indicate a level of diversity in the human subgingival microflora that cannot be recognized by conventional culture techniques.(({{pmid> |
- | In 2009, Nasidze //et al.// used 16S ribosomal RNA (rRNA) sequences from saliva samples from 120 healthy individuals (10 individuals from each of 12 worldwide locations).(({{pubmed> | + | In 2009, Nasidze //et al.// used 16S ribosomal RNA (rRNA) sequences from saliva samples from 120 healthy individuals (10 individuals from each of 12 worldwide locations).(({{pmid> |
===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
- | Overwhelming data exist indicating that bacteria initiate the major mechanisms of destruction of the periodontium.(({{pubmed> | + | Overwhelming data exist indicating that bacteria initiate the major mechanisms of destruction of the periodontium.(({{pmid> |
- | * **Correlation between plaque and gingivitis** – There is a positive correlation between the amount of bacterial plaque and the severity of gingivitis and amount of bone loss in cross-sectional studies of human populations.(({{pubmed> | + | * **Correlation between plaque and gingivitis** – There is a positive correlation between the amount of bacterial plaque and the severity of gingivitis and amount of bone loss in cross-sectional studies of human populations.(({{pmid> |
- | * **Antibody response to microbes** – Numerous studies indicate that subjects with destructive periodontal diseases show an elevated serum antibody response to specific subgingival organisms.(({{pubmed> | + | * **Antibody response to microbes** – Numerous studies indicate that subjects with destructive periodontal diseases show an elevated serum antibody response to specific subgingival organisms.(({{pmid> |
- | * **Pathogenic potential of plaque bacteria** – Human bacterial plaque has demonstrated pathogenic potential when implanted into outside the mouth to sites such as subcutaneous destructive abscesses in humans or in experimental animals. A number of toxic products can be detected in dental plaque, including endotoxins, and cell wall mucopeptides. In addition, enzymes have been shown to be produced by whole plaque or individual microorganisms from plaque that can be demonstrated to hydrolyze a wide variety of tissue constituents. Finally, it must be pointed out that the bacterial masses that accumulate at or in the gingival sulcus possess an array of antigens and possibly polyclonal activators capable of triggering sequences of host-mediated events that have been postulated as mechanisms of tissue destruction.(({{pubmed> | + | * **Pathogenic potential of plaque bacteria** – Human bacterial plaque has demonstrated pathogenic potential when implanted into outside the mouth to sites such as subcutaneous destructive abscesses in humans or in experimental animals. A number of toxic products can be detected in dental plaque, including endotoxins, and cell wall mucopeptides. In addition, enzymes have been shown to be produced by whole plaque or individual microorganisms from plaque that can be demonstrated to hydrolyze a wide variety of tissue constituents. Finally, it must be pointed out that the bacterial masses that accumulate at or in the gingival sulcus possess an array of antigens and possibly polyclonal activators capable of triggering sequences of host-mediated events that have been postulated as mechanisms of tissue destruction.(({{pmid> |
- | * **Experimental animal models** – Studies in experimental animals have added considerable support to the hypothesis of the significant role of microorganisms in the etiology of periodontal disease. | + | * **Experimental animal models** – Studies in experimental animals have added considerable support to the hypothesis of the significant role of microorganisms in the etiology of periodontal disease. |
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- | * **[[home: | + | * **[[home: |
- | * **[[home: | + | * **[[home: |
- | * **Pancreatic cancer** – Particular types of mouth bacteria, some of which are found in gum disease, are associated with the development of pancreatic cancer, indicates a small study published online in the journal // | + | * **Pancreatic cancer** – Particular types of mouth bacteria, some of which are found in gum disease, are associated with the development of pancreatic cancer, indicates a small study published online in the journal // |
* **obesity** – A 2011 cross-sectional study of obese adolescents versus normal weight subjects collected saliva performed a metagenomic analysis on that saliva. The study found that obese subjects had // | * **obesity** – A 2011 cross-sectional study of obese adolescents versus normal weight subjects collected saliva performed a metagenomic analysis on that saliva. The study found that obese subjects had // | ||
- | * **joint failure** – In a study of 36 patients with hip or knee joint failure, bacterial DNA from the synovial fluid was found to match microbial DNA from periodontal tissue in five patients.(({{pubmed> | + | * **joint failure** – In a study of 36 patients with hip or knee joint failure, bacterial DNA from the synovial fluid was found to match microbial DNA from periodontal tissue in five patients.(({{pmid> |
==== Cause vs. effect==== | ==== Cause vs. effect==== | ||
- | The correlations seen between periodontal disease and cardiovascular disease could be related to the transmission of microbes from one infectious site to another. However, it seems more likely that when periodontal disease arises at the same time as other inflammatory conditions, these conditions are the result of the same underlying disease process. In this sense, periodontal disease does not necessarily cause cardiovascular disease, or vise versa. Rather, as the immune system in the entire body is weakened by an increasingly pathogenic microbiota, the body finds it more difficult to control microbial virulence in several body sites at once. Notably, // | + | The correlations seen between periodontal disease and cardiovascular disease could be related to the transmission of microbes from one infectious site to another. However, it seems more likely that when periodontal disease arises at the same time as other inflammatory conditions, these conditions are the result of the same underlying disease process. In this sense, periodontal disease does not necessarily cause cardiovascular disease, or vise versa. Rather, as the immune system in the entire body is weakened by an increasingly pathogenic microbiota, the body finds it more difficult to control microbial virulence in several body sites at once. Notably, // |
===== Successive infection ===== | ===== Successive infection ===== | ||
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- | Microorganisms were first considered as possible aetiological agents of periodontitis in the late 1800s, when the germ theory of disease changed our understanding of disease aetiologies. Failure to identify a specific pathogen in the polymicrobial community dampened the enthusiasm for a microbial aetiology, and other causes for perionditis, | + | Microorganisms were first considered as possible aetiological agents of periodontitis in the late 1800s, when the germ theory of disease changed our understanding of disease aetiologies. Failure to identify a specific pathogen in the polymicrobial community dampened the enthusiasm for a microbial aetiology, and other causes for perionditis, |
- | Today, periodontal disease may be the most widely accepted example of successive infection, an infectious cascade of pathogens in which initial infectious agents slow the immune response and make it easier for subsequent infections to proliferate. Consistent with successive infection, no single bacterial species has been shown to be responsible for triggering the inflammatory host responses seen in periodontal disease.(({{pubmed> | + | Today, periodontal disease may be the most widely accepted example of successive infection, an infectious cascade of pathogens in which initial infectious agents slow the immune response and make it easier for subsequent infections to proliferate. Consistent with successive infection, no single bacterial species has been shown to be responsible for triggering the inflammatory host responses seen in periodontal disease.(({{pmid> |
- | < | + | < |
- | //**Richard P. Darveau**// (({{pubmed> | + | //**Richard P. Darveau**// (({{pmid> |
- | Three of the periodontal pathogens, // | + | Three of the periodontal pathogens, // |
==== Synergistic activity of periodontal microbiota ==== | ==== Synergistic activity of periodontal microbiota ==== | ||
- | In a 2007 study, groups of rats were infected with either // | + | In a 2007 study, groups of rats were infected with either // |
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===== Periodontal microbes slow innate immune activity ===== | ===== Periodontal microbes slow innate immune activity ===== | ||
- | In healthy periodontal tissue, all microbes, even commensal bacteria, elicit a robust innate immune response.(({{pubmed> | + | In healthy periodontal tissue, all microbes, even commensal bacteria, elicit a robust innate immune response.(({{pmid> |
- | * **Inhibition of the chemokine IL-8** – IL-8 is an important chemokine responsible for recruiting neutrophils to phagocytose the antigen, which in triggers the antigen pattern toll-like receptors such as TLR4. //P. gingivalis//, | + | * **Inhibition of the chemokine IL-8** – IL-8 is an important chemokine responsible for recruiting neutrophils to phagocytose the antigen, which in triggers the antigen pattern toll-like receptors such as TLR4. //P. gingivalis//, |
- | * **Modulation of signalling in "lipid rafts" | + | * **Modulation of signalling in "lipid rafts" |
- | * **Directly antagonizing TLR4 through production of Lipid A** – The red-complex bacteria have been shown to also inhibit innate host defense by producing a lipid A structure that acts as a TLR4 antagonist. One experiment showed that a TLR4 antagonist decreased beta-defensin expression, a key family of antimicrobial peptides.(({{pubmed> | + | * **Directly antagonizing TLR4 through production of Lipid A** – The red-complex bacteria have been shown to also inhibit innate host defense by producing a lipid A structure that acts as a TLR4 antagonist. One experiment showed that a TLR4 antagonist decreased beta-defensin expression, a key family of antimicrobial peptides.(({{pmid> |
- | The naturally occurring proteins in the human salivary proteins varies according to age.(({{pubmed> | + | The naturally occurring proteins in the human salivary proteins varies according to age.(({{pmid> |
===== Pathophysiology of alveolar bone and teeth resorption ===== | ===== Pathophysiology of alveolar bone and teeth resorption ===== | ||
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===== Microbes adhere to some root canal filling materials and sealers ===== | ===== Microbes adhere to some root canal filling materials and sealers ===== | ||
- | Certain microorganisms have a high affinity to some root canal filling materials and sealers, especially to one named " | + | Certain microorganisms have a high affinity to some root canal filling materials and sealers, especially to one named " |
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While human subgingival plaque harbors more than 500 bacterial species, considerable research has shown that Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is the major etiologic agent which contributes to chronic periodontitis. This black-pigmented bacterium produces a myriad of virulence factors that cause destruction to periodontal tissues either directly or indirectly by modulating the host inflammatory response. | While human subgingival plaque harbors more than 500 bacterial species, considerable research has shown that Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is the major etiologic agent which contributes to chronic periodontitis. This black-pigmented bacterium produces a myriad of virulence factors that cause destruction to periodontal tissues either directly or indirectly by modulating the host inflammatory response. | ||
- | Various studies have shown that periodontitis occurs more often among patients with systemic diseases such as diabetes mellitus, AIDS, leukemia, and Down’s syndrome. (({{pubmed> | + | Various studies have shown that periodontitis occurs more often among patients with systemic diseases such as diabetes mellitus, AIDS, leukemia, and Down’s syndrome. (({{pmid> |
- | Oil pulling is a traditional folk remedy practiced in ancient India. It is believed to cure more than thirty systemic diseases when practiced regularly and as directed. | + | Oil pulling is a traditional folk remedy practiced in ancient India. It is believed to cure more than thirty systemic diseases when practiced regularly and as directed. |
===== Patients experiences ===== | ===== Patients experiences ===== | ||
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{{tag> | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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- | (({{pubmed> | + | (({{pmid> |
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- | ===== References ===== | + | ===== References =====</ |