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home:diseases:psoriasis [08.28.2012] – paulalbert | home:diseases:psoriasis [08.30.2012] – paulalbert | ||
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+ | Psoriasis is an autoimmune disease that affects the skin that varies in severity from minor localized patches to complete body coverage. | ||
+ | The Marshall Protocol treats psoriasis by reactivating the innate immune response. In the course of treatment, patients' | ||
- | ==== L-forms ==== | ||
- | * **psoriasis** – In a 2009 study, Wang investigated the carriage rate of cell wall deficient bacteria in the tonsil or pharynx of psoriasis patients. CWDB were isolated from 74.2% of psoriasis patients, 23.5% of chronic tonsillitis patients and only 6.3% of controls. Meanwhile, our study showed that CWDB and wide-type bacteria significantly enhanced the production of IFN-gamma, in vitro, and peripheral blood mononuclear cells proliferation.(({{pubmed> | + | ===== Skin microbiome ===== |
+ | {{section>: | ||
- | J Clin Microbiol. 2006 Aug; | ||
- | Molecular analysis of fungal microbiota in samples from healthy human skin and psoriatic lesions. | + | [{{ : |
- | Paulino LC, Tseng CH, Strober BE, Blaser MJ. | + | |
- | Department | + | |
- | Psoriasis, a common cutaneous disease of unknown etiology, may be triggered by infections, including those due to fungi. Since the fungal community of human skin is poorly characterized, | ||
- | PMID: 16891514 | + | ===== Evidence of infectious cause ===== |
+ | * **cell wall deficient bacteria** – In a 2009 study, Wang investigated the carriage rate of cell wall deficient bacteria in the tonsil or pharynx of psoriasis patients. Cell wall deficient bacteria, a term often used interchangeably with l-form, were isolated from 74.2% of psoriasis patients, 23.5% of chronic tonsillitis patients and only 6.3% of controls.(({{pubmed> | ||
+ | * **differences in microbiota between psoriasis and normal skin** – A 2008 study of psoriatic skin not only found 84 novel species never before known to persist in skin, but also double the proportion of microbes from the // | ||
- | Exp Dermatol. 2010 Aug; | ||
- | Topical calcitriol protects from UV-induced genetic damage but suppresses cutaneous immunity in humans. | ||
- | Damian DL, Kim YJ, Dixon KM, Halliday GM, Javeri A, Mason RS. | ||
- | Dermatology, | ||
- | Abstract | ||
- | Calcitriol, the biologically active form of vitamin D, has been reported to cause both suppressive and protective immune effects in mice. Its immune effects in vivo in humans are unclear. We investigated the in vivo effects of topical calcitriol on minimal erythema dose and skin immune responses in healthy volunteers. We found that calcitriol did not protect from ultraviolet (UV)-induced erythema (sunburn) when applied either 24 h before or immediately after irradiation, | ||
- | PMID: 19758324 | ||
+ | Superantigens(({{pubmed> | ||
- | < | + | microorganisms and psoriasis(({{pubmed>long:8040907}})) |
- | Narrow-band ultraviolet-B | + | (({{pubmed>long: |
- | </ | + | |
- | ===== Evidence of infectious cause ===== | + | |
- | Superantigens(({{pubmed> | ||
- | microorganisms and psoriasis(({{pubmed> | ||
+ | |||
+ | ===== Other treatments ===== | ||
+ | |||
+ | For many physicians, immunosuppressive medications are a first-line treatment for psoriasis. These drugs suppress the innate immune response, which provides some patients with temporary symptom palliation, because they reduce immunopathology, | ||
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+ | |||
+ | * **corticosteroids** – For even short periods of time, steroid use can become genuinely addictive. Research shows that any kind of short-term symptomatic improvement from corticosteroid use does not last, and that over the longer term, use of the drugs entales a litany of side effects. For their own safety, patients on the Marshall Protocol (MP) must [[home: | ||
+ | * **TNF-alpha inhibitors** – Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance.(({{pubmed> | ||
+ | * **methotrexate** – Methotrexate (MTX) is an antibiotic that interferes with bacteria' | ||
+ | * **[[home: | ||
- | (({{pubmed> | ||
- | [{{ : | ||
===== Patient interviews | ===== Patient interviews | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
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- | GETCONTENT | ||
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- | * legacy content | ||
- | * | ||
===== References ===== | ===== References ===== |