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home:diseases:psoriasis [08.28.2012] – paulalbert | home:diseases:psoriasis [08.30.2012] – paulalbert | ||
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+ | Psoriasis is an autoimmune disease that affects the skin that varies in severity from minor localized patches to complete body coverage. | ||
+ | The Marshall Protocol treats psoriasis by reactivating the innate immune response. In the course of treatment, patients' | ||
- | ==== L-forms | + | ===== Skin microbiome ===== |
- | * **psoriasis** – In a 2009 study, Wang investigated the carriage rate of cell wall deficient bacteria in the tonsil or pharynx of psoriasis patients. CWDB were isolated from 74.2% of psoriasis patients, 23.5% of chronic tonsillitis patients and only 6.3% of controls. Meanwhile, our study showed that CWDB and wide-type bacteria significantly enhanced the production of IFN-gamma, in vitro, and peripheral blood mononuclear cells proliferation.(({{pubmed> | ||
+ | {{section>: | ||
- | J Clin Microbiol. 2006 Aug;44(8):2933-41.Links | + | [{{ :home: |
- | Molecular analysis of fungal microbiota in samples from healthy human skin and psoriatic lesions. | ||
- | Paulino LC, Tseng CH, Strober BE, Blaser MJ. | ||
- | Department of Medicine, New York University School of Medicine, 550 First Ave., OBV-A 606, New York, NY 10016, USA. | ||
- | Psoriasis, a common cutaneous disease | + | ===== Evidence |
- | PMID: 16891514 | + | * **cell wall deficient bacteria** – In a 2009 study, Wang investigated the carriage rate of cell wall deficient bacteria in the tonsil or pharynx of psoriasis patients. Cell wall deficient bacteria, a term often used interchangeably with l-form, were isolated from 74.2% of psoriasis patients, 23.5% of chronic tonsillitis patients and only 6.3% of controls.(({{pubmed> |
+ | * **differences in microbiota between psoriasis and normal skin** – A 2008 study of psoriatic skin not only found 84 novel species never before known to persist in skin, but also double the proportion of microbes from the // | ||
+ | * **bacterial DNA in blood of psoriatic patients** – Peripheral blood samples from 20 patients with psoriasis and from 16 control subjects were studied for the presence of bacteria by PCR using universal 16S ribosomal DNA primers and specific primers for S. pyogenes. Sequence analysis of amplified 16S rRNA sequences was used to determine taxonomic identity. Ribosomal bacterial DNA was detected in the blood of all 20 patients with psoriasis, but in none of the controls.(({{pubmed> | ||
- | Exp Dermatol. 2010 Aug; | ||
- | Topical calcitriol protects from UV-induced genetic damage but suppresses cutaneous immunity in humans. | ||
- | Damian DL, Kim YJ, Dixon KM, Halliday GM, Javeri A, Mason RS. | ||
- | Dermatology, | ||
- | Abstract | ||
- | Calcitriol, the biologically active form of vitamin D, has been reported to cause both suppressive and protective immune effects in mice. Its immune effects in vivo in humans are unclear. We investigated the in vivo effects of topical calcitriol on minimal erythema dose and skin immune responses in healthy volunteers. We found that calcitriol did not protect from ultraviolet (UV)-induced erythema (sunburn) when applied either 24 h before or immediately after irradiation, | ||
- | PMID: 19758324 | ||
- | < | ||
- | Narrow-band ultraviolet-B (NB-UVB) phototherapy is an effective treatment for psoriasis. The molecular mechanisms underlying its efficacy are incompletely understood. To identify NB-UVB-induced molecular pathways that may account for its anti-inflammatory efficacy, gene expression profiling was performed using epidermal RNA from lesional and nonlesional skin from patients with psoriasis undergoing NB-UVB therapy. Downregulation of Th17 signaling pathway was observed during NB-UVB therapy in psoriatic epidermis. Strong inhibition of the Th17 pathway by UVB was confirmed in an ex vivo organ culture system by demonstrating reduced signal transducer and activator of transcription 3 (STAT3) phosphorylation and -defensin-2 production. These results were further substantiated by demonstrating that NB-UVB inhibited the Th17-dependent psoriasis-like dermatitis in mice. Other pathways affected by NB-UVB therapy include the IFN signaling pathway, epidermal differentiation, | + | ===== Other treatments |
- | </ | + | |
- | ===== Evidence of infectious cause ===== | + | |
+ | For many physicians, immunosuppressive medications are a first-line treatment for psoriasis. These drugs suppress the innate immune response, which provides some patients with temporary symptom palliation, because they reduce immunopathology, | ||
- | Superantigens(({{pubmed> | + | * **corticosteroids** – For even short periods of time, steroid use can become genuinely addictive. Research shows that any kind of short-term symptomatic improvement from corticosteroid use does not last, and that over the longer term, use of the drugs entales a litany of side effects. For their own safety, patients on the Marshall Protocol (MP) must [[home: |
+ | * **TNF-alpha inhibitors** – Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance.(({{pubmed> | ||
+ | * **methotrexate** – Methotrexate (MTX) is an antibiotic that interferes with bacteria' | ||
+ | * **[[home: | ||
- | microorganisms and psoriasis(({{pubmed> | ||
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- | (({{pubmed> | ||
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===== Patient interviews | ===== Patient interviews | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
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- | * legacy content | ||
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===== References ===== | ===== References ===== |