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--- home:diseases:psoriasis [08.30.2012] – paulalbert
+++ home:diseases:psoriasis [08.30.2012] – paulalbert
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-<IncompleteNotice>
 ====== Psoriasis ======
-Psoriasis is an autoimmune disease that affects the skin that varies in severity from minor localized patches to complete body coverage.
+Psoriasis is an autoimmune disease that affects the skin that varies in severity from minor localized patches to complete body coverage. The richness of the skin microbiome and the emerging discrepancies between the microbial composition between health and disease point to a microbial etiology for psoriasis.
 The Marshall Protocol treats psoriasis by reactivating the innate immune response. In the course of treatment, patients' disease symptoms may become worse due to a process called immunopathology.
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   * **cell wall deficient bacteria** – In a 2009 study, Wang investigated the carriage rate of cell wall deficient bacteria in the tonsil or pharynx of psoriasis patients. Cell wall deficient bacteria, a term often used interchangeably with l-form, were isolated from 74.2% of psoriasis patients, 23.5% of chronic tonsillitis patients and only 6.3% of controls.(({{pubmed>long:20137493}}))
-  * **differences in microbiota between psoriasis and normal skin** – A 2008 study of psoriatic skin not only found 84 novel species never before known to persist in skin, but also double the proportion of microbes from the //Firmicutes// phylum in psoriatic patients, as compared to healthy controls.(({{pubmed>long:18648509}})) This work has been partially replicated by Fahlén, whose group analyzed 10 patients using pyrosequencing,(({{pubmed>long:22065152}})) finding lower levels of //Propionibacterium//
+  * **differences in microbiota between psoriasis and normal skin** – A 2008 study of psoriatic skin not only found 84 novel species never before known to persist in skin, but also double the proportion of microbes from the //Firmicutes// phylum in psoriatic patients, as compared to healthy controls.(({{pubmed>long:18648509}})) In contrast, Fahlén's study analyzed 10 psoriatic patients using pyrosequencing,(({{pubmed>long:22065152}})) finding no difference in levels of Firmicutes but confirmed lower levels of //Propionibacterium//. The discrepancies between these two studies illustrate the importance of focusing on the [[home:pathogenesis:microbiota#effect_of_bacteria_on_their_human_host|activity of microbes]] and as well as the competence of the immune response.
+  * **bacterial DNA in blood of psoriatic patients** – Peripheral blood samples from 20 patients with psoriasis and from 16 control subjects were studied for the presence of bacteria by PCR using universal 16S ribosomal DNA primers and specific primers for S. pyogenes. Sequence analysis of amplified 16S rRNA sequences was used to determine taxonomic identity. Ribosomal bacterial DNA was detected in the blood of all 20 patients with psoriasis, but in none of the controls.(({{pubmed>long:20607546}}))
-Superantigens(({{pubmed>long:11040420}}))
-microorganisms and psoriasis(({{pubmed>long:8040907}}))
-(({{pubmed>long:18648509}}))
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-{{tag>diseases incomplete}}
+{{tag>diseases}}
 ===== Notes and comments =====

home/diseases/psoriasis.txt · Last modified: 09.14.2022 by 127.0.0.1