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home:diseases:psoriasis [08.30.2012] – paulalbert | home:diseases:psoriasis [09.14.2022] (current) – external edit 127.0.0.1 | ||
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====== Psoriasis ====== | ====== Psoriasis ====== | ||
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Psoriasis is an autoimmune disease that affects the skin that varies in severity from minor localized patches to complete body coverage. The richness of the skin microbiome and the emerging discrepancies between the microbial composition between health and disease point to a microbial etiology for psoriasis. | Psoriasis is an autoimmune disease that affects the skin that varies in severity from minor localized patches to complete body coverage. The richness of the skin microbiome and the emerging discrepancies between the microbial composition between health and disease point to a microbial etiology for psoriasis. | ||
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===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
- | * **cell wall deficient bacteria** – In a 2009 study, Wang investigated the carriage rate of cell wall deficient bacteria in the tonsil or pharynx of psoriasis patients. Cell wall deficient bacteria, a term often used interchangeably with l-form, were isolated from 74.2% of psoriasis patients, 23.5% of chronic tonsillitis patients and only 6.3% of controls.(({{pubmed> | + | * **cell wall deficient bacteria** – In a 2009 study, Wang investigated the carriage rate of cell wall deficient bacteria in the tonsil or pharynx of psoriasis patients. Cell wall deficient bacteria, a term often used interchangeably with l-form, were isolated from 74.2% of psoriasis patients, 23.5% of chronic tonsillitis patients and only 6.3% of controls.(({{pmid> |
- | * **differences in microbiota between psoriasis and normal skin** – A 2008 study of psoriatic skin not only found 84 novel species never before known to persist in skin, but also double the proportion of microbes from the // | + | * **differences in microbiota between psoriasis and normal skin** – A 2008 study of psoriatic skin not only found 84 novel species never before known to persist in skin, but also double the proportion of microbes from the // |
- | * **bacterial DNA in blood of psoriatic patients** – Peripheral blood samples from 20 patients with psoriasis and from 16 control subjects were studied for the presence of bacteria by PCR using universal 16S ribosomal DNA primers and specific primers for S. pyogenes. Sequence analysis of amplified 16S rRNA sequences was used to determine taxonomic identity. Ribosomal bacterial DNA was detected in the blood of all 20 patients with psoriasis, but in none of the controls.(({{pubmed> | + | * **bacterial DNA in blood of psoriatic patients** – Peripheral blood samples from 20 patients with psoriasis and from 16 control subjects were studied for the presence of bacteria by PCR using universal 16S ribosomal DNA primers and specific primers for S. pyogenes. Sequence analysis of amplified 16S rRNA sequences was used to determine taxonomic identity. Ribosomal bacterial DNA was detected in the blood of all 20 patients with psoriasis, but in none of the controls.(({{pmid> |
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* **corticosteroids** – For even short periods of time, steroid use can become genuinely addictive. Research shows that any kind of short-term symptomatic improvement from corticosteroid use does not last, and that over the longer term, use of the drugs entales a litany of side effects. For their own safety, patients on the Marshall Protocol (MP) must [[home: | * **corticosteroids** – For even short periods of time, steroid use can become genuinely addictive. Research shows that any kind of short-term symptomatic improvement from corticosteroid use does not last, and that over the longer term, use of the drugs entales a litany of side effects. For their own safety, patients on the Marshall Protocol (MP) must [[home: | ||
- | * **TNF-alpha inhibitors** – Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance.(({{pubmed> | + | * **TNF-alpha inhibitors** – Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance.(({{pmid> |
* **methotrexate** – Methotrexate (MTX) is an antibiotic that interferes with bacteria' | * **methotrexate** – Methotrexate (MTX) is an antibiotic that interferes with bacteria' | ||
- | * **[[home: | + | * **[[home: |
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+ | ===== Research ===== | ||
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+ | ===== Patients experiences ===== | ||
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sarcoidosis, | sarcoidosis, | ||
- | Read the [[http:// | + | Read the [[https:// |
< | < | ||
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- | {{tag>diseases}} | + | {{tag>disease}} |
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
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- | ===== References ===== | + | ===== References =====</ |