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home:diseases:reactive_arthritis [10.17.2018] – [Evidence of infectious cause] sallieq | home:diseases:reactive_arthritis [01.15.2019] – [Notes and comments] sallieq | ||
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====== Reactive arthritis (Reiter' | ====== Reactive arthritis (Reiter' | ||
+ | ===== Introduction ===== | ||
[[http:// | [[http:// | ||
- | < | + | ===== Evidence of infectious cause ===== |
- | Chlamydia-induced ReA: immune imbalances and persistent pathogens. | + | |
- | Gracey E, Inman RD. | + | |
- | Source | + | < |
- | Toronto Western Hospital, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada. | + | |
- | Abstract | + | |
Reactive arthritis (ReA), an inflammatory arthritic condition that is commonly associated with Chlamydia infections, represents a significant health burden, yet is poorly understood. The enigma of this disease is reflected in its problematic name and in its ill-defined pathogenesis. The existence of persistent pathogens in the arthritic joint is acknowledged, | Reactive arthritis (ReA), an inflammatory arthritic condition that is commonly associated with Chlamydia infections, represents a significant health burden, yet is poorly understood. The enigma of this disease is reflected in its problematic name and in its ill-defined pathogenesis. The existence of persistent pathogens in the arthritic joint is acknowledged, | ||
</ | </ | ||
+ | Combination antibiotics for Chlamydia-induced arthritis: breakthrough to a cure? (({{pubmed> | ||
+ | Editorial | ||
+ | Reactive arthritis (ReA) and its association with an extra-articular bacterial infection have first been described almost a century ago. From the view of the entry site of the pathogen, there is a post-urethritic and a post-dysenteric ReA form mainly caused by Chlamydia trachomatis and Enterobacteria (such as Yersinia, Salmonella, or Shigella), respectively. In addition, numerous other but less frequent organisms have been implicated in ReA, including Chlamydophila pneumoniae causing respiratory tract infections at the primary site. | ||
- | Arthritis Rheum. 2010 May; | + | In order to cause ReA, a pathogen must be specifically equipped, i.e. it needs to be an obligate or facultative intracellular organism, travel from mucosal surfaces to the joint, modify its metabolic state in order to evade the host defense mechanism, and survive as a persistent agent. Given all this, Chlamydia trachomatis is the best studied pathogen. This is also because epidemiological work has established this pathogen as the most common organism leading to ReA in the course of a urogenital infection. |
- | Combination antibiotics for Chlamydia-induced arthritis: breakthrough | + | |
- | Rihl M, Kuipers JG, Köhler L, Zeidler H. | + | |
- | Comment on: | + | |
- | Arthritis Rheum. 2010 May; | + | |
- | Editorial | ||
- | Reactive arthritis (ReA) and its association with an extra-articular bacterial infection have first been described almost a century ago. From the view of the entry site of the pathogen, there is a post-urethritic and a post-dysenteric ReA form mainly caused by Chlamydia trachomatis and Enterobacteria (such as Yersinia, Salmonella, or Shigella), respectively. In addition, numerous other but less frequent organisms have been implicated in ReA, including Chlamydophila pneumoniae causing respiratory tract infections at the primary site (1). | ||
- | In order to cause ReA, a pathogen must be specifically equipped, i.e. it needs to be an obligate or facultative intracellular organism, travel from mucosal surfaces to the joint, modify its metabolic state in order to evade the host defense mechanism, and survive | + | " |
+ | BACKGROUND:: | ||
- | Jd, C., E. Lr, et al. (2010). " | + | METHODS:: This study was a 9-month, double-blind, triple-dummy prospective trial assessing a 6-month course of combination |
- | BACKGROUND:: | + | RESULTS:: 80 subjects were screened and 42 were randomized to treatment (27 to combination antibiotics and 15 to placebo). Subjects in each group had similar demographics and baseline characteristics. At month 6, 17/27 subjects (63%) randomized to combination antibiotics were responders compared to 3/15 (20%) on placebo (P-value = 0.01). Secondary efficacy endpoints showed similar results with significant improvement in the modified swollen joint count, tender joint count, physician global assessment (P-values 0.0007, 0.002, and 0.0009, respectively), |
- | ===== Evidence | + | CONCLUSION:: |
- | Sample PubMed cite(({{pubmed> | + | ===== Patient information ===== |
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- | {{tag> | + | {{tag> |
- | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
+ | |||
+ | My diagnosis was Reiter' | ||
+ | |||
+ | Starting | ||
+ | Have some pain in my back behind heart has been there for weeks at least also pain in centre of chest severity varies but has improved markedly since wearing noirs and avoiding sun and light,also changing diet, | ||
+ | |||
+ | Day 9 | ||
+ | The pain in front of my chest has decreased about 40%,still got pain in the back on both sides of the spine(but decreased)seem to sweat easily,no headache, | ||
+ | |||
+ | Day 15 | ||
+ | | ||
+ | |||
+ | This dosing of benicar seens to have helped a lot | ||
+ | |||
+ | Day 17 | ||
+ | Had a very painful night last night,the pain in the left of my neck diminished about 80%,still had some pain on left side of neck just above collar bone but at rear of neck,had breathtaking pain on right side of neck at the base of my scull,could not lift my head had to lift my head physically with my hands, | ||
+ | |||
+ | Day 19 I spoke too soon about the pain,it came back with a vengeance last night,did not sleep all night,it is strange that most of my pain is on my left side,and this is the side which was first involved with my Reiter' | ||
+ | |||
+ | April | ||
+ | The pain has decreased a lot,neck still quite sore(acute pain)am doing all i can to stabilise my condition, | ||
+ | |||
+ | Day 27 | ||
+ | Had a fairly restless night, | ||
+ | |||
+ | Day 29 BENICAR | ||
+ | had a lot of pain in my left foot and left knee saturday might ,they are both playing up quite a bit lately,but on the other hand i have had a lot of relief in my upper torso,far outweighs any pain in my foot or knee,the knee is at about 8/10 in the pain leval (very sharp pain in the front centre)my left foot is also very painfull to put weight on,the fire in my chest has gone out but the skin is still sensative to touch,still have some pain in my lungs,and neck (reduced)but this did get *very*painfull last night(sun)when i left mino 30hrs,left hip varies in intensity ,but i am sure if i left mino this would flare up | ||
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+ | $$$$$ | ||
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+ | possible content https:// | ||
+ | Text**, | ||
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