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home:diseases:reactive_arthritis [01.05.2019] – [Notes and comments] sallieq | home:diseases:reactive_arthritis [01.15.2019] – [Notes and comments] sallieq | ||
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- | Chlamydia-induced ReA: immune imbalances and persistent pathogens. | + | |
- | Gracey E, Inman RD. | + | |
- | Source | + | |
- | Toronto Western Hospital, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada. | + | |
- | Abstract | + | |
Reactive arthritis (ReA), an inflammatory arthritic condition that is commonly associated with Chlamydia infections, represents a significant health burden, yet is poorly understood. The enigma of this disease is reflected in its problematic name and in its ill-defined pathogenesis. The existence of persistent pathogens in the arthritic joint is acknowledged, | Reactive arthritis (ReA), an inflammatory arthritic condition that is commonly associated with Chlamydia infections, represents a significant health burden, yet is poorly understood. The enigma of this disease is reflected in its problematic name and in its ill-defined pathogenesis. The existence of persistent pathogens in the arthritic joint is acknowledged, | ||
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+ | Combination antibiotics for Chlamydia-induced arthritis: breakthrough to a cure? (({{pubmed> | ||
+ | Editorial | ||
+ | Reactive arthritis (ReA) and its association with an extra-articular bacterial infection have first been described almost a century ago. From the view of the entry site of the pathogen, there is a post-urethritic and a post-dysenteric ReA form mainly caused by Chlamydia trachomatis and Enterobacteria (such as Yersinia, Salmonella, or Shigella), respectively. In addition, numerous other but less frequent organisms have been implicated in ReA, including Chlamydophila pneumoniae causing respiratory tract infections at the primary site. | ||
- | Arthritis Rheum. 2010 May; | + | In order to cause ReA, a pathogen must be specifically equipped, i.e. it needs to be an obligate or facultative intracellular organism, travel from mucosal surfaces to the joint, modify its metabolic state in order to evade the host defense mechanism, and survive as a persistent agent. Given all this, Chlamydia trachomatis is the best studied pathogen. This is also because epidemiological work has established this pathogen as the most common organism leading to ReA in the course of a urogenital infection. |
- | Combination antibiotics for Chlamydia-induced arthritis: breakthrough | + | |
- | Rihl M, Kuipers JG, Köhler L, Zeidler H. | + | |
- | Comment on: | + | |
- | Arthritis Rheum. 2010 May; | + | |
- | Editorial | ||
- | Reactive arthritis (ReA) and its association with an extra-articular bacterial infection have first been described almost a century ago. From the view of the entry site of the pathogen, there is a post-urethritic and a post-dysenteric ReA form mainly caused by Chlamydia trachomatis and Enterobacteria (such as Yersinia, Salmonella, or Shigella), respectively. In addition, numerous other but less frequent organisms have been implicated in ReA, including Chlamydophila pneumoniae causing respiratory tract infections at the primary site (1). | ||
- | In order to cause ReA, a pathogen must be specifically equipped, i.e. it needs to be an obligate or facultative intracellular organism, travel from mucosal surfaces to the joint, modify its metabolic state in order to evade the host defense mechanism, and survive | + | " |
+ | BACKGROUND:: | ||
- | Jd, C., E. Lr, et al. (2010). " | + | METHODS:: This study was a 9-month, double-blind, triple-dummy prospective trial assessing a 6-month course of combination |
- | BACKGROUND:: | + | RESULTS:: 80 subjects were screened and 42 were randomized to treatment (27 to combination antibiotics and 15 to placebo). Subjects in each group had similar demographics and baseline characteristics. At month 6, 17/27 subjects (63%) randomized to combination antibiotics were responders compared to 3/15 (20%) on placebo (P-value = 0.01). Secondary efficacy endpoints showed similar results with significant improvement in the modified swollen joint count, tender joint count, physician global assessment (P-values 0.0007, 0.002, and 0.0009, respectively), |
- | ===== Evidence | + | CONCLUSION:: |
- | Sample PubMed cite(({{pubmed> | + | ===== Patient information ===== |
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- | {{tag> | + | {{tag> |
- | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | possible content https:// | + | My diagnosis was Reiter' |
+ | |||
+ | Starting | ||
+ | Have some pain in my back behind heart has been there for weeks at least also pain in centre of chest severity varies but has improved markedly since wearing noirs and avoiding sun and light,also changing diet, | ||
+ | |||
+ | Day 9 | ||
+ | The pain in front of my chest has decreased about 40%,still got pain in the back on both sides of the spine(but decreased)seem to sweat easily,no headache, | ||
+ | |||
+ | Day 15 | ||
+ | | ||
+ | |||
+ | This dosing of benicar seens to have helped a lot | ||
+ | |||
+ | Day 17 | ||
+ | Had a very painful night last night,the pain in the left of my neck diminished about 80%,still had some pain on left side of neck just above collar bone but at rear of neck,had breathtaking pain on right side of neck at the base of my scull,could not lift my head had to lift my head physically with my hands, | ||
+ | |||
+ | Day 19 I spoke too soon about the pain,it came back with a vengeance last night,did not sleep all night,it is strange that most of my pain is on my left side,and this is the side which was first involved with my Reiter' | ||
+ | |||
+ | April | ||
+ | The pain has decreased a lot,neck still quite sore(acute pain)am doing all i can to stabilise my condition, | ||
+ | |||
+ | Day 27 | ||
+ | Had a fairly restless night, | ||
+ | |||
+ | Day 29 BENICAR | ||
+ | had a lot of pain in my left foot and left knee saturday might ,they are both playing up quite a bit lately,but on the other hand i have had a lot of relief in my upper torso,far outweighs any pain in my foot or knee,the knee is at about 8/10 in the pain leval (very sharp pain in the front centre)my left foot is also very painfull to put weight on,the fire in my chest has gone out but the skin is still sensative to touch,still have some pain in my lungs,and neck (reduced)but this did get *very*painfull last night(sun)when i left mino 30hrs,left hip varies in intensity ,but i am sure if i left mino this would flare up | ||
+ | |||
+ | Apr 18th, 2005 | ||
+ | NECK pain 90% gone (like heaven)am able to sleep,my left foot has been " | ||
+ | |||
+ | May 10th | ||
+ | Have had another day of the same,no let up in pain in my foot,was quite comfortable last night but had 100mg tramadol, | ||
+ | |||
+ | May 15th | ||
+ | Still having severe pain in my left foot (joints at the base of the toes)and also haff way down left side of foot (bone inside swolen)my left knee has varying amounts of pain, | ||
+ | |||
+ | |||
+ | May 30th | ||
+ | Have had the weekend at home,did not get any let up in symtoms, | ||
+ | |||
+ | June 14th | ||
+ | |||
+ | BEEN A FEW DAYS SINCE MY LAST REPORT,HAVE HAD SOME DIFFERENT SYMTOMS,THE PAIN IN MY LOWER SCULL ON BOTH SIDES INCREASED MARKEDLY,I ALSO HAD A RE OCCURANCE OF PAIN IN MY LEFT LUNG BEHIND MY SHOULDER BLADE,MY LEFT HIP AT THE FRONT ALSO WA TENDER, | ||
+ | |||
+ | Foundation Staff reply | ||
+ | Most meat has significant quantities of Vit D. It is in the feed supplements, | ||
+ | |||
+ | The flour in the roll may have been fortified with Folic Acid. | ||
+ | |||
+ | The sauce may have contained Monosodium Glutamate. | ||
+ | |||
+ | You may have had a pickle which had been processed with the coloring Yellow #5 (E103) | ||
+ | |||
+ | July 5th | ||
+ | SINCE i last posted | ||
+ | |||
+ | August 29th | ||
+ | FOOT PAIN SEEMS TO HAVE REACHED A POINT WHERE IT IS NEITHER GETTING BETTER OR WORSE,STILL PAINFULL TO WALK BUT COMFORTABLE AT NIGHT,I HAVE STARTED CLINDY TODAY 33MG FIRST DOSE WILL KEEP YOU INFORMED WITH MY PROGRESS,I AM STILL HERXING IN MY RIGHT INDEX FINGER ALSO,MR WRIST SEEMS TO HAVE SETTLED, | ||
+ | |||
+ | September 24th | ||
+ | LAST WEEK I HAVE INTRODUCED QUERCETIN AND ALSO AM ALTERNATING MINOCIN AND AKAMIN (A GENERIC BRAND OF MINOCYCLIN AVAILABLE IN AUSTRALIA)I HAVE EXPERIENCED SOME SEVERE HERX SYMPTOMS IN MY BREAST BONE AREA ,A REPEAT OF EARLIER SYMTOMS WHEN I FIRST STARTED THE PROTOCOL,MY FOOT IS STILL QUITE SORE AS IS MY TAIL BONE AND INDEX FINGER R/HAND,I AM STILL VERY RESTLESS AT NIGHT AND MY BODY TEMP SEEMS QUITE HIGH ALL THE TIME,I ALSO STILL HAVE A TENDER SPOT ON THE CORNER OF MY HIP ,MY NECK AND SCULL PAIN SEEMS TO HAVE ALL BUT RESOLVED ITSELF,THE PAIN IN MY FOOT SEEMS TO BE MORE IN THE CENTRE AREA OF MY FOOT BETWEEN THE TOES AND MY ANKLE (THE MAIN BULKY AREA ,I SEEM TO BE EXPERIENCING MORE HERX SYMPTOMS SINCE INTRODUCING CLINDY AND POSSIBLY ALTERNATING BRANDS OF MINOCYCLINE, | ||
+ | |||
+ | October 10th | ||
+ | SYMPTOMS HAVE GENERALLY DETERIORATED, | ||
+ | |||
+ | 2006 Jan 17th | ||
+ | HAVE DEVELOPED SOME SORENESS IN THE LOWER SECTION OF MY SPINE ABOUT 1/3 OF THE WAY UP VERY TENDER TO PUSH ON,MY COXIC BONE SORENESS HAS DECREASED TO THE POINT IT IS BARELY NOTICABLE, | ||
+ | |||
+ | Jan 30th NOT MUCH NEW HAPPENING AT THE MOMENT,LEFT FOOT STILL IMPROVING, | ||
+ | |||
+ | WILL BE INCREASING MY CLINDY TO 150MG Q48HR TOMORROW FOR THE NEXT COUPLE OF MONTHS, | ||
+ | |||
+ | Jun 22nd, | ||
+ | PSHED MYSELF A BIT TOO MUCH AT WORK I THINK,BODY IS HAVING ENOUGH TROUBLE CPING WITH PROTOCOL ET ALONE WORK 70TO 80 HRS A WEEK,GOT A BIT TOO MUCH,ANY WAY FEELNG A BIT BETTER NOW,GETTING PAIN IN MY KIDNEY AREA ON BOTH SDES FROM TIME TO TMESEEMS TO ALTERNATE, | ||
+ | |||
+ | October 13th | ||
+ | STILL GOT MY COLD,CAME BACK AGAIN AND SEEMS TO BE TAPERING OFF AGAIN ,BACTRIM SEEMED TO AGRAVATE MY COLD,SEEM TO BE FELING A BIT BETTER SINCE STOPPING BACTRIM AND CLINDY, | ||
+ | |||
+ | WENT TO THE SKIN CANCER CLINIC AND HE HAS DIAGNOSED THE SMALL LESION THAT I HAVE BEEN COMPLAINING ABOUT AS A CANCER AND WILL BE REMOVING IT AND TAKING A GRAFT FROM MY SHOULDER IN A COUPLE OF WEEKS TO FILL THE HOLE | ||
+ | |||
+ | October 28th | ||
+ | HAVE BEEN TO REMOVE CANCER ON THURSDAY, | ||
+ | |||
+ | December 2nd | ||
+ | I AM STILL EXPERIENCING LOWER INTESTINAL CRAMPS ,THE SLIGHTEST STRESS OR EXERTION SEEMS TO BRING ON AN ATTACK,HAVE HAD 5 DAYS OF THIS, | ||
+ | |||
+ | MEDS MINO 100MG Q48HR BENICAR | ||
+ | |||
+ | SX RIGHT KNEE HAS VERY SHARP PAIN INSIDE, | ||
+ | |||
+ | 2007 | ||
+ | February 17th | ||
+ | NOTICING | ||
+ | |||
+ | |||
+ | MEDS BENICAR 40MG Q6HR ZITHROMAX 1/8 500 MG TAB Q 11DAYS MINOCIN 100MG 48HR CLINDY 65. MG Q48H | ||
+ | |||
+ | CYCLE 17 day 3 | ||
+ | Am experiencing pain in left kidney towards front,and right kidney at rear,had a lot of pain in my right shoulder blade area last night,some pain in the front of my chest, | ||
+ | |||
+ | March 24th | ||
+ | herx reaction at the moment seems to be quite moderate, | ||
+ | |||
+ | Have not reported this before but i seem to be growing hair on my head WHERE NONE HAS EXISTED FOR QUITE SOME TIME,I HEARD the protocol made you feel young again but did not expect this | ||
+ | |||
+ | |||
+ | May 28 | ||
+ | Have had A FAIR AMOUNT OF ITCHING LATELYLEFT SHOLDER STILL TRYING T SEIZE IF NOT WORKED,HAVE BEEN GETTING SOME SIMLAR PAIN IN MY RIGHT ARM AND ELBOW,LOWER LUNGARA BOTH SIDES SIL SORE,WAS COMPLETELY STUFFED ON SATURDAY (DAY 6)HAD TO HAVE A NAP IN THE AFTERNOON COULD NOT CONTINUE TO FUNCTION, | ||
+ | |||
+ | July 19 | ||
+ | MEDS BENICAR 40MG Q6HR ZITHROMAX 3/16 500 MG TAB Q 11DAYS MINOCIN 100MG 48HR CLINDY 112. MG Q48H | ||
+ | |||
+ | CYCLE 30 day2 | ||
+ | Have ceased official work 1.5 weeks now,good to have some time to myself,have started swimming again lately (when sun goes down)need to keep motivated, | ||
+ | |||
+ | Just a short note,have been eating some yoghurts lately and they seem to have had an adverse effect on me ,had unbearable pain behind my hear last night,had to take some quarterzone to relieve pain,also took tramal and panadole,i recall this has also happened in the past but i thought i would possibly be o.k at this stage (lucky i had some prednisalone as io could not bear the pain it was so intense | ||
+ | |||
+ | 2008 April | ||
+ | |||
+ | just a short note,i went to my surgeon that repaired my broken knee 5 years ago to book in for surgery to remove two titanium plates in my leg,i particularly ASKED HIS OPINION on the amount of arthritis present at the site of the multiple fracture he repaired,he said he would have expected to see a lot of arthritis at the site but was pleased to see there was very little if any arthritis at my knee joint,my ankle which was also fractured at the time and went un noticed untill about 3 months after my knee repair has obvious sighns of arthritis at the fracture site ,so a bit of a mixed bag,no arthritis at knee but arthritis obviously evident at ankle | ||
+ | |||
+ | 2009 January | ||
+ | have been off demi and zith a few days now,have noticed a 80% improvment in the pain in my left hip(all but gone)looks like this was herx,also seems to be some improvement in the pain in the front of my groin,which was at the sight of my hernia i had repaired last year,anyway at this time only positive pain improvement, | ||
+ | |||
+ | (@4 yrs 10 months on MP) i survived the operation, | ||
+ | |||
+ | I questioned Doc regarding evidence of arthritis at the location of the plates and pins and he told me there was none,(on my previous visit to see him he had told me that even though no arthritis was evident on the x rays ,he was fairly certain this would not be the case when the plates were removed)surprise for him ,but he did not make much of it | ||
+ | |||
+ | As for the condition of my bones,i did specifically ask him to pay attention to the condition of them and if he found them fragile or unusual in regards to the noem,again he commented all seemed good | ||
+ | |||
+ | Jan 23rd, 2009 have been out of hospital 7 days now,added demi back two days ago,no adverse herx,added zith back today ,will let you know how it goes,am seeing chiro again today, | ||
+ | |||
+ | May 10th | ||
+ | ,removing zith and bactrim has decreased herx to a large degree, | ||
+ | |||
+ | ,seem to have my old knee 95% back at the moment it realy feels great, | ||
+ | |||
+ | My local Gp has finally expressed interest in the protocoll and is gointg to have a look at the prague conference dvd | ||
+ | |||
+ | June 9 | ||
+ | my lungs were on fire and the tablets seem to have helped,my last cold last year also ended up being a long saga(MONTHS)and i was dreading this year,the only difference between this year and last year is that if anything i have more sun exposure this time | ||
+ | |||
+ | I think i would be hospitolised if i did nothing,i did take Benicar sub lingual on quite a few occasions as well as q4hrs and made no difference ,just seemed to be getting worse and coughing up discusting green flem,will see my doc when i get home | ||
+ | |||
+ | Colds have never been a problem for me before ,and last about 2 weeks as you say,i felt this one coming on three weeks befor i left on my trip,went on a outing to the city ,and on the way back felt the familiar irritation at the back of my throat,and that was it | ||
+ | |||
+ | Resorted TO Tamiflu as anti biotics were not an option, | ||
+ | |||
+ | Sept 14 | ||
+ | Just a short note, have been experiencing some pain in my upper back and lung area 6/10 , also quite a lot of pain in my kidney area radiating across to both sides of my lower back 6/10,seems to reduce when i get up and about , and increases when i am less active at night, still have some phlem problem , but not interfering with exercise regime , swimming alternate days and walking also , herx seems to be increasing since stopping Mino | ||
+ | |||
+ | 2010 | ||
+ | Feb | ||
+ | Seem to be having massive herx ,may have introduced zith at too high a leva | ||
+ | |||
+ | Sept | ||
+ | Am still experiencing quite a lot of lower back pain7/ | ||
+ | |||
+ | Nov | ||
+ | sun has not been effecting me anywhere near as much as it used to,going out again this morning, | ||
+ | |||
+ | Don't think hospital will be necessary now,if things keep improving as they have been,it realy has been eye opener this Nutrition exercise,it all started when i started looking for treatment for my Brothers lung Cancer,and came to realise LACK OF NUTRITIONAL Minerals combined wit the TOXIC Chemicals we consume play a massive part in this disease process also | ||
+ | |||
+ | Lungs are still a problem ,but the back looks like it may be OK | ||
+ | |||
+ | 2011 | ||
+ | Jan Benicar 20mg q8hr Minocin 100mg q72hrs | ||
+ | ,lower back pain has decreased significantly with the use of Sulphur /MSM ,CAN NOT BELIEVE THE DIFFERENCE THIS HAS MADE,AM KAYAKING TWICE A WEEK NOW EARLY MORNINGS FOR APPROX 1.5 HRS EACH DAY ,ABOUT 8K-10 KLM ,I WOULD HAVE NEVER BELIEVED THIS 2 MONTHS AGO , MY FEET ARE STILL GETTING HOT, LUNG INFEVTION ALL BUT GONSun sensativity minimal,not reacting as i used to ,paddle early morings in daylight ,6am to 7.30am ,but no negative noticable herx,wear noirs and protective clothing, | ||
+ | |||
+ | Feb | ||
+ | have decided to up Benicar back to 40mg q8hr , at this early stage it seems to have had some effect on lessening burning feet problem. | ||
+ | |||
+ | |||
+ | |||
+ | //(page 39 done)// | ||
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+ | $$$$$ | ||
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+ | possible content https:// | ||
+ | Text**, | ||
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