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home:diseases:rheumatoid_arthritis [07.10.2019]
sallieq [Gout]
home:diseases:rheumatoid_arthritis [07.10.2019]
sallieq [Gout]
Line 202: Line 202:
 //​David//</​blockquote>​ //​David//</​blockquote>​
  
-Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. The relationship remains significant after adjustment for several confounders,​ including age, sex, adiposity, anti-hypertensive treatments or diuretics use. To confirm the existence of a causal relationship,​ we examined the effect of UA on the expression of inflammatory biomarkers in human hepatoma HepG2 cells and characterized the signaling pathway by which UA acts. +Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. The relationship remains significant after adjustment for several confounders,​ including age, sex, adiposity, anti-hypertensive treatments or diuretics use. To confirm the existence of a causal relationship,​ we examined the effect of UA on the expression of inflammatory biomarkers in human hepatoma HepG2 cells and characterized the signaling pathway by which UA acts.  ​.......The effect of UA was completely blocked by the antioxidant N-acetylcysteine. ​ (({{pubmed>​long:​28408375}}))
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-The effect of UA was completely blocked by the antioxidant N-acetylcysteine. +
-(({{pubmed>​long:​28408375}}))+
  
  
home/diseases/rheumatoid_arthritis.txt · Last modified: 07.14.2019 by sallieq
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