You are here: Welcome to the MPKB » Welcome to the MPKB » Diseases » Arthritis
Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
Last revisionBoth sides next revision
home:diseases:rheumatoid_arthritis [07.10.2019] – [Gout] sallieqhome:diseases:rheumatoid_arthritis [07.14.2019] – [Development during IRIS] sallieq
Line 62: Line 62:
 ==== Development during IRIS ==== ==== Development during IRIS ====
  
-During IRIS, HIV/AIDS patients experience the worsening or onset of systemic inflammatory clinical signs and symptoms following treatment with highly active antiretroviral therapy (HAART). This syndrome results when HAART allows for partial recovery of the immune response. This causes renewed and exuberant host immunological responses towards opportunistic infectious agents, agents that the host accumulated during prior periods of immunosuppression.(({{pubmed>long:20507930}}))+During immune reconstitution inflammatory syndrome, HIV/AIDS patients experience the worsening or onset of systemic inflammatory clinical signs and symptoms following treatment with highly active antiretroviral therapy (HAART). This syndrome results when HAART allows for partial recovery of the immune response. This causes renewed and exuberant host immunological responses towards opportunistic infectious agents, agents that the host accumulated during prior periods of immunosuppression.(({{pubmed>long:20507930}}))
  
 A number of well-known readily cultured pathogens have been conclusively linked to IRIS: the herpes viruses, cytomegalovirus, hepatitis B and C, //M. tuberculosis//, //Mycobacterium avium// complex and //Cryptococcus neoformans//.(({{pubmed>long:17488505}})) However, many more microbes likely contribute to the reaction since AIDS clinicians do not yet have access to the metagenomic tools. Certainly, the existence of IRIS in culture-negative HAART patients suggests that more microbes may be present than the few that have already been isolated.(({{pubmed>long:19365271}})) A number of well-known readily cultured pathogens have been conclusively linked to IRIS: the herpes viruses, cytomegalovirus, hepatitis B and C, //M. tuberculosis//, //Mycobacterium avium// complex and //Cryptococcus neoformans//.(({{pubmed>long:17488505}})) However, many more microbes likely contribute to the reaction since AIDS clinicians do not yet have access to the metagenomic tools. Certainly, the existence of IRIS in culture-negative HAART patients suggests that more microbes may be present than the few that have already been isolated.(({{pubmed>long:19365271}}))
Line 202: Line 202:
 //David//</blockquote> //David//</blockquote>
  
-Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. The relationship remains significant after adjustment for several confounders, including age, sex, adiposity, anti-hypertensive treatments or diuretics use. To confirm the existence of a causal relationship, we examined the effect of UA on the expression of inflammatory biomarkers in human hepatoma HepG2 cells and characterized the signaling pathway by which UA acts. +Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. The relationship remains significant after adjustment for several confounders, including age, sex, adiposity, anti-hypertensive treatments or diuretics use. To confirm the existence of a causal relationship, we examined the effect of UA on the expression of inflammatory biomarkers in human hepatoma HepG2 cells and characterized the signaling pathway by which UA acts.  .......The effect of UA was completely blocked by the antioxidant N-acetylcysteine.  (({{pubmed>long:28408375}}))
- +
-The effect of UA was completely blocked by the antioxidant N-acetylcysteine. +
-(({{pubmed>long:28408375}}))+
  
  
home/diseases/rheumatoid_arthritis.txt · Last modified: 09.14.2022 by 127.0.0.1
© 2015, Autoimmunity Research Foundation. All Rights Reserved.