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home:diseases:rheumatoid_arthritis [07.10.2019]
sallieq [Gout]
home:diseases:rheumatoid_arthritis [07.14.2019]
sallieq [Development during IRIS]
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 ==== Development during IRIS ==== ==== Development during IRIS ====
  
-During ​IRIS, HIV/AIDS patients experience the worsening or onset of systemic inflammatory clinical signs and symptoms following treatment with highly active antiretroviral therapy (HAART). This syndrome results when HAART allows for partial recovery of the immune response. This causes renewed and exuberant host immunological responses towards opportunistic infectious agents, agents that the host accumulated during prior periods of immunosuppression.(({{pubmed>​long:​20507930}}))+During ​immune reconstitution inflammatory syndrome, HIV/AIDS patients experience the worsening or onset of systemic inflammatory clinical signs and symptoms following treatment with highly active antiretroviral therapy (HAART). This syndrome results when HAART allows for partial recovery of the immune response. This causes renewed and exuberant host immunological responses towards opportunistic infectious agents, agents that the host accumulated during prior periods of immunosuppression.(({{pubmed>​long:​20507930}}))
  
 A number of well-known readily cultured pathogens have been conclusively linked to IRIS: the herpes viruses, cytomegalovirus,​ hepatitis B and C, //M. tuberculosis//,​ //​Mycobacterium avium// complex and //​Cryptococcus neoformans//​.(({{pubmed>​long:​17488505}})) However, many more microbes likely contribute to the reaction since AIDS clinicians do not yet have access to the metagenomic tools. Certainly, the existence of IRIS in culture-negative HAART patients suggests that more microbes may be present than the few that have already been isolated.(({{pubmed>​long:​19365271}})) A number of well-known readily cultured pathogens have been conclusively linked to IRIS: the herpes viruses, cytomegalovirus,​ hepatitis B and C, //M. tuberculosis//,​ //​Mycobacterium avium// complex and //​Cryptococcus neoformans//​.(({{pubmed>​long:​17488505}})) However, many more microbes likely contribute to the reaction since AIDS clinicians do not yet have access to the metagenomic tools. Certainly, the existence of IRIS in culture-negative HAART patients suggests that more microbes may be present than the few that have already been isolated.(({{pubmed>​long:​19365271}}))
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 //​David//</​blockquote>​ //​David//</​blockquote>​
  
-Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. The relationship remains significant after adjustment for several confounders,​ including age, sex, adiposity, anti-hypertensive treatments or diuretics use. To confirm the existence of a causal relationship,​ we examined the effect of UA on the expression of inflammatory biomarkers in human hepatoma HepG2 cells and characterized the signaling pathway by which UA acts. +Herein, we report a positive relationship between serum UA and acute-phase reactants, such as high-sensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. The relationship remains significant after adjustment for several confounders,​ including age, sex, adiposity, anti-hypertensive treatments or diuretics use. To confirm the existence of a causal relationship,​ we examined the effect of UA on the expression of inflammatory biomarkers in human hepatoma HepG2 cells and characterized the signaling pathway by which UA acts.  ​.......The effect of UA was completely blocked by the antioxidant N-acetylcysteine. ​ (({{pubmed>​long:​28408375}}))
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-The effect of UA was completely blocked by the antioxidant N-acetylcysteine. +
-(({{pubmed>​long:​28408375}}))+
  
  
home/diseases/rheumatoid_arthritis.txt · Last modified: 07.14.2019 by sallieq
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