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home:diseases:sarcoidosis [12.27.2018] – [Autoimmune vs. immunosuppressed] sallieqhome:diseases:sarcoidosis [03.15.2019] – [Lung (pulmonary)] sallieq
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 Kanchwala //et al.// showed that patients with sarcoidosis expressed the antimicrobial peptide cathelicidin less than healthy subjects, and that sicker sarcoidosis patients expressed it least of all.((Kanchwala, A., B. Barna, et al. (2009). [[http://meeting.chestpubs.org/cgi/content/abstract/136/4/127S-a|Deficiencies of cathelicidin and vitamin D accompany disease severity in sarcoidosis]].)) Wiken //et al.// showed that there was a reduced TLR2 mRNA expression in patients with Lofgren's syndrome (a type of acute sarcoidosis).(({{pubmed>long:20813038}})) Note that TLR2 (which the Marshall Pathogenesis theorizes is downregulated in autoimmune disease states) is expressed by the VDR.  Kanchwala //et al.// showed that patients with sarcoidosis expressed the antimicrobial peptide cathelicidin less than healthy subjects, and that sicker sarcoidosis patients expressed it least of all.((Kanchwala, A., B. Barna, et al. (2009). [[http://meeting.chestpubs.org/cgi/content/abstract/136/4/127S-a|Deficiencies of cathelicidin and vitamin D accompany disease severity in sarcoidosis]].)) Wiken //et al.// showed that there was a reduced TLR2 mRNA expression in patients with Lofgren's syndrome (a type of acute sarcoidosis).(({{pubmed>long:20813038}})) Note that TLR2 (which the Marshall Pathogenesis theorizes is downregulated in autoimmune disease states) is expressed by the VDR. 
  
-===== Statistics =====+===== Data =====
  
 //from DJ in California//  //from DJ in California// 
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 I tried my best to be unbiased as I was expecting to see about a 20% improvement in health of members, or in other words a 20-25% success rate. I was intending to compare this to the 10% success rate I found done on the use of prednisone to treat Sarcoidosis. That double blind report shows that 10% treated with prednisone achieve remission. (BTW remission in Sarcoidosis as far as I can find out is measured rather subjectively)  I tried my best to be unbiased as I was expecting to see about a 20% improvement in health of members, or in other words a 20-25% success rate. I was intending to compare this to the 10% success rate I found done on the use of prednisone to treat Sarcoidosis. That double blind report shows that 10% treated with prednisone achieve remission. (BTW remission in Sarcoidosis as far as I can find out is measured rather subjectively) 
 +
 The following information is what I found:  The following information is what I found: 
 +
 Sarcoidosis: 236 members; 179 success; 25 no success; 32 unsure  Sarcoidosis: 236 members; 179 success; 25 no success; 32 unsure 
- 
-Other Th1 diseases: 184 members; 110 success; 30 no success 44 unsure  
  
  
 TOTALS: 864 members;573 report success; 119 report no success; and for 172 results are not clear.  TOTALS: 864 members;573 report success; 119 report no success; and for 172 results are not clear. 
 +
 SUCCESS RATES:  SUCCESS RATES: 
 Over all success rate 66.32% Over all unsuccessful 13.77% Over all unsure 19.91%  Over all success rate 66.32% Over all unsuccessful 13.77% Over all unsure 19.91% 
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   * **hyperinflation** – Hyperinflation is sometimes called “air trapping” and may be helped by measures such as [[http://www.olivija.com/exercise/|pursed lip breathing]]. Pursed lip breathing can help release air trapped in the lungs and can help relieve the feeling of shortness of breath, if it's due to hyperinflation. In some cases, supplemental oxygen might be useful in overcoming hyperinflation. This [[http://www.medscape.com/viewarticle/518312|Medscape article]] (registration required) discusses how supplemental oxygen facilitates lung emptying.   * **hyperinflation** – Hyperinflation is sometimes called “air trapping” and may be helped by measures such as [[http://www.olivija.com/exercise/|pursed lip breathing]]. Pursed lip breathing can help release air trapped in the lungs and can help relieve the feeling of shortness of breath, if it's due to hyperinflation. In some cases, supplemental oxygen might be useful in overcoming hyperinflation. This [[http://www.medscape.com/viewarticle/518312|Medscape article]] (registration required) discusses how supplemental oxygen facilitates lung emptying.
   * **obstructive lung disease** – It's a little-recognized fact that sarcoidosis can cause PFTs results to indicate obstructive lung disease (sarcoidosis is considered a restrictive lung disease). This is because chest lymph nodes may become so enlarged they compress airways and/or granulomas themselves may obstruct airways. [[http://www.mayoclinic.com/invoke.cfm?id=AN00759|This article]] explains the difference between restrictive and obstructive lung disease.    * **obstructive lung disease** – It's a little-recognized fact that sarcoidosis can cause PFTs results to indicate obstructive lung disease (sarcoidosis is considered a restrictive lung disease). This is because chest lymph nodes may become so enlarged they compress airways and/or granulomas themselves may obstruct airways. [[http://www.mayoclinic.com/invoke.cfm?id=AN00759|This article]] explains the difference between restrictive and obstructive lung disease. 
-  * **pulmonary fibrosis** –  Formation or development of fibrous connective tissue in the lungs. Also called scarring, the creation of collagen allows the body to encase pathogens which have been missed by the immune system. Symptoms of pulmonary fibrosis include shortness of breath, a chronic dry cough, and chest discomfort. The angiotensin blockade (put into place by olmesartan) inhibits the formation of new fibrotic tissue.+  * **pulmonary fibrosis** –  Formation or development of fibrous connective tissue in the lungs. Also called scarring, the creation of collagen allows the body to encase pathogens which have been missed by the immune system. Symptoms of pulmonary fibrosis include shortness of breath, a chronic dry cough, and chest discomfort. The angiotensin blockade (put into place by olmesartan) inhibits the formation of new fibrotic tissue. ALSO This study suggests that mast cells may contribute to the progression of pulmonary fibrosis.  (({{pubmed>long:    30808717}}))  
   * **pulmonary hypertension** – Abnormally high blood pressure in the  in the pulmonary artery, which connects the heart to the lungs. It makes the right side of the heart need to work harder than normal. PH is common in sarcoidosis.(({{pubmed>long:16227329}})) (({{pubmed>long:16198969}})) (({{pubmed>long:15863633}})) (({{pubmed>long:15449010}}))   * **pulmonary hypertension** – Abnormally high blood pressure in the  in the pulmonary artery, which connects the heart to the lungs. It makes the right side of the heart need to work harder than normal. PH is common in sarcoidosis.(({{pubmed>long:16227329}})) (({{pubmed>long:16198969}})) (({{pubmed>long:15863633}})) (({{pubmed>long:15449010}}))
  
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 The reported frequency of ocular manifestations for sarcoidosis varies according to the source and group studied, but may be as high as 70%.(({{pubmed>long:18021432}}))  In the eye, the common sites of involvement are the skin of eyelid, conjunctiva, uveal tract, retina, optic nerve and lacrimal gland.(({{pubmed>long:11217257}})) Common symptoms of ocular sarcoidosis include: The reported frequency of ocular manifestations for sarcoidosis varies according to the source and group studied, but may be as high as 70%.(({{pubmed>long:18021432}}))  In the eye, the common sites of involvement are the skin of eyelid, conjunctiva, uveal tract, retina, optic nerve and lacrimal gland.(({{pubmed>long:11217257}})) Common symptoms of ocular sarcoidosis include:
-  * uveitis – Swelling and irritation of the uvea, the middle layer of the eye. Most common is anterior uveitis, however, over a quarter of patients will have inflammation at the posterior of the eye, including retinitis pars planitis. according to the  [[http://www.clevelandclinic.org/eye/patient_info/uveitis.asp|Cleveland Clinic]], "Complications of uveitis may include glaucoma, cataract, abnormal blood vessel growth, fluid within the retina and vision loss."+  * uveitis – Swelling and irritation of the uvea, the middle layer of the eye. Most common is anterior uveitis, however, over a quarter of patients will have inflammation at the posterior of the eye, including retinitis pars planitis. according to the Cleveland Clinic, "Complications of uveitis may include glaucoma, cataract, abnormal blood vessel growth, fluid within the retina and vision loss."
   * Sjogren's (Sicca) – Sjogren's and sarcoidosis are both described in the standard literature as a collection of symptoms. Sjogren's is known to be related to diseases such as rheumatoid arthritis, sarcoidosis, lupus, scleroderma and polymyositis. Many sarcoidosis patients manifest the same symptoms as described in Sjogren's syndrome (dry eyes and mouth, decreased tears and saliva, and resulting dental caries). Sjogren's is reportedly seen in about half of patients.   * Sjogren's (Sicca) – Sjogren's and sarcoidosis are both described in the standard literature as a collection of symptoms. Sjogren's is known to be related to diseases such as rheumatoid arthritis, sarcoidosis, lupus, scleroderma and polymyositis. Many sarcoidosis patients manifest the same symptoms as described in Sjogren's syndrome (dry eyes and mouth, decreased tears and saliva, and resulting dental caries). Sjogren's is reportedly seen in about half of patients.
   * photosensitivity   * photosensitivity
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 huh ! link removed from gif huh ! link removed from gif
  Source: [[http://meeting.chestpubs.org/cgi/content/abstract/136/4/127S-a|Kanchwala et al.]]}}]  Source: [[http://meeting.chestpubs.org/cgi/content/abstract/136/4/127S-a|Kanchwala et al.]]}}]
 +
 +[[http://www.clevelandclinic.org/eye/patient_info/uveitis.asp|Cleveland Clinic]]
  
 smoking reduces risk smoking reduces risk
home/diseases/sarcoidosis.txt · Last modified: 09.14.2022 by 127.0.0.1
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