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home:diseases:schizophrenia [01.06.2019] – [Notes and comments] sallieq | home:diseases:schizophrenia [07.07.2019] – [Evidence of infectious cause] sallieq | ||
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+ | ===== Introduction ===== | ||
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===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
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* **Prenatal infection and schizophrenia** – According to Alan S. Brown of Columbia University, " | * **Prenatal infection and schizophrenia** – According to Alan S. Brown of Columbia University, " | ||
+ | * see also (({{pubmed> | ||
* **Increased suceptibility to other probable infectious diseases** - There is an increased prevalence of Sjogren' | * **Increased suceptibility to other probable infectious diseases** - There is an increased prevalence of Sjogren' | ||
==== More evidence ==== | ==== More evidence ==== | ||
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- | * [[http:// | ||
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</ | </ | ||
- | 2018 electron microscope study [[http:// | + | * [[http:// |
+ | * [[http:// | ||
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+ | Lithium and antidepressants: | ||
===== Schizophrenia tied to a range of autoimmune ills ===== | ===== Schizophrenia tied to a range of autoimmune ills ===== | ||
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"It would make sense that some of the genes are determinants of the response to infection." | "It would make sense that some of the genes are determinants of the response to infection." | ||
- | ====== Associated condition | + | ===== Associated condition ===== |
[[https:// | [[https:// | ||
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[[https:// | [[https:// | ||
+ | The short chain fatty acids (SCFA) acetate, butyrate, and propionate, major metabolites derived from fermentation of dietary fibers by gut microbes, interact with multiple immune and metabolic pathways. The specific pathways that SCFA are thought to target, are dysregulated in cardiovascular disease, type II diabetes, and systemic inflammation. Most notably, these disorders are consistently linked to an attenuated lifespan in schizophrenia. | ||
+ | < | ||
+ | The short chain fatty acids (SCFA) acetate, butyrate, and propionate, major metabolites derived from fermentation of dietary fibers by gut microbes, interact with multiple immune and metabolic pathways. The specific pathways that SCFA are thought to target, are dysregulated in cardiovascular disease, type II diabetes, and systemic inflammation. Most notably, these disorders are consistently linked to an attenuated lifespan in schizophrenia. | ||
- | ====== Impact of cannabis use ====== | + | |
+ | Although, the abovementioned studies demonstrate that SCFA are present in the brain and modify inflammation in a beneficial manner, administration of valproic acid, a medication commonly prescribed for symptoms associated with bipolar disorder and epilepsy, inhibits the transport of SCFA across the blood brain barrier in rodents (Adkison and Shen, 1996). In addition, in vitro studies reveal that free fatty acids in the intestine can have cytotoxic properties (Penn and Schmid-Schonbein, | ||
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+ | ===== Impact of cannabis use ===== | ||
Clinical epidemiological studies have indicated cannabis use to confer a 2-fold increase in risk for subsequent onset of psychosis, with adolescent-onset use conveying even higher risk(({{pubmed> | Clinical epidemiological studies have indicated cannabis use to confer a 2-fold increase in risk for subsequent onset of psychosis, with adolescent-onset use conveying even higher risk(({{pubmed> | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | This article is republished from Yale News. For questions, please contact Bill Hathaway at william.hathaway@yale.edu. | + | https:// |
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+ | (Scientists Find Roots of Neuropsychiatric Diseases)This article is republished from Yale News. For questions, please contact Bill Hathaway at william.hathaway@yale.edu. | ||
+ | see also | ||
+ | https:// | ||
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+ | https:// | ||
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+ | https:// | ||
< | < |