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home:diseases:schizophrenia [02.19.2019] – [Recent research] sallieq | home:diseases:schizophrenia [09.14.2022] (current) – external edit 127.0.0.1 | ||
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===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
- | - **Increased rate of schizophrenia for infants born during spring/ | + | - **Increased rate of schizophrenia for infants born during spring/ |
- | - **Co-infections** – persistent co-infections are generally a sign of an immune system disabled by the Th1 pathogens. It's telling to note that there remains no conclusive evidence for any single kind of virus or bacteria always present in patients with schizophrenia.(({{pubmed> | + | - **Co-infections** – persistent co-infections are generally a sign of an immune system disabled by the Th1 pathogens. It's telling to note that there remains no conclusive evidence for any single kind of virus or bacteria always present in patients with schizophrenia.(({{pmid> |
- | * Borna disease virus (({{pubmed> | + | * Borna disease virus (({{pmid> |
- | * // | + | * // |
- | * herpes simplex virus (({{pubmed> | + | * herpes simplex virus (({{pmid> |
- | * retroviruses (({{pubmed> | + | * retroviruses (({{pmid> |
- | * **Prenatal infection and schizophrenia** – According to Alan S. Brown of Columbia University, " | + | * **Prenatal infection and schizophrenia** – According to Alan S. Brown of Columbia University, " |
+ | * see also (({{pmid> | ||
- | * **Increased suceptibility to other probable infectious diseases** - There is an increased prevalence of Sjogren' | + | * **Increased suceptibility to other probable infectious diseases** - There is an increased prevalence of Sjogren' |
==== More evidence ==== | ==== More evidence ==== | ||
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- | * [[http:// | + | * [[https:// |
- | * [[http:// | + | * [[https:// |
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+ | Lithium and antidepressants: | ||
===== Schizophrenia tied to a range of autoimmune ills ===== | ===== Schizophrenia tied to a range of autoimmune ills ===== | ||
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===== Recent research ===== | ===== Recent research ===== | ||
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+ | </ | ||
- | The short chain fatty acids (SCFA) acetate, butyrate, and propionate, major metabolites derived from fermentation of dietary fibers by gut microbes, interact with multiple immune and metabolic pathways. The specific pathways that SCFA are thought to target, are dysregulated in cardiovascular disease, type II diabetes, and systemic inflammation. Most notably, these disorders are consistently linked to an attenuated lifespan in schizophrenia. | + | The short chain fatty acids (SCFA) acetate, butyrate, and propionate, major metabolites derived from fermentation of dietary fibers by gut microbes, interact with multiple immune and metabolic pathways. The specific pathways that SCFA are thought to target, are dysregulated in cardiovascular disease, type II diabetes, and systemic inflammation. Most notably, these disorders are consistently linked to an attenuated lifespan in schizophrenia. |
< | < | ||
- | The short chain fatty acids (SCFA) acetate, butyrate, and propionate, major metabolites derived from fermentation of dietary fibers by gut microbes, interact with multiple immune and metabolic pathways. The specific pathways that SCFA are thought to target, are dysregulated in cardiovascular disease, type II diabetes, and systemic inflammation. Most notably, these disorders are consistently linked to an attenuated lifespan in schizophrenia. | + | Although, the abovementioned studies demonstrate that SCFA are present in the brain and modify inflammation in a beneficial manner, administration of valproic acid, a medication commonly prescribed for symptoms associated with bipolar disorder and epilepsy, inhibits the transport of SCFA across the blood brain barrier in rodents (Adkison and Shen, 1996). In addition, in vitro studies reveal that free fatty acids in the intestine can have cytotoxic properties (Penn and Schmid-Schonbein, |
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- | Although, the abovementioned studies demonstrate that SCFA are present in the brain and modify inflammation in a beneficial manner, administration of valproic acid, a medication commonly prescribed for symptoms associated with bipolar disorder and epilepsy, inhibits the transport of SCFA across the blood brain barrier in rodents (Adkison and Shen, 1996). In addition, in vitro studies reveal that free fatty acids in the intestine can have cytotoxic properties (Penn and Schmid-Schonbein, | + | |
+ | [[https:// | ||
===== Impact of cannabis use ===== | ===== Impact of cannabis use ===== | ||
- | Clinical epidemiological studies have indicated cannabis use to confer a 2-fold increase in risk for subsequent onset of psychosis, with adolescent-onset use conveying even higher risk(({{pubmed> | + | Clinical epidemiological studies have indicated cannabis use to confer a 2-fold increase in risk for subsequent onset of psychosis, with adolescent-onset use conveying even higher risk(({{pmid> |
[[https:// | [[https:// | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
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* legacy content | * legacy content | ||
- | * http:// | + | * https:// |
- | Discover Magazine, "The Insanity Virus" | + | Discover Magazine, "The Insanity Virus" |
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"In light of our study, which calls attention to a pregnant woman' | "In light of our study, which calls attention to a pregnant woman' | ||
- | http:// | + | https:// |
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Cold sores may contribute to schizophrenia symptoms PMID 20153952 | Cold sores may contribute to schizophrenia symptoms PMID 20153952 | ||
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- | If you listen to the seminar at Kings College London ( http:// | + | If you listen to the seminar at Kings College London ( https:// |
The key thing is that top scientists are indeed thinking about inflammation behind psychiatric and neurological disease, and we must try and guide those thought processes so that they start looking for the correct cause of the inflammation | The key thing is that top scientists are indeed thinking about inflammation behind psychiatric and neurological disease, and we must try and guide those thought processes so that they start looking for the correct cause of the inflammation | ||
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21546214</ | 21546214</ | ||
- | [[http:// | + | [[https:// |
< | < | ||
- | ===== References ===== | + | ===== References =====</ |