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home:food [04.28.2020] – [Zinc] sallieqhome:food [09.14.2022] (current) – external edit 127.0.0.1
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 Some trace elements are altered with chronic kidney disease. Selenium, zinc, and manganese tend to be wasted, and there is growing evidence that selenium deficiency is associated with mortality on dialysis.  Some trace elements are altered with chronic kidney disease. Selenium, zinc, and manganese tend to be wasted, and there is growing evidence that selenium deficiency is associated with mortality on dialysis. 
  
-Other trace elements accumulate, such as chromium, cobalt, lead, molybdenum, and vanadium.(({{pubmed>long:31296778}}))+Other trace elements accumulate, such as chromium, cobalt, lead, molybdenum, and vanadium.(({{pmid>long:31296778}}))
  
 see also [[home:othertreatments:colloidal_silver|colloidal silver]] see also [[home:othertreatments:colloidal_silver|colloidal silver]]
  
  
-Three main areas of research have been identified (//in chronic heart failure//): 1) magnesium, electrolytes and CHF; 2) the transcriptional and antioxidant effects of zinc, selenium, copper; 3) iron-deficiency anemia and CHF.(({{pubmed>long:31242838}}))+Three main areas of research have been identified (//in chronic heart failure//): 1) magnesium, electrolytes and CHF; 2) the transcriptional and antioxidant effects of zinc, selenium, copper; 3) iron-deficiency anemia and CHF.(({{pmid>long:31242838}}))
  
  
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 === Zinc === === Zinc ===
  
-Zinc is an essential trace element that is crucial for growth, development, and maintenance of immune function. Its influence reaches all organs and cell types, representing an integral component of approximately 10% of the human proteome, and encompassing hundreds of key enzymes and transcription factors.  Zinc deficiency is strikingly common, affecting up to a quarter of the population in developing countries, but also affecting distinct populations in the developed world as a result of lifestyle, age, and disease-mediated factors. (({{pubmed>long:31305906}}))+Zinc is an essential trace element that is crucial for growth, development, and maintenance of immune function. Its influence reaches all organs and cell types, representing an integral component of approximately 10% of the human proteome, and encompassing hundreds of key enzymes and transcription factors.  Zinc deficiency is strikingly common, affecting up to a quarter of the population in developing countries, but also affecting distinct populations in the developed world as a result of lifestyle, age, and disease-mediated factors. (({{pmid>long:31305906}}))
  
-By modulating anti-inflammatory and antioxidant pathways, zinc supplementation is recommended for the treatment of several ailments, such as liver disease, male hypogonadism, cancers, heart disease (e.g. dyslipidemia) and central nervous system disorders; however, the topic of dietary vs. pharmacological doses of zinc remains controversial.(({{pubmed>long:31303527}}))+"angiotensin 2 receptor antagonists can result in an increased urinary excretion of zinc with subsequent systemic zinc deficiency" therefore those on Olmesartan may be excreting Zinc.
  
-Results suggest that zinc deficiency is associated with the presence of prehypertension in apparently healthy subjects.(({{pubmed>long:    31262235}}))+//see// Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions -a systematic review of zinc and antihypertensive therapy. Int J Clin Pract2013;67(8):717-25. doi: 10.1111/ijcp.12040 [published Online First: 2013/01/03 
 + 
 +By modulating anti-inflammatory and antioxidant pathways, zinc supplementation is recommended for the treatment of several ailments, such as liver disease, male hypogonadism, cancers, heart disease (e.g. dyslipidemia) and central nervous system disorders; however, the topic of dietary vs. pharmacological doses of zinc remains controversial.(({{pmid>long:31303527}})) 
 + 
 +Results suggest that zinc deficiency is associated with the presence of prehypertension in apparently healthy subjects.(({{pmid>long:    31262235}}))
  
 Zinc picolinate is easily absorbed, but this [[https://chrismasterjohnphd.com/lite-videos/2018/10/30/dont-recommend-zinc-picolinate/|nutrition web site]] warns against it's use. Zinc picolinate is easily absorbed, but this [[https://chrismasterjohnphd.com/lite-videos/2018/10/30/dont-recommend-zinc-picolinate/|nutrition web site]] warns against it's use.
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 === Ca/Mg ratio === === Ca/Mg ratio ===
  
-Ca/Mg ratio imbalance is associated with prostatic hyperplasia(({{pubmed>long:    28284204}}))+Ca/Mg ratio imbalance is associated with prostatic hyperplasia(({{pmid>long:    28284204}}))
  
- Ca:Mg rose from largely below 3.0 in 1994-5 to generally above or approaching 3.0 after 2000, coinciding with a sharp 2% rise in type 2 diabetes incidence and prevalence in the USA population and a 1994-2005 rise in colorectal cancer incidence among young white, non-Hispanic adult men and women in the USA.(({{pubmed>long:21233058}}))+ Ca:Mg rose from largely below 3.0 in 1994-5 to generally above or approaching 3.0 after 2000, coinciding with a sharp 2% rise in type 2 diabetes incidence and prevalence in the USA population and a 1994-2005 rise in colorectal cancer incidence among young white, non-Hispanic adult men and women in the USA.(({{pmid>long:21233058}}))
  
- findings suggested that increased Mg and decreased Ca and Ca/Mg in whole blood were correlated with metabolic syndrome in Chinese adults.(({{pubmed>long:27750224}}))+ findings suggested that increased Mg and decreased Ca and Ca/Mg in whole blood were correlated with metabolic syndrome in Chinese adults.(({{pmid>long:27750224}}))
  
  
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 === Iodine === === Iodine ===
  
-Iodine is necessary for thyroid function.  (({{pubmed>long:28160243}}))+Iodine is necessary for thyroid function.  (({{pmid>long:28160243}}))
  
 If your thyroid does not come good after some time on MP, get your Iodine status checked, An occasional drop of iodine may be warranted. Your doctor will advise. If your thyroid does not come good after some time on MP, get your Iodine status checked, An occasional drop of iodine may be warranted. Your doctor will advise.
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 === Selenium (trace element) === === Selenium (trace element) ===
  
-Association of Selenium (Se) deficiency, an essential trace element, has been found with human diseases.(({{pubmed>long:31223567}}))+Association of Selenium (Se) deficiency, an essential trace element, has been found with human diseases.(({{pmid>long:31223567}}))
  
-Review of recent progress in large-scale and systematic analyses of the relationship between selenium status or selenoproteins and several complex diseases, mainly including population-based cohort studies and meta-analyses, genetic association studies, and some other omics-based studies. Advances in ionomics and its application in studying the interaction between selenium and other trace elements in human health and diseases are also discussed.(({{pubmed>long:31236815}}))+Review of recent progress in large-scale and systematic analyses of the relationship between selenium status or selenoproteins and several complex diseases, mainly including population-based cohort studies and meta-analyses, genetic association studies, and some other omics-based studies. Advances in ionomics and its application in studying the interaction between selenium and other trace elements in human health and diseases are also discussed.(({{pmid>long:31236815}}))
  
  
 Expression of some genes is changed with selenium deficiency. Consequently, growth and proliferation of cells, their movement, development, death, and survival, as well as the interaction between cells, the redox regulation of intracellular signaling cascades of inflammation and apoptosis, depend on the selenium status of the body. Expression of some genes is changed with selenium deficiency. Consequently, growth and proliferation of cells, their movement, development, death, and survival, as well as the interaction between cells, the redox regulation of intracellular signaling cascades of inflammation and apoptosis, depend on the selenium status of the body.
  
-Organic selenium compounds have a high bioavailability and, depending on their concentration, can act both as selenium donors to prevent selenium deficiency and as antitumor drugs due to their toxicity and participation in the regulation of signaling pathways of apoptosis. (({{pubmed>long:    31258141}}))+Organic selenium compounds have a high bioavailability and, depending on their concentration, can act both as selenium donors to prevent selenium deficiency and as antitumor drugs due to their toxicity and participation in the regulation of signaling pathways of apoptosis. (({{pmid>long:    31258141}}))
  
    
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 === Boron (trace element) === === Boron (trace element) ===
  
- Via its effect on steroid hormones and interaction with mineral metabolism, boron may be involved in a number of clinical conditions such as arthritis.  (({{pubmed>long:8140253}}))+ Via its effect on steroid hormones and interaction with mineral metabolism, boron may be involved in a number of clinical conditions such as arthritis.  (({{pmid>long:8140253}}))
  
 Experiments with boron supplementation or deprivation show that boron is involved in calcium and bone metabolism, and its effects are more marked when other nutrients (cholecalciferol, magnesium) are deficient. Boron supplementation increases the serum concentration of 17 beta-estradiol and testosterone but boron excess has toxic effects on reproductive function. Boron may be involved in cerebral function via its effects on the transport across membranes. It affects the synthesis of the extracellular matrix and is beneficial in wound healing.   Experiments with boron supplementation or deprivation show that boron is involved in calcium and bone metabolism, and its effects are more marked when other nutrients (cholecalciferol, magnesium) are deficient. Boron supplementation increases the serum concentration of 17 beta-estradiol and testosterone but boron excess has toxic effects on reproductive function. Boron may be involved in cerebral function via its effects on the transport across membranes. It affects the synthesis of the extracellular matrix and is beneficial in wound healing.  
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 Usual dietary boron consumption in humans is 1-2 mg/day for adults.  Usual dietary boron consumption in humans is 1-2 mg/day for adults. 
  
- Boronated compounds have been shown to be potent anti-osteoporotic, anti-inflammatory, hypolipemic, anti-coagulant and anti-neoplastic agents both in vitro and in vivo in animals.(({{pubmed>long:9638606}}))+ Boronated compounds have been shown to be potent anti-osteoporotic, anti-inflammatory, hypolipemic, anti-coagulant and anti-neoplastic agents both in vitro and in vivo in animals.(({{pmid>long:9638606}}))
  
 <blockquote>In reality the average intake in developed countries is 1-2 mg of boron per day. Institutionalized patients may receive only 0.25 mg of daily boron. Chemical fertilizers inhibit the uptake of boron from the soil: an organic apple grown in good soil may have 20 mg boron, but if grown with fertilizer it may have only 1 mg of boron. Fertilizers combined with poor food choices have greatly reduced our boron intake compared to 50 or 100 years ago. <blockquote>In reality the average intake in developed countries is 1-2 mg of boron per day. Institutionalized patients may receive only 0.25 mg of daily boron. Chemical fertilizers inhibit the uptake of boron from the soil: an organic apple grown in good soil may have 20 mg boron, but if grown with fertilizer it may have only 1 mg of boron. Fertilizers combined with poor food choices have greatly reduced our boron intake compared to 50 or 100 years ago.
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 ===== Research ===== ===== Research =====
  
-Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome.  (({{pubmed>long:    30130151}})) +Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome.  (({{pmid>long:    30130151}})) 
  
-Walnut Consumption Alters the Gastrointestinal Microbiota, Microbially Derived Secondary Bile Acids, and Health Markers in Healthy Adults(({{pubmed>long:29726951}})) +Walnut Consumption Alters the Gastrointestinal Microbiota, Microbially Derived Secondary Bile Acids, and Health Markers in Healthy Adults(({{pmid>long:29726951}})) 
  
-Almond Consumption and Processing Affects the Composition of the Gastrointestinal Microbiota of Healthy Adult Men and Women  (({{pubmed>long:    9373513}})) +Almond Consumption and Processing Affects the Composition of the Gastrointestinal Microbiota of Healthy Adult Men and Women  (({{pmid>long:    9373513}})) 
  
-Broccoli consumption affects the human gastrointestinal microbiota. Functional prediction revealed that broccoli consumption increased the pathways involved in the functions of the endocrine system (P=.05), transport and catabolism (P=.04), and energy metabolism (P=.01).   (({{pubmed>long:30317146}})) +Broccoli consumption affects the human gastrointestinal microbiota. Functional prediction revealed that broccoli consumption increased the pathways involved in the functions of the endocrine system (P=.05), transport and catabolism (P=.04), and energy metabolism (P=.01).   (({{pmid>long:30317146}})) 
  
  
 Dietary fats influence risk of developing peripheral metabolic diseases and cognitive disorders such as Alzheimer?s disease (AD). Inflammation of the brain (neuroinflammation), a state associated with progressive neuronal loss, is known to be heightened in cognitive decline and obesity.   Dietary fats influence risk of developing peripheral metabolic diseases and cognitive disorders such as Alzheimer?s disease (AD). Inflammation of the brain (neuroinflammation), a state associated with progressive neuronal loss, is known to be heightened in cognitive decline and obesity.  
-[[http://grantome.com/grant/NIH/I01-BX004146-01A1|Obesity and associated comorbidities such as metabolic syndrome and diabetes affect up to 48% of Veterans]].  We hypothesize that dietary fats alter microglial metabolism to directly trigger dysregulated brain immune responses. +[[https://grantome.com/grant/NIH/I01-BX004146-01A1|Obesity and associated comorbidities such as metabolic syndrome and diabetes affect up to 48% of Veterans]].  We hypothesize that dietary fats alter microglial metabolism to directly trigger dysregulated brain immune responses. 
  
 Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia has specified that immune cells in the brain consume the synapses between brain neurons, when exposed to a high-fat diet. Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia has specified that immune cells in the brain consume the synapses between brain neurons, when exposed to a high-fat diet.
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 ===== Other ===== ===== Other =====
  
-[[http://nautil.us/issue/30/identity/how-the-western-diet-has-derailed-our-evolution|how-the-western-diet-has-derailed-our-evolution]]+[[https://nautil.us/issue/30/identity/how-the-western-diet-has-derailed-our-evolution|how-the-western-diet-has-derailed-our-evolution]]
  
   * **food avoidance diets** – Some patients have reported sensitivities to certain foods. Avoiding foods containing, for example, lactose or gluten may offer a decrease in symptom severity. Patients who feel this may be relevant to them should consult with a nutritionist.   * **food avoidance diets** – Some patients have reported sensitivities to certain foods. Avoiding foods containing, for example, lactose or gluten may offer a decrease in symptom severity. Patients who feel this may be relevant to them should consult with a nutritionist.
-  * **salt avoidance** – not recommended given that the body seems to naturally regulate sodium levels independently. Salt is also critical for kidney health. Sodium is used by the kidneys to excrete potassium. (({{pubmed>long:19833911}})) (({{pubmed>long:22071811}})) (for more see the //Times// article [[http://www.nytimes.com/2012/06/03/opinion/sunday/we-only-think-we-know-the-truth-about-salt.html|Salt, we misjudged you]]+  * **salt avoidance** – not recommended given that the body seems to naturally regulate sodium levels independently. Salt is also critical for kidney health. Sodium is used by the kidneys to excrete potassium. (({{pmid>long:19833911}})) (({{pmid>long:22071811}})) (for more see the //Times// article [[https://www.nytimes.com/2012/06/03/opinion/sunday/we-only-think-we-know-the-truth-about-salt.html|Salt, we misjudged you]]
   * **fasting** – Fasting is not part of the MP. It is unknown whether it provides harm or benefit to a person on the treatment.   * **fasting** – Fasting is not part of the MP. It is unknown whether it provides harm or benefit to a person on the treatment.
  
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 2018 [[https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30313-9|Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota]]  2018 [[https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30313-9|Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota]] 
-(({{pubmed>long:    29874567}}))+(({{pmid>long:    29874567}}))
  
-2019 [[https://newatlas.com/gut-bacteria-microbiome-virus-infection-immune-brain-degeneration/60623/|Gut bacteria found to help protect brain and central nervous system from harmful viruses]] (({{pubmed>long:    31309928}}))+2019 [[https://newatlas.com/gut-bacteria-microbiome-virus-infection-immune-brain-degeneration/60623/|Gut bacteria found to help protect brain and central nervous system from harmful viruses]] (({{pmid>long:    31309928}}))
  
-2012 The migrating motor complex: control mechanisms and its role in health and disease. (({{pubmed>long:    22450306}}))+2012 The migrating motor complex: control mechanisms and its role in health and disease. (({{pmid>long:    22450306}}))
  
-2018 Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension (({{pubmed>long:29779873}}))+2018 Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension (({{pmid>long:29779873}}))
  
  
 {{tag>Food_and_drink foods drinks summary foods_to_avoid}} {{tag>Food_and_drink foods drinks summary foods_to_avoid}}
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
-  (({{pubmed>long:000}})) +  (({{pmid>long:000}})) 
  
 Gillyb's update TEXT without LINKS  Gillyb's update TEXT without LINKS 
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   * Legacy content   * Legacy content
-    * http://www.marshallprotocol.com/view_topic.php?id=842&forum_id=2&jump_to=94231#p94231 e179+    * https://www.marshallprotocol.com/view_topic.php?id=842&forum_id=2&jump_to=94231#p94231 e179
     *      * 
-=====References=====+=====References=====</nodisp> 
home/food.1588114837.txt.gz · Last modified: 04.28.2020 by sallieq
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