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home:mp:managing_immunopathology [12.15.2018] – [Pain control] sallieqhome:mp:managing_immunopathology [12.15.2018] – [Strategy #7: Re-examine sources of emf in your surroundings.] sallieq
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 [[http://www.sciencedirect.com/science/article/pii/S0891061815000599|Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression.]] [[http://www.sciencedirect.com/science/article/pii/S0891061815000599|Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression.]]
  
 +==== Strategy #8: examine Magnesium status ====
 +
 +Deficiency signs and symptoms:
 +
 +General Anxiety, lethargy, weakness, agitation, depression, dysmenorrhea, hyperactivity, headache, irritability, dysacusis, low stress tolerance, loss of appetite, nausea, sleep disorders, impaired athletic performance.
 +
 +Muscle spasm, cramps in the soles of the feet, leg cramps, facial muscles, masticatory muscles, and calves, carpopedal spasm, back aches, neck pain, urinary spasms, magnesium deficiency tetany.
 +
 +Nervousness, increased sensitivity of NMDA receptors to excitatory neurotransmitters, migraine, depression, nystagmus, paraesthesia, poor memory, seizures, tremor, vertigo.
 +
 +Constipation.
 +
 +Risk of arrhythmias, supraventricular or ventricular arrhythmias, hypertension, coronary spasm, decreased myocardial pump function, digitalis sensitivity, torsade de pointes, death from heart disease.
 +
 +Hypokalaemia, hypocalcaemia, retention of sodium.
 +
 +Dyslipoproteinemia (increased blood triglycerides and cholesterol), decreased glucose tolerance, insulin resistance, increased risk of metabolic syndrome, disturbances of bone and vitamin D metabolism, resistance to PTH, low circulating levels of PTH, resistance to vitamin D, low circulating levels of 25(OH)D, recurrence of calcium oxalate calculi.
 +
 +Asthma, chronic fatigue syndrome, osteoporosis, hypertension, altered glucose homeostasis. Pregnancy Pregnancy complications (e.g., miscarriage, premature labor, eclampsia).
 +
 +:?: Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. (({{pubmed>long:15724867}}))
 +
 +These data shows that low serum magnesium levels and elevated TNF-alpha are related in the obese subjects.
 +
 +:?: Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism (({{pubmed>long:22611240}}))
 +Following in vivo MgSO4[magnesium sulfate] treatment, we observed a reduced frequency of monocytes producing TNF-α and IL-6 in women receiving MgSO4[magnesium sulfate] for clinical indications.
 +
 +:?: The potential influence of magnesium (Mg) on inflammatory responses was assessed using an ex vivo model--human whole blood incubated with and without lipopolysaccharide (LPS). Addition of LPS leads to higher levels of cytokines including TNF-alpha and IL-6. No significant effect of Mg was observed following LPS stimulation whereas high concentration of Mg inhibited the baseline level (without LPS) of TNF-alpha and IL-6 production. (({{pubmed>long:19658279}}))
 +
 +This observation contrasts with that of a previous one on Mg-deficient animals. Therefore, the weak efficiency of increasing Mg concentration in this study on the whole blood from healthy volunteers suggests that the efficiency of Mg supplementation on cytokine production induced by endotoxin challenge depends on Mg status.
 +
 +
 +:?: During the progression of Mg deficiency in a rodent model, we have observed dramatic increases in serum levels of inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] after 3 wk on a Mg-deficient diet. (({{pubmed>long:1384353}}))
 +
 +:?: Bacteria use their own pumps to collect magnesium  (({{pubmed>long:99999999}}))
 +https://phys.org/news/2016-04-bacteria-magnesium.html
 +Magnesium is a mineral found in all living organisms. Your body contains 20–30 grams of this element, most of which is in the skeleton. We humans are supplied with magnesium through our daily diet or as a supplement.
 +
 +Magnesium deficiency is not especially common, but occurs in patients with intestinal diseases such as Crohn's disease. These patients often have to live with cramps and various rheumatic illnesses. Other symptoms typical of magnesium deficiency are muscular spasms, cramp, anxiety or abnormal heart rhythms.
 +...
 +:?: Researchers at NCMM, the Centre for Molecular Medicine Norway at UiO and Oslo University Hospital have shown exactly how sensitive the bacteria's transport system is. (({{pubmed>long:99999999}}))
 +
 +Researcher Jens Preben Morth says, "We have identified a nano-sized magnesium pump."
 +
 +The researchers manipulated an E. coli bacterium so that it overproduced using its own magnesium pump.
 +
 +"The pump was isolated in the bacterium's cell membrane."
 +
 +Magnesium deficiency can be deadly for bacteria. This has led to our own cells developing a mechanism that removes magnesium and other metals from bacteria when they start to attack us.
 +
 +"In order to counteract this mechanism, the bacteria have developed a unique system to detect and attract magnesium. The bacteria manage to do this even if the amounts of magnesium in their environment are only minimal," says Morth.
 +
 +Magnesium is bound to several proteins within a cell. It is used by many of the enzymes that are involved when sugar is broken down into energy. This process is known as glycolysis.
 +
 +"Magnesium also stabilises genetic material in both humans and bacteria," Morth elaborates.
 +
 +:?: Bacterial Growth at the High Concentrations of Magnesium Sulfate Found in Martian Soils
 +https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277918/ (({{pubmed>long:99999999}}))
 +
 +:?: The Influence of Magnesium on Cell Division (({{pubmed>long:99999999}}))
 +http://www.microbiologyresearch.org/docserver/fulltext/micro/3/3/mic-3-3-418.pdf?expires=1544799125&id=id&accname=guest&checksum=2347488F53B4A681841D4CCB23F529AC
 +SUMMARY: In simple chemically defined media all of 15 bacteria failed to grow in the complete absence of magnesium. The concentration of magnesium for maximum growth was dependent upon the Gram reaction of the individual species examined, the magnesium requirements of the Gram-positive organisms being some ten times greater than the requirements of the Gram-negative organisms. In contrast to the observations made in more complex media (peptone water), normal cell division occurred in chemically defined media containing suboptimal amounts of magnesium. It is suggested that magnesium is involved in the synthesis of bacterial protoplasm as well as cell division and, in simple chemically defined media, the synthetic reactions require the higher magnesium concentration.
 +
 +......
 +
 +Myth or Reality—Transdermal Magnesium? (({{pubmed>long:99999999}}))
 +https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579607/
 +
 +Deficiency signs and symptoms:
 +
 +General Anxiety, lethargy, weakness, agitation, depression, dysmenorrhea, hyperactivity, headache, irritability, dysacusis, low stress tolerance, loss of appetite, nausea, sleep disorders, impaired athletic performance.
 +
 +Muscle spasm, cramps in the soles of the feet, leg cramps, facial muscles, masticatory muscles, and calves, carpopedal spasm, back aches, neck pain, urinary spasms, magnesium deficiency tetany.
 +
 +Nervousness, increased sensitivity of NMDA receptors to excitatory neurotransmitters, migraine, depression, nystagmus, paraesthesia, poor memory, seizures, tremor, vertigo.
 +
 +Constipation.
 +
 +Risk of arrhythmias, supraventricular or ventricular arrhythmias, hypertension, coronary spasm, decreased myocardial pump function, digitalis sensitivity, torsade de pointes, death from heart disease.
 +
 +Hypokalaemia, hypocalcaemia, retention of sodium.
 +
 +Dyslipoproteinemia (increased blood triglycerides and cholesterol), decreased glucose tolerance, insulin resistance, increased risk of metabolic syndrome, disturbances of bone and vitamin D metabolism, resistance to PTH, low circulating levels of PTH, resistance to vitamin D, low circulating levels of 25(OH)D, recurrence of calcium oxalate calculi.
 +
 +Asthma, chronic fatigue syndrome, osteoporosis, hypertension, altered glucose homeostasis. Pregnancy Pregnancy complications (e.g., miscarriage, premature labor, eclampsia).
 ===== Planning for strong immunopathology ===== ===== Planning for strong immunopathology =====
  
home/mp/managing_immunopathology.txt · Last modified: 09.14.2022 by 127.0.0.1
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