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home:mp:stages:stagefive [10.22.2016] – [The over-exuberant Stage-Five immune response] sallieqhome:mp:stages:stagefive [07.24.2020] – [Antibiotics] sallieq
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 An over-exuberant Stage Five reaction can happen in latter stages of the MP, even in the absence of antibiotics, as the immune system becomes increasingly self-sustaining and uninhibited by bacterial ligands. As this happens, antimicrobial peptides begin to successfully target the more entrenched pockets of bacterial infection in lungs, organs or joints, especially those encased by fibrotic tissue, adhesions, or scarring. Surges in immunopathology can be caused by physical stress on fibrotic tissue, by physical exertion, excessive coughing, or //exposure to sunlight//.  An over-exuberant Stage Five reaction can happen in latter stages of the MP, even in the absence of antibiotics, as the immune system becomes increasingly self-sustaining and uninhibited by bacterial ligands. As this happens, antimicrobial peptides begin to successfully target the more entrenched pockets of bacterial infection in lungs, organs or joints, especially those encased by fibrotic tissue, adhesions, or scarring. Surges in immunopathology can be caused by physical stress on fibrotic tissue, by physical exertion, excessive coughing, or //exposure to sunlight//. 
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 A Stage Five reaction is often erratic and may not be easily relieved by the usual techniques.  A Stage Five reaction is often erratic and may not be easily relieved by the usual techniques. 
  
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 When a patient's symptoms surge after an extended period on the MP, the initial strategy is to When a patient's symptoms surge after an extended period on the MP, the initial strategy is to
-discontinue azithromycin if it has been taken. //N.B. the use of azithromycin is now strongly discouraged//. This will often result in a one-time exacerbation of symptoms, particularly from days 10 to 12 (and possibly even for some weeks), as the concentration of the azithromycin slowly wanes, but in the long run will lead to greater stability.+discontinue azithromycin if it has been taken. //**N.B. the use of azithromycin is now strongly discouraged**//.  
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 +This will often result in a one-time exacerbation of symptoms, particularly from days 10 to 12 (and possibly even for some weeks), as the concentration of the azithromycin slowly wanes, but in the long run will lead to greater stability.
  
 Progressively withdrawing minocycline and clindamycin, while modulating olmesartan, should keep Progressively withdrawing minocycline and clindamycin, while modulating olmesartan, should keep
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home/mp/stages/stagefive.txt · Last modified: 09.14.2022 by 127.0.0.1
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