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home:mp:stages:stagefive [10.22.2016] – [The over-exuberant Stage-Five immune response] sallieq | home:mp:stages:stagefive [09.14.2022] (current) – external edit 127.0.0.1 | ||
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An over-exuberant Stage Five reaction can happen in latter stages of the MP, even in the absence of antibiotics, | An over-exuberant Stage Five reaction can happen in latter stages of the MP, even in the absence of antibiotics, | ||
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A Stage Five reaction is often erratic and may not be easily relieved by the usual techniques. | A Stage Five reaction is often erratic and may not be easily relieved by the usual techniques. | ||
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Unless your X-rays show the degree of damage which mine did, you should be fine with a very nominal amount of exercise. Do not do anything which tires you out. Walking around the neighborhood in the late evenings is probably a good choice (depending on your neighborhood, | Unless your X-rays show the degree of damage which mine did, you should be fine with a very nominal amount of exercise. Do not do anything which tires you out. Walking around the neighborhood in the late evenings is probably a good choice (depending on your neighborhood, | ||
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When a patient' | When a patient' | ||
- | discontinue azithromycin if it has been taken. //N.B. the use of azithromycin is now strongly discouraged// | + | discontinue azithromycin if it has been taken. //**N.B. the use of azithromycin is now strongly discouraged**//. |
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+ | This will often result in a one-time exacerbation of symptoms, particularly from days 10 to 12 (and possibly even for some weeks), as the concentration of the azithromycin slowly wanes, but in the long run will lead to greater stability. | ||
Progressively withdrawing minocycline and clindamycin, | Progressively withdrawing minocycline and clindamycin, | ||
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causing too much immunopathology, | causing too much immunopathology, | ||
- | Please ask for moderator assistance on the [[http:// | + | Please ask for moderator assistance on the [[https:// |
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===== Read more ===== | ===== Read more ===== | ||
- | * [[http:// | + | * [[https:// |
+ | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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* | * | ||
- | http:// | + | https:// |
- | http:// | + | https:// |
* There' | * There' | ||
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* IMO, Stage 5 should refer to everyone who continues to herx without abx - i.e. their own immune system is functioning properly. Then there could be a warning that a few people have had this runaway reaction, while many are having a much more gentle stage 5. --- //Julia 2009/02/04 17: | * IMO, Stage 5 should refer to everyone who continues to herx without abx - i.e. their own immune system is functioning properly. Then there could be a warning that a few people have had this runaway reaction, while many are having a much more gentle stage 5. --- //Julia 2009/02/04 17: | ||
- | ===== References ===== | + | ===== References =====</ |