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home:mp:stages [10.13.2018] – [Read more] sallieqhome:mp:stages [12.14.2018] – [Stage 2: Unhealthy VDR, pathogens downregulate immune activity] sallieq
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-=====Stage 1: Healthy Vitamin D Receptor (VDR), low pathogen load =====+=====  Prior to immune dysfunction =====
  
 In a healthy human, the body can carefully regulate activity of the VDR, which it does by controlling the concentrations of two key forms of vitamin D: 25-D and 1,25-D. Both molecules are attracted to the Receptor and bind to it for hours at a time, after which they drop off. The essential difference between the key molecules is that when 1,25-D docks to the VDR, it turns the Receptor on; when 25-D docks to the VDR, it is turned off. When it becomes necessary to turn on the VDR, the body increases production of 1,25-D. Conversely, when an active VDR is no longer necessary, the body converts 1,25-D into 25-D. In healthy humans, this control mechanism works well. For example, in the event a pathogen is noticed, the body increases production of 1,25-D, which in turn increases activity of the VDR. In a healthy human, the body can carefully regulate activity of the VDR, which it does by controlling the concentrations of two key forms of vitamin D: 25-D and 1,25-D. Both molecules are attracted to the Receptor and bind to it for hours at a time, after which they drop off. The essential difference between the key molecules is that when 1,25-D docks to the VDR, it turns the Receptor on; when 25-D docks to the VDR, it is turned off. When it becomes necessary to turn on the VDR, the body increases production of 1,25-D. Conversely, when an active VDR is no longer necessary, the body converts 1,25-D into 25-D. In healthy humans, this control mechanism works well. For example, in the event a pathogen is noticed, the body increases production of 1,25-D, which in turn increases activity of the VDR.
  
  
-=====Stage 2: Unhealthy VDR, pathogens downregulate immune activity =====+===== Process of immune system dysregulation =====
  
 Multiple pathogens including bacteria such as "gliding" biofilm bacteria and //Mycobacterium tuberculosis// as well as viruses such as Epstein-Barr and HIV have discovered a way to persist and reproduce by inactivating the VDR. In the case of the gliding biofilm bacteria, some species produce a protein called Capnine which has an effect similar to 25-D, in that it has an affinity for the VDR, but does not turn it on. Multiple pathogens including bacteria such as "gliding" biofilm bacteria and //Mycobacterium tuberculosis// as well as viruses such as Epstein-Barr and HIV have discovered a way to persist and reproduce by inactivating the VDR. In the case of the gliding biofilm bacteria, some species produce a protein called Capnine which has an effect similar to 25-D, in that it has an affinity for the VDR, but does not turn it on.
home/mp/stages.txt · Last modified: 09.14.2022 by 127.0.0.1
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