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home:mp [10.16.2017] – [Stopping olmesartan] sallieqhome:mp [06.11.2018] – [Background and scientific rationale for the therapy] sallieq
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 ===== Background and scientific rationale for the therapy ===== ===== Background and scientific rationale for the therapy =====
  
-<relatedarticles> [[home:protocol#science_behind_marshall_pathogenesis|Science behind Marshall Pathogenesis]],  [[home:protocol#science_behind_marshall_protocol|Science behind Marshall Protocol]], [[home:mp:stages|Stages of illness and recovery]] </article>+<relatedarticles> 
 +  * [[home:physicians:vitamin_d_leaflet|Testing your vitamin D metabolites]] 
 +  * [[home:protocol#science_behind_marshall_pathogenesis|Science behind Marshall Pathogenesis]] 
 +  * [[home:protocol#science_behind_marshall_protocol|Science behind Marshall Protocol]] 
 +  * [[home:mp:stages|Stages of illness and recovery]] 
 +</article>
  
  
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 ARF has prepared a [[home:physicians:emergency|Notice for emergency medical personnel]] treating a Marshall Protocol patient. Important points from that document include the following: ARF has prepared a [[home:physicians:emergency|Notice for emergency medical personnel]] treating a Marshall Protocol patient. Important points from that document include the following:
   * **Do not withdraw olmesartan** – In a critical care situation, it is essential to continue oral olmesartan, even in the presence of hypotension, as abrupt withdrawal can be life-threatening. Along with routine lifesaving procedures, it is essential to continue oral olmesartan 40mg dosing every four hours, with 20mg SL p.r.n., until symptoms subside - even if an NG tube is necessary. If B/P is extremely low (mean arterial pressure <55), continue olmesartan as above and increase fluid volume with 0.9 NS or packed red cells.   * **Do not withdraw olmesartan** – In a critical care situation, it is essential to continue oral olmesartan, even in the presence of hypotension, as abrupt withdrawal can be life-threatening. Along with routine lifesaving procedures, it is essential to continue oral olmesartan 40mg dosing every four hours, with 20mg SL p.r.n., until symptoms subside - even if an NG tube is necessary. If B/P is extremely low (mean arterial pressure <55), continue olmesartan as above and increase fluid volume with 0.9 NS or packed red cells.
-  * **antibiotics** – We strongly recommend patients not be treated with MP antibiotics for an acute infection. Unless patients have reached a late stage of the treatment these antibiotics may greatly increase immunopathology as they leave a patient's system. Fluoroquinolone antibiotics may be tolerated although instances of tendon damage have been reported; the patient should be advised of the FDA black-box warnings.  Cephalosporins, Claforin, and the macrolide Biaxin are usually tolerated.+  * **antibiotics** – We strongly recommend patients not be treated with MP antibiotics for an acute infection. Unless patients have reached a late stage of the treatment these antibiotics may greatly increase immunopathology as they leave a patient's system. Cephalosporins, Claforin, and the macrolide Biaxin are usually tolerated. Fluoroquinolone antibiotics may be tolerated although instances of tendon damage have been reported; the patient should be advised of the FDA black-box warnings. 
   * **corticosteroids** – Do not give corticosteroids in any form or by any route (injected, inhaled, oral or IV) as they will lead to metabolic instability.   * **corticosteroids** – Do not give corticosteroids in any form or by any route (injected, inhaled, oral or IV) as they will lead to metabolic instability.
   * Do not give **nimesulide** (Aulin / Mesulid / Nimed).  It could cause bleeding.     * Do not give **nimesulide** (Aulin / Mesulid / Nimed).  It could cause bleeding.  
home/mp.txt · Last modified: 09.14.2022 by 127.0.0.1
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