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//**Greg Blaney, MD**// </ | //**Greg Blaney, MD**// </ | ||
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+ | ===== Read more ===== | ||
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+ | * [[http:// | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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+ | ScienceDaily (Jan. 20, 2006) — Drugs that treat depression by manipulating the neurotransmitter serotonin in the brain may also affect the user's immune system in ways that are not yet understood, say scientists from Georgetown University Medical Center and a Canadian research institute. | ||
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+ | That's because the investigators found, for the first time, that serotonin is passed between key cells in the immune system, and that the chemical is specifically used to activate an immune response. They do not know yet, however, whether these SSRI (selective serotonin reuptake inhibitors) drugs " | ||
+ | "The wider health implication is that commonly used SSRI antidepressants, | ||
+ | He said that while it may be possible that SSRI drugs may restore a healthy immune function in people who are depressed and prone to infections, it is possible that they might also bolster immunity to the point that they trigger autoimmune disease. "At this point we just don't know how these drugs might affect immunity, so we really need to clarify the normal role of serotonin in immune cell functioning," | ||
+ | The surprising finding that serotonin is rapidly passed between immune cells in a manner similar to its transmission between brain neurons was revealed in mid-October, | ||
+ | "The novelty is that we reveal a potential communication, | ||
+ | In addition to Ahern, Peta Connell, Ph.D., from the Robarts Research Institute in Canada, was also a co-lead researcher on the study. Scientists from the Robarts Research Institute also contributed to the work. | ||
+ | In the brain, serotonin transmission between neurons is associated with feelings of pleasure, mood, and appetite, and the class of antidepressants known as SSRIs keeps serotonin active within the synaptic spaces between neurons, enhancing the chemical' | ||
+ | Specifically, | ||
+ | What the Georgetown researchers found, however, is that dendritic cells -- the most powerful of the antigen-presenting cells and the ones that can find invaders that have never infected the body and " | ||
+ | "In addition to the physical contact, it surprised us to find that these immune cells also have machinery to take up serotonin and to secrete it in an excitatory manner," | ||
+ | Drugs that block serotonin reuptake " | ||
===== References ===== | ===== References ===== |