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--- home:othertreatments:antifungals [09.05.2010] – paulalbert
+++ home:othertreatments:antifungals [08.02.2017] – [Patients experiences] sallieq
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 ====== Antifungal agents ======
-<relatedarticle> [[home:patients:assessing_literature:palliative|Palliative vs. curative treatments]] </article>
+<relatedarticles> [[home:diseases:co-infections|Co-infections]], [[home:patients:assessing_literature:palliative|Palliative vs. curative treatments]] </article>
@@ Line 25: / Line 25: @@
   * itraconazole (Sporonox)
   * ketoconazole (Nizoral)
+  * nimesulide (Aulin, Mesulid, Nimed) - may promote bleeding
   * nystatin
   * terfinabine (Lamisil)
@@ Line 36: / Line 36: @@
-Ketoconazole cream, sometimes referred to as "K-cream," is a topical cream or shampoo that some patients have noticed reduces sun flare or light-driven immunopathology. Although ketoconazole cream was once recommended to MP patients, the recommendation that patients routinely use K-cream has been withdrawn. Like the other antifungals, ketoconazole cream may inhibit bacteria die-off, especially in the skin areas where it has the highest concentration.
+Ketoconazole cream, sometimes referred to as "K-cream," is a topical cream or shampoo that may reduce sun flare or light-driven immunopathology. Although ketoconazole cream was once recommended to MP patients, the recommendation that patients routinely use K-cream has been withdrawn. Like the other antifungals, ketoconazole cream may inhibit bacteria die-off, especially in the skin areas where it has the highest concentration.
-Patients for whom light sensitivity is a problem should consider zinc oxide as an alternative for preventing moderate symptoms associated with sun exposure that cannot be avoided. For some of the most severely sun sensitive, ketoconazole cream or shampoo seems to work better for preventing or reducing sun flare symptoms, but for others, zinc oxide seems to work better.
+Patients for whom light sensitivity is a problem should consider zinc oxide as an alternative for preventing moderate symptoms associated with sun exposure that cannot be avoided. For some of the most severely sun sensitive, ketoconazole cream or shampoo seems to work better for preventing or reducing sun flare symptoms, but for others, zinc oxide (not an anti-fungal) seems to work better. Both may have inhibitory effects on the immune response.
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 //**P.Bear**, MarshallProtocol.com//</blockquote>
+<blockquote>I was at the doc for my annual physical and he suggested a anti-fungal medication. I knew I was
+"playing with fire" but I was feeling very well- excercising regularly and taking a sauna at least three time per week- without any IP. Well, six weeks into the anti-fungal medication, I was awaken from a sound sleep into a deep, very physical panic attack.
+I stopped the medication immediately. That was a few days ago. I have not had any (further) panic attacks but the anxiety and depression have been significant.
+//bobi August 2017//</blockquote>
 ===== Notes and comments =====
-EDIT
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     * http://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=34393#p34393 s226
     *
-    *
+<blockquote>I did a quick pubmed seach and found two useful articles that indicate natamycin’s action may be “to disturb ergosterol-dependent protein functions” and that  “natamycin acts via a novel mode of action and blocks fungal growth by binding specifically to ergosterol” rather than acting on the fungi cell membrane.
+. Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergoste http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876427/
+. Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. http://www.jbc.org/content/283/10/6393.long
+While a search in wikapedia states under natamycin saftety that, “Natamycin lacks acute toxicity" it then goes on to state that “In humans, a dose of 500 mg/kg/day repeated over multiple days caused nausea, vomiting, and diarrhea.”
+</blockquote>
 ===== References =====

home/othertreatments/antifungals.txt · Last modified: 09.14.2022 by 127.0.0.1