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home:othertreatments:antimetabolites:methotrexate [10.26.2018] – [Discontinuing methotrexate] sallieq | home:othertreatments:antimetabolites:methotrexate [09.14.2022] (current) – external edit 127.0.0.1 | ||
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- | Methotrexate and trimethoprim are very similar drugs. The both act on [[http:// | + | Methotrexate and trimethoprim are very similar drugs. The both act on [[https:// |
Both trimethoprim and MTX have a very high affinity for the Bacterial DHFR, while Trimethoprim has a lower affinity for human DHFR than MTX. You would need a very large dose of Trimethoprim in a human being to equal the DHFR effects of a typical rheumatologic MTX dosing regime. | Both trimethoprim and MTX have a very high affinity for the Bacterial DHFR, while Trimethoprim has a lower affinity for human DHFR than MTX. You would need a very large dose of Trimethoprim in a human being to equal the DHFR effects of a typical rheumatologic MTX dosing regime. | ||
- | //Inter alia//, DHFR catalyzes THFR, an essential step in the production of [[http:// | + | //Inter alia//, DHFR catalyzes THFR, an essential step in the production of [[https:// |
MTX therefore inhibits the synthesis of DNA and proteins, and this is the action typically attributed to it in a therapeutic environment. However, purines are very active compounds and form the basis of many human metabolites. I would note that a purine-like imidazole ring is part of the olmesartan molecule. | MTX therefore inhibits the synthesis of DNA and proteins, and this is the action typically attributed to it in a therapeutic environment. However, purines are very active compounds and form the basis of many human metabolites. I would note that a purine-like imidazole ring is part of the olmesartan molecule. | ||
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It is not harmful to the body to discontinue MTX abruptly. This is in contrast to Prednisone, where abruptly stopping can cause a number of serious problems. Some doctors think there is a risk of rebound inflammation from stopping methotrexate abruptly. Taking a few weeks to wean from MTX, while probably not necessary, is the cautious approach to avoid the symptoms of rebound inflammation. | It is not harmful to the body to discontinue MTX abruptly. This is in contrast to Prednisone, where abruptly stopping can cause a number of serious problems. Some doctors think there is a risk of rebound inflammation from stopping methotrexate abruptly. Taking a few weeks to wean from MTX, while probably not necessary, is the cautious approach to avoid the symptoms of rebound inflammation. | ||
- | However, for hepatitis patients currently using methotrexate, | + | However, for hepatitis patients currently using methotrexate, |
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
+ | </ | ||
home/othertreatments/antimetabolites/methotrexate.txt · Last modified: 09.14.2022 by 127.0.0.1
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