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--- home:othertreatments:antitnf [06.05.2010] – paulalbert
+++ home:othertreatments:antitnf [08.29.2012] – [Anti-TNF drugs] paulalbert
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 Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance and is required for proper proliferation and function of natural killer cells, T cells, B cells, macrophages, and dendritic cells.(({{pubmed>long:16331857}})) Anti-TNF drugs, also known as TNF blockers, are drugs which interfere with the body's production of TNF-alpha.(({{pubmed>long: 18387510}}))
-Anti-TNF drugs are expensive, ineffective at treating chronic disease and have a number of adverse effects.
+Anti-TNF drugs are expensive, ineffective at treating chronic disease and have a number of adverse effects. Also, anti-TNF inhibitors can make a patient feel temporarily less symptomatic, because they reduce immunopathology, the bacterial die-off reaction.
-Anti-TNF drugs can make a patient feel temporarily less symptomatic, because they reduce immunopathology, the bacterial die-off reaction.
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   * **Liver problems** – [[http://www.fda.gov/medwatch/SAFETY/2004/Remicade_12-22-04_PI.pdf|According to the FDA]], patients taking Remicade can (but rarely) experience severe hepatic reactions including acute liver failure, jaundice, hepatitis and cholestasis.
   * **Skin problems** – In one prospective trial, 25% of patients on TNF-alpha-blocking therapy suffered from a dermatological condition that led them to visit a skin specialist. In a control group of patients who were not undergoing TNF-alpha blocking therapy and had less severe disease only 13% visited a dermatologist during the same period of time.(({{pubmed>long:15899052}}))
-  * **Cancer** – One recent systematic review of the adverse effects of anti-TNF therapies as they were used in rheumatoid arthritis concluded that patients taking the drugs are at 3.3 times higher risk for "malignancies."(({{pubmed>long:16705109}})) The study's authors concluded that these side effects were dose-dependent. Since then, the FDA has issued [[http://www.fda.gov/CDER/drug/early_comm/TNF_blockers.htm|an early communication]]  about an ongoing investigation of approximately 30 reports of cancer in children and young adults.
+  * **Cancer** – One recent systematic review of the adverse effects of anti-TNF therapies as they were used in rheumatoid arthritis concluded that patients taking the drugs are at 3.3 times higher risk for "malignancies."(({{pubmed>long:16705109}})) The study's authors concluded that these side effects were dose-dependent. Since then, the FDA has issued [[http://www.fda.gov/CDER/drug/early_comm/TNF_blockers.htm|an early communication]]  about an ongoing investigation of approximately 30 reports of cancer in children and young adults. More recently, a study of over 20,000 US military veterans show that nonmelanoma skin cancer risk is about one third higher for patients with rheumatoid arthritis treated with TNF inhibitors than for similar patients treated with nonbiologic disease-modifying antirheumatic drugs (DMARDs).(({{pubmed>long:21415022}}))
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 ===== Notes and comments =====
-EDIT
   * Legacy content
     * http://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=28080#p28080 s32
 ===== References =====

home/othertreatments/antitnf.txt · Last modified: 09.14.2022 by 127.0.0.1