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home:othertreatments:antitnf [01.03.2012] – external edit 127.0.0.1home:othertreatments:antitnf [08.26.2017] – [Increased risk of infection] sallieq
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 Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance and is required for proper proliferation and function of natural killer cells, T cells, B cells, macrophages, and dendritic cells.(({{pubmed>long:16331857}})) Anti-TNF drugs, also known as TNF blockers, are drugs which interfere with the body's production of TNF-alpha.(({{pubmed>long: 18387510}})) Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance and is required for proper proliferation and function of natural killer cells, T cells, B cells, macrophages, and dendritic cells.(({{pubmed>long:16331857}})) Anti-TNF drugs, also known as TNF blockers, are drugs which interfere with the body's production of TNF-alpha.(({{pubmed>long: 18387510}}))
  
-Anti-TNF drugs are expensive, ineffective at treating chronic disease and have a number of adverse effects. +Anti-TNF drugs are expensive, ineffective at treating chronic disease and have a number of adverse effects. Also, anti-TNF inhibitors can make a patient feel temporarily less symptomatic, because they reduce immunopathology, the bacterial die-off reaction.
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-Anti-TNF drugs can make a patient feel temporarily less symptomatic, because they reduce immunopathology, the bacterial die-off reaction.+
  
  
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-[[http://www.fda.gov/medwatch/SAFETY/2001/remicadeTB_deardoc.pdf|According to Centocor]], the company which manufactures Remicade, patients taking the drug put themselves at increased risk for opportunistic infection.+[[https://google2.fda.gov/search?q=cache:8wrRnr956OEJ:www.accessdata.fda.gov/drugsatfda_docs/label/2002/inflcen062802lb.pdf+TNF-blocking+agents&client=FDAgov&output=xml_no_dtd&proxystylesheet=FDAgov&site=FDAgov&ie=UTF-8&access=p&oe=UTF-8|According to Centocor]], the company which manufactures Remicade, patients taking the drug put themselves at increased risk for opportunistic infection.
  
 <blockquote>Serious infections, including sepsis and pneumonia, have been reported in patients receiving TNF-blocking agents. Some of these infections have been fatal. <blockquote>Serious infections, including sepsis and pneumonia, have been reported in patients receiving TNF-blocking agents. Some of these infections have been fatal.
  
-//**U.S. Food and Drug Administration**//, [[http://www.fda.gov/MedWatch/safety/2006/Oct_PIs/Remicade_PI.pdf|2006 statement]]</blockquote>+//**U.S. Food and Drug Administration**//, [[https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/inflcen111099lb.pdf|page 6 : Warnings]]</blockquote>
  
 //M. tuberculosis// is one such infection.(({{pubmed>long:19565495}})) //M. tuberculosis// is one such infection.(({{pubmed>long:19565495}}))
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 To reduce the likelihood of contracting or exacerbating tuberculosis, prospective patients are routinely tested for infection via a skin test. However, as some researchers have noted, TB skin tests on patients treated with immunosupressants, which are routinely used on rheumatoid arthritis patients, are not reliable, because they result in false negatives.(({{pubmed>long:12614731}})) To reduce the likelihood of contracting or exacerbating tuberculosis, prospective patients are routinely tested for infection via a skin test. However, as some researchers have noted, TB skin tests on patients treated with immunosupressants, which are routinely used on rheumatoid arthritis patients, are not reliable, because they result in false negatives.(({{pubmed>long:12614731}}))
  
-"Exaggerated //Borreliosis// infections" have been noted(({{pubmed>long:20184613}})) as have been fatal fungal infections. In 2008, the FDA [[http://www.fda.gov/CDER/drug/InfoSheets/HCP/TNF_blockersHCP.htm|ordered stronger warnings]] on Enbrel, Remicade, Humira and Cimzia due to increased risk of fungal infections.+"Exaggerated //Borreliosis// infections" have been noted(({{pubmed>long:20184613}})) as have been fatal fungal infections. In 2008, the FDA ordered stronger warnings on Enbrel, Remicade, Humira and Cimzia due to increased risk of fungal infections.
  
 Researchers have also observed reactivation of latent viral infections, namely hepatitis B in patients who are chronic carriers of the virus. Researchers have also observed reactivation of latent viral infections, namely hepatitis B in patients who are chronic carriers of the virus.
home/othertreatments/antitnf.txt · Last modified: 09.14.2022 by 127.0.0.1
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