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home:othertreatments:boneagents [01.08.2010] – paulalberthome:othertreatments:boneagents [09.10.2010] – Links to home:diseases:home changed to home:diseases paulalbert
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-<html><div class="mainarticle">Related article:</html> [[home:diseases:osteoporosis_osteopenia|Osteoporosis and osteopenia]] <html></div></html>+<relatedarticle> [[home:diseases|Osteoporosis and osteopenia]] </article>
  
 A variety of medications including the bisphosphonates have been touted to conserve or increase bone mass. These drugs have a number of side effects and are known or suspected to interfere with proper immune function.  A variety of medications including the bisphosphonates have been touted to conserve or increase bone mass. These drugs have a number of side effects and are known or suspected to interfere with proper immune function. 
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 ===== Bisphosphonates ===== ===== Bisphosphonates =====
  
 Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digesting of bone by osteoclasts.  Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digesting of bone by osteoclasts. 
  
-Bisphosphonates have a variety of side effects:(({{pubmed>long:19371818}}))+The bisphosphonate has a variety of side effects:(({{pubmed>long:19371818}}))
   * chronic musculoskeletal pain(({{pubmed>long:17627083}}))   * chronic musculoskeletal pain(({{pubmed>long:17627083}}))
   * atrial fibrillation – Numerous studies have shown that the frequency of atrial fibrillation increases with increasing age in both men and women. Data from the Framingham Heart Study showed a greater biennial incidence of AF with increasing age, with the odds ratio rising by a factor of 2.2 for every additional 10 years of age.(({{pubmed>long:8114238}}))    * atrial fibrillation – Numerous studies have shown that the frequency of atrial fibrillation increases with increasing age in both men and women. Data from the Framingham Heart Study showed a greater biennial incidence of AF with increasing age, with the odds ratio rising by a factor of 2.2 for every additional 10 years of age.(({{pubmed>long:8114238}})) 
   * calcium deposition in the soft tissues(({{pubmed>long: 14523647}}))   * calcium deposition in the soft tissues(({{pubmed>long: 14523647}}))
 +  * osteonecrosis of the jaw, i.e. bone death
   * reduced organ function, e.g. renal dysfunction or failure   * reduced organ function, e.g. renal dysfunction or failure
-  * osteonecrosis of the jaw, i.e. bone death 
  
 Those patients with elevated 1,25-D – which is [[home:pathogenesis:vitamind:metabolism#evidence_for_high_1_25-d_in_patients_with_chronic_disease|very common]] among those suffering from Th1 disease – seem particularly predisposed to the adverse effects of dysregulated calcium metabolism. Those patients with elevated 1,25-D – which is [[home:pathogenesis:vitamind:metabolism#evidence_for_high_1_25-d_in_patients_with_chronic_disease|very common]] among those suffering from Th1 disease – seem particularly predisposed to the adverse effects of dysregulated calcium metabolism.
  
 All these meds have some effect on the immune or endocrine system and are, therefore, to be avoided. All these meds have some effect on the immune or endocrine system and are, therefore, to be avoided.
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 ==== Types of bisphopshonates ==== ==== Types of bisphopshonates ====
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   * risedronate (Actonel)   * risedronate (Actonel)
   * tiludronate (Skelid)   * tiludronate (Skelid)
 +  * zoledronic acid (Zometa, Zomera, Aclasta and Reclast)
  
  
home/othertreatments/boneagents.txt · Last modified: 09.14.2022 by 127.0.0.1
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